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Ann Rheum Dis. 2005 Jul; 64(7): 971–980.
Published online 2005 Mar 30. doi:  10.1136/ard.2004.031641
PMCID: PMC1755583

Hypoxia inducible factor (HIF) in rheumatology: low O2! See what HIF can do!

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Selected References

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Figures and Tables

Figure 1
 Transcriptionally influenced direct targets of HIF. Gene products, which are directly activated by HIF at the transcriptional level, are shown. So far more than 60 HIF target genes have been identified by binding of HIF to hypoxia responsive ...
Figure 2
 Domain structure of HIF-1α and interacting factors. Domains: NLS, nuclear localisation signal; bHLH, basic helix-loop-helix (DNA binding and dimerisation); PAS, Per/Ahr-ARNT/Sim (dimerisation); PAC, PAS associated C-terminal domain; ...
Figure 3
 Structural alignment of human HIF-1/2/3α subunits and their isoforms. Functional domains are illustrated as boxes of various shades: bHLH, basic helix-loop-helix; PAS, Per/Ahr-ARNT/Sim; PAC, PAS associated C-terminal domain; NTAD, N-terminal ...
Figure 4
 Oxygen dependent HIF regulation. HIFα targeting for proteasomal degradation under normoxic conditions (left side); hypoxic stabilisation of HIFα and recruitment of transcriptional coactivators (right side). FIH, factor inhibiting ...
Figure 5
 Factors inducing HIF transactivation activity. Cytokines: interleukin 1ß (IL1ß), tumour necrosis factor α (TNFα); hormones: insulin, thyroid hormone, follicle stimulating hormone (FSH), angiotensin II, and thrombin; ...
Figure 6
 Hormone, cytokine, and growth factor mediated signalling to regulate HIF-1α protein expression and transcriptional transactivation activity. Hormones like insulin, cytokines like tumour necrosis factor (TNFα) and interleukin ...

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