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Logo of annrheumdAnnals of the Rheumatic DiseasesCurrent TOCInstructions for authors
Ann Rheum Dis. Oct 2004; 63(10): 1335–1337.
PMCID: PMC1754758

Serum cytokine levels related to multiple dimensions of fatigue in patients with primary Sjögren's syndrome


Methods: Sixty female patients with pSS filled out a questionnaire to assess multiple dimensions of fatigue. Scores were compared with values in a population based control group (n = 139). Levels of interleukin (IL)1ß, IL2, IL6, IL10, and tumour necrosis factor α were measured in serum with commercial sandwich ELISAs. The relationship between self reported dimensions of fatigue and these serum cytokine levels was determined.

Results: Patients with pSS had high scores at all dimensions of fatigue (p<0.001): general fatigue, physical fatigue, reduced activity, reduced motivation, and mental fatigue. Fatigue levels were not related to serum cytokine levels. The incidental finding that reduced motivation was higher in patients with detectable serum levels of IL10 (p = 0.04) disappeared after correction for multiple testing.

Conclusion: Fatigue is prominent in patients with pSS and involves all dimensions of fatigue. The findings do not suggest a widespread effect of circulating cytokines on multiple aspects of fatigue.

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Figures and Tables

Figure 1
 Effect sizes (mean (SEM)) at five dimensions of fatigue of the MFI. Effect sizes compare scores assessed in 60 patients with primary Sjögren's syndrome with a normal control population.

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Group


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