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Logo of annrheumdAnnals of the Rheumatic DiseasesCurrent TOCInstructions for authors
Ann Rheum Dis. Oct 2003; 62(10): 913–915.
PMCID: PMC1754337

A role for leptin in rheumatic diseases?

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Ahima RS, Flier JS. Leptin. Annu Rev Physiol. 2000;62:413–437. [PubMed]
  • Fantuzzi G, Faggioni R. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol. 2000 Oct;68(4):437–446. [PubMed]
  • Chandra RK. Cell-mediated immunity in genetically obese C57BL/6J ob/ob) mice. Am J Clin Nutr. 1980 Jan;33(1):13–16. [PubMed]
  • Fernandes G, Handwerger BS, Yunis EJ, Brown DM. Immune response in the mutant diabetic C57BL/Ks-dt+ mouse. Discrepancies between in vitro and in vivo immunological assays. J Clin Invest. 1978 Feb;61(2):243–250. [PMC free article] [PubMed]
  • Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature. 1998 Aug 27;394(6696):897–901. [PubMed]
  • Busso Nathalie, So Alexander, Chobaz-Péclat Véronique, Morard Carole, Martinez-Soria Eduardo, Talabot-Ayer Dominique, Gabay Cem. Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis. J Immunol. 2002 Jan 15;168(2):875–882. [PubMed]
  • Howard JK, Lord GM, Matarese G, Vendetti S, Ghatei MA, Ritter MA, Lechler RI, Bloom SR. Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J Clin Invest. 1999 Oct;104(8):1051–1059. [PMC free article] [PubMed]
  • Flier JS. Lowered leptin slims immune response. Nat Med. 1998 Oct;4(10):1124–1125. [PubMed]
  • Farooqi I Sadaf, Matarese Giuseppe, Lord Graham M, Keogh Julia M, Lawrence Elizabeth, Agwu Chizo, Sanna Veronica, Jebb Susan A, Perna Francesco, Fontana Silvia, et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest. 2002 Oct;110(8):1093–1103. [PMC free article] [PubMed]
  • Matarese G, Di Giacomo A, Sanna V, Lord GM, Howard JK, Di Tuoro A, Bloom SR, Lechler RI, Zappacosta S, Fontana S. Requirement for leptin in the induction and progression of autoimmune encephalomyelitis. J Immunol. 2001 May 15;166(10):5909–5916. [PubMed]
  • Matarese Giuseppe, Sanna Veronica, Lechler Robert I, Sarvetnick Nora, Fontana Silvia, Zappacosta Serafino, La Cava Antonio. Leptin accelerates autoimmune diabetes in female NOD mice. Diabetes. 2002 May;51(5):1356–1361. [PubMed]
  • Siegmund Britta, Lehr Hans Anton, Fantuzzi Giamila. Leptin: a pivotal mediator of intestinal inflammation in mice. Gastroenterology. 2002 Jun;122(7):2011–2025. [PubMed]
  • Matarese G, Sanna V, Di Giacomo A, Lord GM, Howard JK, Bloom SR, Lechler RI, Fontana S, Zappacosta S. Leptin potentiates experimental autoimmune encephalomyelitis in SJL female mice and confers susceptibility to males. Eur J Immunol. 2001 May;31(5):1324–1332. [PubMed]
  • Sarraf P, Frederich RC, Turner EM, Ma G, Jaskowiak NT, Rivet DJ, 3rd, Flier JS, Lowell BB, Fraker DL, Alexander HR. Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. J Exp Med. 1997 Jan 6;185(1):171–175. [PMC free article] [PubMed]
  • Faggioni R, Fantuzzi G, Fuller J, Dinarello CA, Feingold KR, Grunfeld C. IL-1 beta mediates leptin induction during inflammation. Am J Physiol. 1998 Jan;274(1 Pt 2):R204–R208. [PubMed]
  • Zarkesh-Esfahani H, Pockley G, Metcalfe RA, Bidlingmaier M, Wu Z, Ajami A, Weetman AP, Strasburger CJ, Ross RJ. High-dose leptin activates human leukocytes via receptor expression on monocytes. J Immunol. 2001 Oct 15;167(8):4593–4599. [PubMed]
  • Loffreda S, Yang SQ, Lin HZ, Karp CL, Brengman ML, Wang DJ, Klein AS, Bulkley GB, Bao C, Noble PW, et al. Leptin regulates proinflammatory immune responses. FASEB J. 1998 Jan;12(1):57–65. [PubMed]
  • Faggioni R, Fantuzzi G, Gabay C, Moser A, Dinarello CA, Feingold KR, Grunfeld C. Leptin deficiency enhances sensitivity to endotoxin-induced lethality. Am J Physiol. 1999 Jan;276(1 Pt 2):R136–R142. [PubMed]
  • Gabay C, Dreyer M, Pellegrinelli N, Chicheportiche R, Meier CA. Leptin directly induces the secretion of interleukin 1 receptor antagonist in human monocytes. J Clin Endocrinol Metab. 2001 Feb;86(2):783–791. [PubMed]
  • Lee FY, Li Y, Yang EK, Yang SQ, Lin HZ, Trush MA, Dannenberg AJ, Diehl AM. Phenotypic abnormalities in macrophages from leptin-deficient, obese mice. Am J Physiol. 1999 Feb;276(2 Pt 1):C386–C394. [PubMed]
  • Mancuso Peter, Gottschalk Andrew, Phare Susan M, Peters-Golden Marc, Lukacs Nicholas W, Huffnagle Gary B. Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia. J Immunol. 2002 Apr 15;168(8):4018–4024. [PubMed]
  • Takahashi N, Waelput W, Guisez Y. Leptin is an endogenous protective protein against the toxicity exerted by tumor necrosis factor. J Exp Med. 1999 Jan 4;189(1):207–212. [PMC free article] [PubMed]
  • Hultgren OH, Tarkowski A. Leptin in septic arthritis: decreased levels during infection and amelioration of disease activity upon its administration. Arthritis Res. 2001;3(6):389–394. [PMC free article] [PubMed]
  • Fraser DA, Thoen J, Reseland JE, Førre O, Kjeldsen-Kragh J. Decreased CD4+ lymphocyte activation and increased interleukin-4 production in peripheral blood of rheumatoid arthritis patients after acute starvation. Clin Rheumatol. 1999;18(5):394–401. [PubMed]
  • Fraser DA, Thoen J, Bondhus S, Haugen M, Reseland JE, Djøseland O, Førre O, Kjeldsen-Kragh J. Reduction in serum leptin and IGF-1 but preserved T-lymphocyte numbers and activation after a ketogenic diet in rheumatoid arthritis patients. Clin Exp Rheumatol. 2000 Mar-Apr;18(2):209–214. [PubMed]
  • Bokarewa M, Bokarew D, Hultgren O, Tarkowski A. Leptin consumption in the inflamed joints of patients with rheumatoid arthritis. Ann Rheum Dis. 2003 Oct;62(10):952–956. [PMC free article] [PubMed]
  • Anders HJ, Rihl M, Heufelder A, Loch O, Schattenkirchner M. Leptin serum levels are not correlated with disease activity in patients with rheumatoid arthritis. Metabolism. 1999 Jun;48(6):745–748. [PubMed]
  • Nishiya Koji, Nishiyama Mitsuru, Chang Angela, Shinto Atsushi, Hashimoto Kozo. [Serum leptin levels in patients with rheumatoid arthritis are correlated with body mass index]. Rinsho Byori. 2002 May;50(5):524–527. [PubMed]
  • Garcia-Gonzalez Araceli, Gonzalez-Lopez Laura, Valera-Gonzalez Isela C, Cardona-Muñoz Ernesto G, Salazar-Paramo Mario, González-Ortiz Manuel, Martínez-Abundis Esperanza, Gamez-Nava Jorge I. Serum leptin levels in women with systemic lupus erythematosus. Rheumatol Int. 2002 Aug;22(4):138–141. [PubMed]
  • Evereklioglu C, Inalöz HS, Kirtak N, Doganay S, Bülbül M, Ozerol E, Er H, Ozbek E. Serum leptin concentration is increased in patients with Behçet's syndrome and is correlated with disease activity. Br J Dermatol. 2002 Aug;147(2):331–336. [PubMed]

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