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Ann Rheum Dis. Aug 2001; 60(8): 729–735.
PMCID: PMC1753808

Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis

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Figures and Tables

Figure 1
Adenosine increase by MTX and subsequent immunosuppression through adenosine receptors. (A) MTX inhibits both, conversion of GAR → FGAR and AICAR → FAICAR. However, inhibition of the second step is stronger, which results ...
Figure 2
Anti-inflammatory effects exerted by low dose MTX at the level of the synovial tissue in RA. (A) MTX reduces monocytic cell growth and increases their apoptosis. (B) MTX decreases the IL1 and IL6 secretion and increases IL1ra production. At the same ...

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