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Logo of annrheumdAnnals of the Rheumatic DiseasesCurrent TOCInstructions for authors
Ann Rheum Dis. Aug 2000; 59(8): 631–635.
PMCID: PMC1753204

Coffee consumption, rheumatoid factor, and the risk of rheumatoid arthritis


BACKGROUND—Recent epidemiological studies have suggested that smoking is a risk factor for rheumatoid factor (RF) positive rheumatoid arthritis (RA). Being overweight, high serum cholesterol, and dietary factors have in some studies been found to be associated with the risk of RA. No attention, however, has been paid to coffee consumption as a risk determinant, though it is a shared covariate of the alleged risk factors.
OBJECTIVES—This study aimed at examining coffee consumption for its associations with RF positivity and with the risk of RA.
METHODS—Coffee consumption was studied, firstly, for its association with RF (sensitised sheep cell agglutination titre [gt-or-equal, slanted]128) in a cross sectional survey of 6809 subjects with no clinical arthritis, and secondly, for its prediction of RA in a cohort of 18 981 men and women who had neither arthritis nor a history of it at the baseline examination in 1973-76. Up to late 1989, 126 subjects of the cohort study had developed RA, of whom, 89 were positive for RF by the time of diagnosis.
RESULTS—In the cross sectional survey the number of cups of coffee drunk daily was directly proportional to the prevalence of RF positivity. Adjusted for age and sex this association was significant (p value for linear trend, 0.008), but after further adjustment for smoking the linear trend declined below significance (p=0.06). In the cohort study there was an association between coffee consumption and the risk of RF positive RA that was not due to age, sex, level of education, smoking, alcohol intake, body mass index, or serum cholesterol. After adjustment for these potential confounders the users of four or more cups a day still had a relative risk of 2.20 (95% confidence interval 1.13 to 4.27) for developing RF positive RA compared with those drinking less. Coffee consumption did not predict the development of RF negative RA.
CONCLUSION—Coffee consumption may be a risk factor for RA, possibly through mechanisms contributing to the production of RF. This hypothesis remains to be tested in further studies.

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Selected References

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  • Aho K, Palusuo T, Kurki P. Marker antibodies of rheumatoid arthritis: diagnostic and pathogenetic implications. Semin Arthritis Rheum. 1994 Jun;23(6):379–387. [PubMed]
  • Wolfe F. The natural history of rheumatoid arthritis. J Rheumatol Suppl. 1996 Mar;44:13–22. [PubMed]
  • Heliövaara M, Aho K, Aromaa A, Knekt P, Reunanen A. Smoking and risk of rheumatoid arthritis. J Rheumatol. 1993 Nov;20(11):1830–1835. [PubMed]
  • Deighton C. Smoke gets in your joints? Ann Rheum Dis. 1997 Aug;56(8):453–454. [PMC free article] [PubMed]
  • Symmons DP, Bankhead CR, Harrison BJ, Brennan P, Barrett EM, Scott DG, Silman AJ. Blood transfusion, smoking, and obesity as risk factors for the development of rheumatoid arthritis: results from a primary care-based incident case-control study in Norfolk, England. Arthritis Rheum. 1997 Nov;40(11):1955–1961. [PubMed]
  • Uhlig T, Hagen KB, Kvien TK. Current tobacco smoking, formal education, and the risk of rheumatoid arthritis. J Rheumatol. 1999 Jan;26(1):47–54. [PubMed]
  • Wilson K, Goldsmith CH. Does smoking cause rheumatoid arthritis? J Rheumatol. 1999 Jan;26(1):1–3. [PubMed]
  • Tuomi T, Heliövaara M, Palosuo T, Aho K. Smoking, lung function, and rheumatoid factors. Ann Rheum Dis. 1990 Oct;49(10):753–756. [PMC free article] [PubMed]
  • Jónsson T, Thorsteinsson J, Valdimarsson H. Does smoking stimulate rheumatoid factor production in non-rheumatic individuals? APMIS. 1998 Oct;106(10):970–974. [PubMed]
  • Voigt LF, Koepsell TD, Nelson JL, Dugowson CE, Daling JR. Smoking, obesity, alcohol consumption, and the risk of rheumatoid arthritis. Epidemiology. 1994 Sep;5(5):525–532. [PubMed]
  • Heliövaara M, Aho K, Knekt P, Reunanen A, Aromaa A. Serum cholesterol and risk of rheumatoid arthritis in a cohort of 52 800 men and women. Br J Rheumatol. 1996 Mar;35(3):255–257. [PubMed]
  • Heliövaara M, Knekt P, Aho K, Aaran RK, Alfthan G, Aromaa A. Serum antioxidants and risk of rheumatoid arthritis. Ann Rheum Dis. 1994 Jan;53(1):51–53. [PMC free article] [PubMed]
  • Comstock GW, Burke AE, Hoffman SC, Helzlsouer KJ, Bendich A, Masi AT, Norkus EP, Malamet RL, Gershwin ME. Serum concentrations of alpha tocopherol, beta carotene, and retinol preceding the diagnosis of rheumatoid arthritis and systemic lupus erythematosus. Ann Rheum Dis. 1997 May;56(5):323–325. [PMC free article] [PubMed]
  • Linos A, Kaklamanis E, Kontomerkos A, Koumantaki Y, Gazi S, Vaiopoulos G, Tsokos GC, Kaklamanis P. The effect of olive oil and fish consumption on rheumatoid arthritis--a case control study. Scand J Rheumatol. 1991;20(6):419–426. [PubMed]
  • Shapiro JA, Koepsell TD, Voigt LF, Dugowson CE, Kestin M, Nelson JL. Diet and rheumatoid arthritis in women: a possible protective effect of fish consumption. Epidemiology. 1996 May;7(3):256–263. [PubMed]
  • Schreiber GB, Robins M, Maffeo CE, Masters MN, Bond AP, Morganstein D. Confounders contributing to the reported associations of coffee or caffeine with disease. Prev Med. 1988 May;17(3):295–309. [PubMed]
  • Aho K, Heliövaara M, Sievers K, Maatela J, Isomäki H. Clinical arthritis associated with positive radiological and serological findings in Finnish adults. Rheumatol Int. 1989;9(1):7–11. [PubMed]
  • Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972 Jun;18(6):499–502. [PubMed]
  • Reunanen A, Aromaa A, Pyörälä K, Punsar S, Maatela J, Knekt P. The Social Insurance Institution's coronary heart disease study. Baseline data and 5-year mortality experience. Acta Med Scand Suppl. 1983;673:1–120. [PubMed]
  • Hakala M, Pöllänen R, Nieminen P. The ARA 1987 revised criteria select patients with clinical rheumatoid arthritis from a population based cohort of subjects with chronic rheumatic diseases registered for drug reimbursement. J Rheumatol. 1993 Oct;20(10):1674–1678. [PubMed]
  • Hughes JR, Oliveto AH. A systematic survey of caffeine intake in Vermont. Exp Clin Psychopharmacol. 1997 Nov;5(4):393–398. [PubMed]
  • Kaipiainen-Seppänen O, Aho K, Isomäki H, Laakso M. Shift in the incidence of rheumatoid arthritis toward elderly patients in Finland during 1975-1990. Clin Exp Rheumatol. 1996 Sep-Oct;14(5):537–542. [PubMed]
  • Heckers H, Göbel U, Kleppel U. End of the coffee mystery: diterpene alcohols raise serum low-density lipoprotein cholesterol and triglyceride levels. J Intern Med. 1994 Feb;235(2):192–193. [PubMed]

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