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Logo of annrheumdAnnals of the Rheumatic DiseasesCurrent TOCInstructions for authors
Ann Rheum Dis. Oct 1997; 56(10): 596–600.
PMCID: PMC1752273

Pulmonary function tests and high resolution computed tomography of the lungs in patients with rheumatoid arthritis

Abstract

OBJECTIVE—To compare the results of pulmonary function tests (PFTs) and high resolution computed tomography (HRCT) of the lungs in rheumatoid arthritis (RA) patients.
METHODS—Sixty eight patients (54 women, 14 men) fulfilling the revised criteria for RA were consecutively included in a transversal prospective study. Their mean age was 58.8 years (range: 35-82) and the mean duration of the disease was 12 years (range: 5-16). Rheumatoid factor was positive in 52 patients (76.5%). Fifty two patients (76.5%) were lifelong non-smokers. Detailed medical and drug histories were obtained. PFTs comprised spirometry and gas transfer measurements. Results for PFTs were expressed as percentage of predicted values for each individual adjusted for age, sex, and height. HRCT was undertaken with a Siemens Somatom Plus.
RESULTS—A significant decrease of FEV1/FVC, FEF25%, FEF50%, FEF75%, FEF25-75%, and TLCO was observed (p<0.05) and 13.2% of the patients had a small airways involvement defined by a decrease of FEF25-75% below 1.64 SD. The most frequent HRCT findings were: bronchiectasis (30.5%), pulmonary nodules (28%), and air trapping (25%). The patients with small airways involvement had a high frequency of recurrent bronchitis (75% v 34%, p=0.05) and bronchiectasis (71% v 23%, p=0.019). The patients with bronchiectasis were characterised by low values of FEV1, FVC, FEF25-75%, and TLCO (p<0.01), a high prevalence of small airways involvement (29% v 5%, p=0.019), and a low prevalence of HLA DQA1 *0501 allele (14% v 33%, p<0.05).
CONCLUSION—This study suggests a significant association between small airways involvement on PFTs and bronchiectasis on HRCT in unselected RA patients.

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Selected References

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  • Anaya JM, Diethelm L, Ortiz LA, Gutierrez M, Citera G, Welsh RA, Espinoza LR. Pulmonary involvement in rheumatoid arthritis. Semin Arthritis Rheum. 1995 Feb;24(4):242–254. [PubMed]
  • Geddes DM, Webley M, Emerson PA. Airways obstruction in rheumatoid arthritis. Ann Rheum Dis. 1979 Jun;38(3):222–225. [PMC free article] [PubMed]
  • Banks J, Banks C, Cheong B, Umachandran V, Smith AP, Jessop JD, Pritchard MH. An epidemiological and clinical investigation of pulmonary function and respiratory symptoms in patients with rheumatoid arthritis. Q J Med. 1992 Nov-Dec;85(307-308):795–806. [PubMed]
  • Hassan WU, Keaney NP, Holland CD, Kelly CA. Bronchial reactivity and airflow obstruction in rheumatoid arthritis. Ann Rheum Dis. 1994 Aug;53(8):511–514. [PMC free article] [PubMed]
  • Fewins HE, McGowan I, Whitehouse GH, Williams J, Mallya R. High definition computed tomography in rheumatoid arthritis associated pulmonary disease. Br J Rheumatol. 1991 Jun;30(3):214–216. [PubMed]
  • McDonagh J, Greaves M, Wright AR, Heycock C, Owen JP, Kelly C. High resolution computed tomography of the lungs in patients with rheumatoid arthritis and interstitial lung disease. Br J Rheumatol. 1994 Feb;33(2):118–122. [PubMed]
  • Hassan WU, Keaney NP, Holland CD, Kelly CA. High resolution computed tomography of the lung in lifelong non-smoking patients with rheumatoid arthritis. Ann Rheum Dis. 1995 Apr;54(4):308–310. [PMC free article] [PubMed]
  • Cortet B, Flipo RM, Rémy-Jardin M, Coquerelle P, Duquesnoy B, Rêmy J, Delcambre B. Use of high resolution computed tomography of the lungs in patients with rheumatoid arthritis. Ann Rheum Dis. 1995 Oct;54(10):815–819. [PMC free article] [PubMed]
  • Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988 Mar;31(3):315–324. [PubMed]
  • Ritchie DM, Boyle JA, McInnes JM, Jasani MK, Dalakos TG, Grieveson P, Buchanan WW. Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. Q J Med. 1968 Jul;37(147):393–406. [PubMed]
  • Guillemin F, Brainçon S, Pourel J. Mesure de la capacité fonctionnelle dans la polyarthrite rhumatoïde: adaptation française du Health Assessment Questionnaire (HAQ). Rev Rhum Mal Osteoartic. 1991 Jun;58(6):459–465. [PubMed]
  • Danzé PM, Bianchi F, Fajardy I, Rousseaux J. An improved strategy for HLA-DRB1 subtyping by digestion of PCR-amplified DNA with allele-specific restriction endonucleases. Appl Theor Electrophor. 1995;5(1):7–13. [PubMed]
  • Vitali C, Bombardieri S, Moutsopoulos HM, Balestrieri G, Bencivelli W, Bernstein RM, Bjerrum KB, Braga S, Coll J, de Vita S, et al. Preliminary criteria for the classification of Sjögren's syndrome. Results of a prospective concerted action supported by the European Community. Arthritis Rheum. 1993 Mar;36(3):340–347. [PubMed]
  • Larsen A. Radiological grading of rheumatoid arthritis. An interobserver study. Scand J Rheumatol. 1973;2(3):136–138. [PubMed]
  • Naidich DP, McCauley DI, Khouri NF, Stitik FP, Siegelman SS. Computed tomography of bronchiectasis. J Comput Assist Tomogr. 1982 Jun;6(3):437–444. [PubMed]
  • Austin JH, Müller NL, Friedman PJ, Hansell DM, Naidich DP, Remy-Jardin M, Webb WR, Zerhouni EA. Glossary of terms for CT of the lungs: recommendations of the Nomenclature Committee of the Fleischner Society. Radiology. 1996 Aug;200(2):327–331. [PubMed]
  • Bamji A, Cooke N. Rheumatoid arthritis and chronic bronchial suppuration. Scand J Rheumatol. 1985;14(1):15–21. [PubMed]
  • Radoux V, Ménard HA, Bégin R, Décary F, Koopman WJ. Airways disease in rheumatoid arthritis patients. One element of a general exocrine dysfunction. Arthritis Rheum. 1987 Mar;30(3):249–256. [PubMed]
  • Linstow M, Ulrik CS, Kriegbaum NJ, Backer V, Oxholm P. An 8-year follow-up study of pulmonary function in patients with rheumatoid arthritis. Rheumatol Int. 1994;14(3):115–118. [PubMed]
  • Demaziere A, Maugars Y, Chollet S, Prost A. Non-fatal bronchiolitis obliterans possibly associated with tiopronin. A case report with long-term follow-up. Br J Rheumatol. 1993 Feb;32(2):172–174. [PubMed]
  • Shadick NA, Fanta CH, Weinblatt ME, O'Donnell W, Coblyn JS. Bronchiectasis. A late feature of severe rheumatoid arthritis. Medicine (Baltimore) 1994 May;73(3):161–170. [PubMed]
  • Hillarby MC, McMahon MJ, Grennan DM, Cooper RG, Clarkson RW, Davies EJ, Sanders PA, Chattopadhyay C, Swinson D. HLA associations in subjects with rheumatoid arthritis and bronchiectasis but not with other pulmonary complications of rheumatoid disease. Br J Rheumatol. 1993 Sep;32(9):794–797. [PubMed]

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