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Infect Immun. Jul 1996; 64(7): 2824–2828.
PMCID: PMC174148

Structural and immunological characterization of Burkholderia pseudomallei O-polysaccharide-flagellin protein conjugates.


The O-polysaccharide moiety of Burkholderia pseudomallei 319a lipopolysaccharide was covalently linked to flagellin protein isolated from the same strain. A glycoconjugate incorporating adipic acid dihydrazide as a spacer molecule elicited high-titer immunoglobulin G responses to both the protein and carbohydrate components of the construct. This immunoglobulin G was capable of protecting diabetic rats from challenge with a heterologous B. pseudomallei strain.

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Selected References

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