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Logo of jnnpsycJournal of Neurology, Neurosurgery and PsychiatryCurrent TOCInstructions for authors
J Neurol Neurosurg Psychiatry. Feb 2004; 75(2): 226–230.
PMCID: PMC1738920

Correlation of anxiety and depression symptoms in patients with restless legs syndrome: a population based survey

Abstract

Background and objectives: Restless legs syndrome (RLS) is an important and common cause of insomnia, and previous studies indicate that psychiatric wellbeing may be impaired among RLS patients. We aimed to investigate the interaction between anxiety/depression and RLS in a population based survey.

Methods: Data were drawn from the Mersin University Neuro-Epidemiology Project, a representative community sample of adults aged over 17 years residing in Mersin (n = 3234). Subjects found to be positive for RLS (n = 103) were evaluated for symptoms of anxiety and depression using the Hamilton Anxiety and Depression Scales and compared with the same number of contemporaneous control subjects.

Results: Significantly greater anxiety and depression symptoms were observed among patients with RLS than in the control subjects. Our data also seem to provide initial evidence of a correlation between the severity of RLS and of anxiety and depression symptoms (r = 0.21, p = 0.03 and r = 0.201, p = 0.04 respectively).

Conclusions: Assessment of psychiatric status of RLS patients can be helpful and sometimes necessary to determine additional features and treatment strategies of this bothering condition. Further studies are needed to replicate our findings using longitudinal data.

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Selected References

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  • Walters AS. Toward a better definition of the restless legs syndrome. The International Restless Legs Syndrome Study Group. Mov Disord. 1995 Sep;10(5):634–642. [PubMed]
  • Trenkwalder C, Hening WA, Walters AS, Campbell SS, Rahman K, Chokroverty S. Circadian rhythm of periodic limb movements and sensory symptoms of restless legs syndrome. Mov Disord. 1999 Jan;14(1):102–110. [PubMed]
  • Turjanski N, Lees AJ, Brooks DJ. Striatal dopaminergic function in restless legs syndrome: 18F-dopa and 11C-raclopride PET studies. Neurology. 1999 Mar 23;52(5):932–937. [PubMed]
  • Ruottinen HM, Partinen M, Hublin C, Bergman J, Haaparanta M, Solin O, Rinne JO. An FDOPA PET study in patients with periodic limb movement disorder and restless legs syndrome. Neurology. 2000 Jan 25;54(2):502–504. [PubMed]
  • Wetter TC, Collado-Seidel V, Pollmächer T, Yassouridis A, Trenkwalder C. Sleep and periodic leg movement patterns in drug-free patients with Parkinson's disease and multiple system atrophy. Sleep. 2000 May 1;23(3):361–367. [PubMed]
  • Goodman JD, Brodie C, Ayida GA. Restless leg syndrome in pregnancy. BMJ. 1988 Oct 29;297(6656):1101–1102. [PMC free article] [PubMed]
  • McParland P, Pearce JM. Restless legs syndrome in pregnancy. Case reports. Clin Exp Obstet Gynecol. 1990;17(1):5–6. [PubMed]
  • Lavigne GJ, Montplaisir JY. Restless legs syndrome and sleep bruxism: prevalence and association among Canadians. Sleep. 1994 Dec;17(8):739–743. [PubMed]
  • Chokroverty S, Jankovic J. Restless legs syndrome: a disease in search of identity. Neurology. 1999 Mar 23;52(5):907–910. [PubMed]
  • Rothdach AJ, Trenkwalder C, Haberstock J, Keil U, Berger K. Prevalence and risk factors of RLS in an elderly population: the MEMO study. Memory and Morbidity in Augsburg Elderly. Neurology. 2000 Mar 14;54(5):1064–1068. [PubMed]
  • Bahk Won-Myong, Pae Chi-Un, Chae Jeong-Ho, Jun Tae-Youn, Kim Kwang-Soo. Mirtazapine may have the propensity for developing a restless legs syndrome? A case report. Psychiatry Clin Neurosci. 2002 Apr;56(2):209–210. [PubMed]
  • Bonin B, Vandel P, Kantelip JP. Mirtazapine and restless leg syndrome: a case report. Therapie. 2000 Sep-Oct;55(5):655–656. [PubMed]
  • Hargrave R, Beckley DJ. Restless leg syndrome exacerbated by sertraline. Psychosomatics. 1998 Mar-Apr;39(2):177–178. [PubMed]
  • Markkula J, Lauerma H. Mianserin and restless legs. Int Clin Psychopharmacol. 1997 Jan;12(1):53–58. [PubMed]
  • Sanz-Fuentenebro FJ, Huidobro A, Tejadas-Rivas A. Restless legs syndrome and paroxetine. Acta Psychiatr Scand. 1996 Dec;94(6):482–484. [PubMed]
  • Bakshi R. Fluoxetine and restless legs syndrome. J Neurol Sci. 1996 Oct;142(1-2):151–152. [PubMed]
  • Salín-Pascual RJ, Galicia-Polo L, Drucker-Colín R. Sleep changes after 4 consecutive days of venlafaxine administration in normal volunteers. J Clin Psychiatry. 1997 Aug;58(8):348–350. [PubMed]
  • GORMAN CA, DYCK PJ, PEARSON JS. SYMPTOM OF RESTLESS LEGS. Arch Intern Med. 1965 Feb;115:155–160. [PubMed]
  • Phillips B, Young T, Finn L, Asher K, Hening WA, Purvis C. Epidemiology of restless legs symptoms in adults. Arch Intern Med. 2000 Jul 24;160(14):2137–2141. [PubMed]
  • Saletu Michael, Anderer Peter, Saletu Bernd, Lindeck-Pozza Lisa, Hauer Catharina, Saletu-Zyhlarz Gerda. EEG mapping in patients with restless legs syndrome as compared with normal controls. Psychiatry Res. 2002 Aug 20;115(1-2):49–61. [PubMed]
  • Akdemir A, Türkçapar MH, Orsel SD, Demirergi N, Dag I, Ozbay MH. Reliability and validity of the Turkish version of the Hamilton Depression Rating Scale. Compr Psychiatry. 2001 Mar-Apr;42(2):161–165. [PubMed]
  • GORMAN CA, DYCK PJ, PEARSON JS. SYMPTOM OF RESTLESS LEGS. Arch Intern Med. 1965 Feb;115:155–160. [PubMed]
  • Kuny S. Psychiatrische Katamnese bei Patienten mit "restless legs". Schweiz Med Wochenschr. 1991 Jan 19;121(3):72–76. [PubMed]
  • Amering M, Bankier B, Berger P, Griengl H, Windhaber J, Katschnig H. Panic disorder and cigarette smoking behavior. Compr Psychiatry. 1999 Jan-Feb;40(1):35–38. [PubMed]
  • Sonntag H, Wittchen HU, Höfler M, Kessler RC, Stein MB. Are social fears and DSM-IV social anxiety disorder associated with smoking and nicotine dependence in adolescents and young adults? Eur Psychiatry. 2000 Feb;15(1):67–74. [PubMed]

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