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Infect Immun. 1996 March; 64(3): 1048–1050. | PMCID: PMC173879 |
Lesions of primary and secondary syphilis contain activated cytolytic T cells. W C van Voorhis, L K Barrett, J M Nasio, F A Plummer, and S A Lukehart Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, 98195, USA. This study demonstrates that CD8+ cytotoxic lymphocytes (CTL) are found in both primary and secondary syphilis lesions. CD8+ T cells were detected by immunohistology, and mRNAs for granzyme B and perforin were detected by reverse transcription and PCR, suggesting that CD8+ cytotoxic lymphocytes are activated. The Full Text of this article is available as a PDF (397K). These references are in PubMed. This may not be the complete list of references from this article. - Baker-Zander SA, Lukehart SA. Macrophage-mediated killing of opsonized Treponema pallidum. J Infect Dis. 1992 Jan;165(1):69–74. [PubMed]
- D'Andrea A, Rengaraju M, Valiante NM, Chehimi J, Kubin M, Aste M, Chan SH, Kobayashi M, Young D, Nickbarg E, et al. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J Exp Med. 1992 Nov 1;176(5):1387–1398. [PubMed]
- Engelkens HJ, ten Kate FJ, Judanarso J, Vuzevski VD, van Lier JB, Godschalk JC, van der Sluis JJ, Stolz E. The localisation of treponemes and characterisation of the inflammatory infiltrate in skin biopsies from patients with primary or secondary syphilis, or early infectious yaws. Genitourin Med. 1993 Apr;69(2):102–107. [PubMed]
- Harding CV, Song R. Phagocytic processing of exogenous particulate antigens by macrophages for presentation by class I MHC molecules. J Immunol. 1994 Dec 1;153(11):4925–4933. [PubMed]
- Jenne DE, Tschopp J. Granzymes, a family of serine proteases released from granules of cytolytic T lymphocytes upon T cell receptor stimulation. Immunol Rev. 1988 Mar;103:53–71. [PubMed]
- Kovacsovics-Bankowski M, Rock KL. A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules. Science. 1995 Jan 13;267(5195):243–246. [PubMed]
- Lipman ML, Stevens AC, Strom TB. Heightened intragraft CTL gene expression in acutely rejecting renal allografts. J Immunol. 1994 May 15;152(10):5120–5127. [PubMed]
- Liu CC, Walsh CM, Young JD. Perforin: structure and function. Immunol Today. 1995 Apr;16(4):194–201. [PubMed]
- Lukehart SA, Baker-Zander SA, Lloyd RM, Sell S. Characterization of lymphocyte responsiveness in early experimental syphilis. II. Nature of cellular infiltration and Treponema pallidum distribution in testicular lesions. J Immunol. 1980 Jan;124(1):461–467. [PubMed]
- Lukehart SA, Baker-Zander SA, Lloyd RM, Sell S. Effect of cortisone administration on host-parasite relationships in early experimental syphilis. J Immunol. 1981 Oct;127(4):1361–1368. [PubMed]
- Sykes JA, Miller JN. Intracellular location of Treponema pallidum (Nichols strain) in the rabbit testis. Infect Immun. 1971 Sep;4(3):307–314. [PubMed]
- Tosca A, Lehou J, Hatjivasiliou M, Varelzidis A, Stratigos JD. Infiltrate of syphilitic lesions before and after treatment. Genitourin Med. 1988 Oct;64(5):289–293. [PubMed]
- Van Voorhis WC, Barrett LK, Koelle DM, Nasio JM, Plummer FA, Lukehart SA. Primary and secondary syphilis lesions contain mRNA for Th1 cytokines. J Infect Dis. 1996 Feb;173(2):491–495. [PubMed]
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