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Infect Immun. Sep 1995; 63(9): 3718–3721.
PMCID: PMC173517

Construction and characterization of an isogenic urease-negative mutant of Helicobacter mustelae.


Helicobacter mustelae infects the ferret stomach and provides an opportunity to study pathogenic determinants of a Helicobacter species in its natural host. We constructed an isogenic urease-negative mutant of H. mustelae which produced no detectable urease and showed a reduced acid tolerance. This mutant provides an opportunity to further evaluate the role of urease in the pathogenesis of Helicobacter infection.

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Selected References

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