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Logo of jepicomhInstructions for authorsCurrent TOCJournal of Epidemiology and Community Health
J Epidemiol Community Health. Sep 2004; 58(9): 758–765.
PMCID: PMC1732890

Capture-recapture estimates of problem drug use and the use of simulation based confidence intervals in a stratified analysis

Abstract

Study objective: To establish the prevalence of problem drug use in the 10 local authorities within the Metropolitan County of Greater Manchester between April 2000 and March 2001.

Setting and participants: Problem drug users aged 16–54 resident within Greater Manchester who attended community based statutory drug treatment agencies, were in contact with general practitioners, were assessed by arrest referral workers, were in contact with the probation service, or arrested under the Misuse of Drugs Act for offences involving possession of opioids, cocaine, or benzodiazepines.

Design: Multi-sample stratified capture-recapture analysis. Patterns of overlaps between data sources were modelled in a log-linear regression to estimate the hidden number of drug users within each of 60 area, age group, and gender strata. Simulation methods were used to generate 95% confidence intervals for the sums of the stratified estimates.

Main results: The total number of problem drug users in Greater Manchester was estimated to be 19 255 giving a prevalence of problem drug use of 13.7 (95% CI 13.4 to 15.7) per 1000 population aged 16–54. The ratio of men to women was 3.5:1. The distribution of problem drug users varied across three age groups (16–24, 25–34, and 35–54) and varied between the 10 areas.

Conclusions: Areas in close geographical proximity display different patterns of drug use in terms of prevalence rates and age and gender patterns. This has important implications, both for future planning of service provision and for the way in which the impact of drug misuse interventions are evaluated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Wittes J, Sidel VW. A generalization of the simple capture-recapture model with applications to epidemiological research. J Chronic Dis. 1968 Aug;21(5):287–301. [PubMed]
  • Hook EB, Regal RR. Capture-recapture methods in epidemiology: methods and limitations. Epidemiol Rev. 1995;17(2):243–264. [PubMed]
  • Hook EB, Regal RR. Internal validity analysis: a method for adjusting capture-recapture estimates of prevalence. Am J Epidemiol. 1995 Nov 1;142(9 Suppl):S48–S52. [PubMed]
  • Beynon C, Bellis MA, Millar T, Meier P, Thomson R, Mackway Jones K. Hidden need for drug treatment services: measuring levels of problematic drug use in the North West of England. J Public Health Med. 2001 Dec;23(4):286–291. [PubMed]
  • Hickman M, Cox S, Harvey J, Howes S, Farrell M, Frischer M, Stimson G, Taylor C, Tilling K. Estimating the prevalence of problem drug use in inner London: a discussion of three capture-recapture studies. Addiction. 1999 Nov;94(11):1653–1662. [PubMed]
  • Squires NF, Beeching NJ, Schlecht BJ, Ruben SM. An estimate of the prevalence of drug misuse in Liverpool and a spatial analysis of known addiction. J Public Health Med. 1995 Mar;17(1):103–109. [PubMed]
  • Frischer M, Leyland A, Cormack R, Goldberg DJ, Bloor M, Green ST, Taylor A, Covell R, McKeganey N, Platt S. Estimating the population prevalence of injection drug use and infection with human immunodeficiency virus among injection drug users in Glasgow, Scotland. Am J Epidemiol. 1993 Aug 1;138(3):170–181. [PubMed]
  • Hay G, McKeganey N. Estimating the prevalence of drug misuse in Dundee, Scotland: an application of capture-recapture methods. J Epidemiol Community Health. 1996 Aug;50(4):469–472. [PMC free article] [PubMed]
  • Hay G. Capture-recapture estimates of drug misuse in urban and non-urban settings in the north east of Scotland. Addiction. 2000 Dec;95(12):1795–1803. [PubMed]
  • Buster MC, van Brussel GH, van den Brink W. Estimating the number of opiate users in amsterdam by capture-recapture: the importance of case definition. Eur J Epidemiol. 2001;17(10):935–942. [PubMed]
  • Domingo-Salvany A, Hartnoll RL, Maguire A, Suelves JM, Antó JM. Use of capture-recapture to estimate the prevalence of opiate addiction in Barcelona, Spain, 1989. Am J Epidemiol. 1995 Mar 15;141(6):567–574. [PubMed]
  • Hser YI. Population estimates of intravenous drug users and HIV infection in Los Angeles County. Int J Addict. 1993 Jun;28(8):695–709. [PubMed]
  • Mastro TD, Kitayaporn D, Weniger BG, Vanichseni S, Laosunthorn V, Uneklabh T, Uneklabh C, Choopanya K, Limpakarnjanarat K. Estimating the number of HIV-infected injection drug users in Bangkok: a capture--recapture method. Am J Public Health. 1994 Jul;84(7):1094–1099. [PMC free article] [PubMed]
  • Larson A, Stevens A, Wardlaw G. Indirect estimates of 'hidden' populations: capture-recapture methods to estimate the numbers of heroin users in the Australian Capital Territory. Soc Sci Med. 1994 Sep;39(6):823–831. [PubMed]
  • Cormack RM. Interval estimation for mark-recapture studies of closed populations. Biometrics. 1992 Jun;48(2):567–576. [PubMed]
  • Comiskey CM, Barry JM. A capture-recapture study of the prevalence and implications of opiate use in Dublin. Eur J Public Health. 2001 Jun;11(2):198–200. [PubMed]
  • Millar T, Craine N, Carnwath T, Donmall M. The dynamics of heroin use; implications for intervention. J Epidemiol Community Health. 2001 Dec;55(12):930–933. [PMC free article] [PubMed]

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