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J Clin Pathol. Mar 2001; 54(3): 176–186.
PMCID: PMC1731363

Antioxidants in health and disease


Free radical production occurs continuously in all cells as part of normal cellular function. However, excess free radical production originating from endogenous or exogenous sources might play a role in many diseases. Antioxidants prevent free radical induced tissue damage by preventing the formation of radicals, scavenging them, or by promoting their decomposition. This article reviews the basic chemistry of free radical formation in the body, the consequences of free radical induced tissue damage, and the function of antioxidant defence systems, with particular reference to the development of atherosclerosis.

Key Words: free radicals • antioxidants • oxidative stress • coronary heart disease • atherosclerosis

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Selected References

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Figures and Tables

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Figure 1 Major sources of free radicals in the body and the consequences of free radical damage.
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Figure 2 Antioxidant defences against free radical attack. Antioxidant enzymes catalyse the breakdown of free radical species, usually in the intracellular environment. Transition metal binding proteins prevent the interaction of transition metals such ...

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Group


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