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Clin Microbiol Rev. Jul 1996; 9(3): 293–300.
PMCID: PMC172894

Current status of poliovirus infections.


Two scientists who played leading roles in the conquest of poliomyelitis died recently. In 1954, Jonas Salk provided the first licensed polio vaccine, the formalin (and heat)-inactivated virus. Albert Sabin gave us the attenuated live virus vaccine, which was licensed in 1962. This paper takes the reader through the history of the disease, including its pathogenesis, epidemiology, vaccines, and future directions. The emphasis is on vaccines, for it seems that with proper vaccination the number of new cases is falling dramatically. It is hoped that by the year 2000, we will accomplish the goal of the World Health Organization of "a world without polio." Then, because there is no animal reservoir, we can seriously discuss when and how to eliminate the need for vaccination and ultimately destroy our stocks of poliovirus.

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Selected References

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  • Abe S, Ota Y, Koike S, Kurata T, Horie H, Nomura T, Hashizume S, Nomoto A. Neurovirulence test for oral live poliovaccines using poliovirus-sensitive transgenic mice. Virology. 1995 Feb 1;206(2):1075–1083. [PubMed]
  • Burke KL, Almond JW, Evans DJ. Antigen chimeras of poliovirus. Prog Med Virol. 1991;38:56–68. [PubMed]
  • Furione M, Guillot S, Otelea D, Balanant J, Candrea A, Crainic R. Polioviruses with natural recombinant genomes isolated from vaccine-associated paralytic poliomyelitis. Virology. 1993 Sep;196(1):199–208. [PubMed]
  • Goldblum N, Gerichter CB, Tulchinsky TH, Melnick JL. Poliomyelitis control in Israel, the West Bank and Gaza Strip: changing strategies with the goal of eradication in an endemic area. Bull World Health Organ. 1994;72(5):783–796. [PMC free article] [PubMed]
  • KOPROWSKI H, JERVIS GA, NORTON TW. Immune responses in human volunteers upon oral administration of a rodent-adapted strain of poliomyelitis virus. Am J Hyg. 1952 Jan;55(1):108–124. [PubMed]
  • Lasch EE, Abed Y, Abdulla K, El Tibbi AG, Marcus O, El Massri M, Handscher R, Gerichter CB, Melnick JL. Successful results of a program combining live and inactivated poliovirus vaccines to control poliomyelitis in Gaza. Rev Infect Dis. 1984 May-Jun;6 (Suppl 2):S467–S470. [PubMed]
  • MELNICK JL. Problems associated with the use of live poliovirus vaccine. Am J Public Health Nations Health. 1960 Jul;50:1013–1031. [PMC free article] [PubMed]
  • Melnick JL, Proctor RO, Ocampo AR, Diwan AR, Ben-Porath E. Free and bound virus in serum after administration of oral poliovirus vaccine. Am J Epidemiol. 1966 Sep;84(2):329–342. [PubMed]
  • Metcalf TG, Melnick JL, Estes MK. Environmental virology: from detection of virus in sewage and water by isolation to identification by molecular biology--a trip of over 50 years. Annu Rev Microbiol. 1995;49:461–487. [PubMed]
  • NOLAN JP, WILMER BH, MELNICK JL. Poliomyelitis: its highly invasive nature and narrow stream of infection in a community of high socioeconomic level. N Engl J Med. 1955 Dec 1;253(22):945–954. [PubMed]
  • Ogra PL, Faden HS, Abraham R, Duffy LC, Sun M, Minor PD. Effect of prior immunity on the shedding of virulent revertant virus in feces after oral immunization with live attenuated poliovirus vaccines. J Infect Dis. 1991 Jul;164(1):191–194. [PubMed]
  • PAUL JR, RIORDAN JT, MELNICK JL. Antibodies to three different antigenic types of poliomyelitis virus in sera from North Alaskan Eskimos. Am J Hyg. 1951 Sep;54(2):275–285. [PubMed]
  • Ren R, Racaniello VR. Human poliovirus receptor gene expression and poliovirus tissue tropism in transgenic mice. J Virol. 1992 Jan;66(1):296–304. [PMC free article] [PubMed]
  • Rezapkin GV, Chumakov KM, Lu Z, Ran Y, Dragunsky EM, Levenbook IS. Microevolution of Sabin 1 strain in vitro and genetic stability of oral poliovirus vaccine. Virology. 1994 Jul;202(1):370–378. [PubMed]
  • Rezapkin GV, Norwood LP, Taffs RE, Dragunsky EM, Levenbook IS, Chumakov KM. Microevolution of type 3 Sabin strain of poliovirus in cell cultures and its implications for oral poliovirus vaccine quality control. Virology. 1995 Aug 20;211(2):377–384. [PubMed]
  • Sabin AB. Paralytic poliomyelitis: Old dogmas and new perspectives. Rev Infect Dis. 1981 May-Jun;3(3):543–564. [PubMed]
  • SABIN AB, HENNESSEN WA, WINSSER J. Studies on variants of poliomyelitis virus. I. Experimental segregation and properties of avirulent variants of three immunologic types. J Exp Med. 1954 Jun 1;99(6):551–576. [PMC free article] [PubMed]
  • von Magnus H, Petersen I. Vaccination with inactivated poliovirus vaccine and oral poliovirus vaccine in Denmark. Rev Infect Dis. 1984 May-Jun;6 (Suppl 2):S471–S474. [PubMed]
  • Ward R, Melnick JL, Horstmann DM. POLIOMYELITIS VIRUS IN FLY-CONTAMINATED FOOD COLLECTED AT AN EPIDEMIC. Science. 1945 May 11;101(2628):491–493. [PubMed]

Articles from Clinical Microbiology Reviews are provided here courtesy of American Society for Microbiology (ASM)


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