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Br J Sports Med. 2003 Feb; 37(1): 76–79.
PMCID: PMC1724582

Effects of 12 months of exercise training on salivary secretory IgA levels in elderly subjects


Background: The immune system declines in efficiency with advancing age, making the elderly less resistant to pathogenic microorganisms. Upper respiratory tract infection (URTI) is a common illness. Recent studies have shown that suppression of secretory immunoglobulin A (SIgA) is associated with increased incidence of URTI.

Objective: To assess the effect of exercise on salivary SIgA in elderly subjects.

Methods: Forty five elderly subjects (18 men, 27 women; mean (SD) age 64.9 (8.4) years) performed both 60 minute resistance and 60 minute moderate endurance training a week for 12 months. Saliva samples were obtained before training, and at four and 12 months during the training period. Salivary SIgA concentrations were measured by enzyme linked immunosorbent assay, and the SIgA secretion rate was calculated.

Results: SIgA concentrations before training, and at four and 12 months during training were 24.7 (14.4), 27.2 (14.2), and 33.8 (18.5) µg/ml respectively. SIgA secretion rates were 29.5 (26.0), 33.8 (27.2) and 46.5 (35.1) µg/min respectively. The results indicate that both the concentration and secretion rate of SIgA significantly (p<0.01) increased during 12 months of exercise in these elderly subjects.

Conclusion: Regular moderate exercise seems to enhance mucosal immune function in elderly subjects.

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Selected References

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  • Shephard RJ, Shek PN. Exercise, aging and immune function. Int J Sports Med. 1995 Jan;16(1):1–6. [PubMed]
  • Nieman DC, Henson DA, Gusewitch G, Warren BJ, Dotson RC, Butterworth DE, Nehlsen-Cannarella SL. Physical activity and immune function in elderly women. Med Sci Sports Exerc. 1993 Jul;25(7):823–831. [PubMed]
  • Houston MS, Silverstein MD, Suman VJ. Risk factors for 30-day mortality in elderly patients with lower respiratory tract infection. Community-based study. Arch Intern Med. 1997 Oct 27;157(19):2190–2195. [PubMed]
  • Heath GW, Ford ES, Craven TE, Macera CA, Jackson KL, Pate RR. Exercise and the incidence of upper respiratory tract infections. Med Sci Sports Exerc. 1991 Feb;23(2):152–157. [PubMed]
  • Mackinnon LT, Hooper S. Mucosal (secretory) immune system responses to exercise of varying intensity and during overtraining. Int J Sports Med. 1994 Oct;15 (Suppl 3):S179–S183. [PubMed]
  • Peters EM, Bateman ED. Ultramarathon running and upper respiratory tract infections. An epidemiological survey. S Afr Med J. 1983 Oct 1;64(15):582–584. [PubMed]
  • Peters EM, Goetzsche JM, Grobbelaar B, Noakes TD. Vitamin C supplementation reduces the incidence of postrace symptoms of upper-respiratory-tract infection in ultramarathon runners. Am J Clin Nutr. 1993 Feb;57(2):170–174. [PubMed]
  • Nieman DC. Exercise, upper respiratory tract infection, and the immune system. Med Sci Sports Exerc. 1994 Feb;26(2):128–139. [PubMed]
  • Gleeson M, McDonald WA, Pyne DB, Cripps AW, Francis JL, Fricker PA, Clancy RL. Salivary IgA levels and infection risk in elite swimmers. Med Sci Sports Exerc. 1999 Jan;31(1):67–73. [PubMed]
  • Tomasi TB. The discovery of secretory IgA and the mucosal immune system. Immunol Today. 1992 Oct;13(10):416–418. [PubMed]
  • McDowell SL, Hughes RA, Hughes RJ, Housh TJ, Johnson GO. The effect of exercise training on salivary immunoglobulin A and cortisol responses to maximal exercise. Int J Sports Med. 1992 Nov;13(8):577–580. [PubMed]
  • Tomasi TB, Trudeau FB, Czerwinski D, Erredge S. Immune parameters in athletes before and after strenuous exercise. J Clin Immunol. 1982 Jul;2(3):173–178. [PubMed]
  • Chandler JM, Hadley EC. Exercise to improve physiologic and functional performance in old age. Clin Geriatr Med. 1996 Nov;12(4):761–784. [PubMed]
  • Fiatarone MA, Marks EC, Ryan ND, Meredith CN, Lipsitz LA, Evans WJ. High-intensity strength training in nonagenarians. Effects on skeletal muscle. JAMA. 1990 Jun 13;263(22):3029–3034. [PubMed]
  • Green JS, Crouse SF. The effects of endurance training on functional capacity in the elderly: a meta-analysis. Med Sci Sports Exerc. 1995 Jun;27(6):920–926. [PubMed]
  • Flynn MG, Fahlman M, Braun WA, Lambert CP, Bouillon LE, Brolinson PG, Armstrong CW. Effects of resistance training on selected indexes of immune function in elderly women. J Appl Physiol (1985) 1999 Jun;86(6):1905–1913. [PubMed]
  • Mazzeo RS. The influence of exercise and aging on immune function. Med Sci Sports Exerc. 1994 May;26(5):586–592. [PubMed]
  • Shinkai S, Kohno H, Kimura K, Komura T, Asai H, Inai R, Oka K, Kurokawa Y, Shephard R. Physical activity and immune senescence in men. Med Sci Sports Exerc. 1995 Nov;27(11):1516–1526. [PubMed]
  • Crist DM, Mackinnon LT, Thompson RF, Atterbom HA, Egan PA. Physical exercise increases natural cellular-mediated tumor cytotoxicity in elderly women. Gerontology. 1989;35(2-3):66–71. [PubMed]
  • KARVONEN MJ, KENTALA E, MUSTALA O. The effects of training on heart rate; a longitudinal study. Ann Med Exp Biol Fenn. 1957;35(3):307–315. [PubMed]
  • Shindo M, Kumagai S, Tanaka H. Physical work capacity and effect of endurance training in visually handicapped boys and young male adults. Eur J Appl Physiol Occup Physiol. 1987;56(5):501–507. [PubMed]
  • Sugi H, Akimoto T, Chaen S, Suzuki S. ATP-induced axial movement of myosin heads in living thick filaments recorded with a gas environmental chamber attached to the electron microscope. Adv Exp Med Biol. 1998;453:53–62. [PubMed]
  • MacKinnon LT, Jenkins DG. Decreased salivary immunoglobulins after intense interval exercise before and after training. Med Sci Sports Exerc. 1993 Jun;25(6):678–683. [PubMed]
  • Nehlsen-Cannarella SL, Nieman DC, Balk-Lamberton AJ, Markoff PA, Chritton DB, Gusewitch G, Lee JW. The effects of moderate exercise training on immune response. Med Sci Sports Exerc. 1991 Jan;23(1):64–70. [PubMed]
  • Miletic ID, Schiffman SS, Miletic VD, Sattely-Miller EA. Salivary IgA secretion rate in young and elderly persons. Physiol Behav. 1996 Jul;60(1):243–248. [PubMed]

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