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Br J Ophthalmol. Jun 1999; 83(6): 742–747.
PMCID: PMC1723071

Ocular adnexal lymphoma—comparison of MALT lymphoma with other histological types

Abstract

AIMS—To correlate histological features of ocular adnexal lymphoma using the revised European American lymphoma classification (REAL), with stage of disease at presentation, treatment modalities, and patient outcome. MALT lymphoma defines an extranodal marginal zone B cell lymphoma as outlined in the REAL classification. Comparison groups of patients included those with primary ocular adnexal MALT lymphoma versus primary ocular adnexal lymphomas of other types, MALT lymphoma versus non-MALT lymphomas (primary and secondary), and primary ocular adnexal lymphoma (MALT lymphomas and other types) versus secondary ocular adnexal lymphomas.
METHODS—A retrospective review of the National Ophthalmic Pathology Laboratory records identified 20 cases of ocular adnexal lymphoma over a 10 year period which were reclassified using appropriate immunohistochemical stains. Patients' medical records were examined for data including stage of the disease at presentation, mode of treatment, and patient outcome.
RESULTS—Among the 20 cases identified 14 had primary ocular adnexal lymphomas. 10 of the primary lymphomas had histological features of MALT lymphoma. One case was a primary ocular adnexal T cell lymphoma, one a follicular centre, follicular B cell lymphoma, and two were large cell B cell lymphomas. Six cases had systemic disease, four large B cell, one follicular centre, follicular B cell, and one mantle cell. A significantly higher proportion of patients with MALT lymphomas had early disease (p = 0.005), initially required local treatment (p = 0.005) and were alive at last follow up (p = 0.001) than those without. Two patients with MALT lymphoma had recurrence of lymphoma which responded to further treatment.
CONCLUSIONS—Patients with primary ocular adnexal MALT lymphomas present with localised disease requiring local treatment and have a better outcome compared with patients with other types. As a small percentage of these tumours recur, patients should be followed up indefinitely.

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Selected References

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  • Stansfeld AG, Diebold J, Noel H, Kapanci Y, Rilke F, Kelényi G, Sundstrom C, Lennert K, van Unnik JA, Mioduszewska O, et al. Updated Kiel classification for lymphomas. Lancet. 1988 Feb 6;1(8580):292–293. [PubMed]
  • Freeman C, Berg JW, Cutler SJ. Occurrence and prognosis of extranodal lymphomas. Cancer. 1972 Jan;29(1):252–260. [PubMed]
  • Banfi A, Bonadonna G, Carnevali G, Oldini C, Salvini E. Preferential sites of involvement and spread in maignant lymphomas. Eur J Cancer. 1968 Jul;4(3):319–324. [PubMed]
  • Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML, Delsol G, De Wolf-Peeters C, Falini B, Gatter KC, et al. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood. 1994 Sep 1;84(5):1361–1392. [PubMed]
  • Isaacson P, Wright DH. Malignant lymphoma of mucosa-associated lymphoid tissue. A distinctive type of B-cell lymphoma. Cancer. 1983 Oct 15;52(8):1410–1416. [PubMed]
  • Isaacson P, Wright DH. Extranodal malignant lymphoma arising from mucosa-associated lymphoid tissue. Cancer. 1984 Jun 1;53(11):2515–2524. [PubMed]
  • Myhre MJ, Isaacson PG. Primary B-cell gastric lymphoma--a reassessment of its histogenesis. J Pathol. 1987 May;152(1):1–11. [PubMed]
  • Addis BJ, Hyjek E, Isaacson PG. Primary pulmonary lymphoma: a re-appraisal of its histogenesis and its relationship to pseudolymphoma and lymphoid interstitial pneumonia. Histopathology. 1988 Jul;13(1):1–17. [PubMed]
  • Hyjek E, Smith WJ, Isaacson PG. Primary B-cell lymphoma of salivary glands and its relationship to myoepithelial sialadenitis. Hum Pathol. 1988 Jul;19(7):766–776. [PubMed]
  • Hyjek E, Isaacson PG. Primary B cell lymphoma of the thyroid and its relationship to Hashimoto's thyroiditis. Hum Pathol. 1988 Nov;19(11):1315–1326. [PubMed]
  • Wotherspoon AC, Diss TC, Pan LX, Schmid C, Kerr-Muir MG, Lea SH, Isaacson PG. Primary low-grade B-cell lymphoma of the conjunctiva: a mucosa-associated lymphoid tissue type lymphoma. Histopathology. 1993 Nov;23(5):417–424. [PubMed]
  • Li G, Hansmann ML, Zwingers T, Lennert K. Primary lymphomas of the lung: morphological, immunohistochemical and clinical features. Histopathology. 1990 Jun;16(6):519–531. [PubMed]
  • Isaacson PG. Lymphomas of mucosa-associated lymphoid tissue (MALT). Histopathology. 1990 Jun;16(6):617–619. [PubMed]
  • Jakobiec FA, Iwamoto T, Patell M, Knowles DM., 2nd Ocular adnexal monoclonal lymphoid tumors with a favorable prognosis. Ophthalmology. 1986 Dec;93(12):1547–1557. [PubMed]
  • White WL, Ferry JA, Harris NL, Grove AS., Jr Ocular adnexal lymphoma. A clinicopathologic study with identification of lymphomas of mucosa-associated lymphoid tissue type. Ophthalmology. 1995 Dec;102(12):1994–2006. [PubMed]
  • Bessell EM, Henk JM, Wright JE, Whitelocke RA. Orbital and conjunctival lymphoma treatment and prognosis. Radiother Oncol. 1988 Dec;13(4):237–244. [PubMed]
  • Reddy EK, Bhatia P, Evans RG. Primary orbital lymphomas. Int J Radiat Oncol Biol Phys. 1988 Nov;15(5):1239–1241. [PubMed]
  • Morgan G, Harry J. Lymphocytic tumours of indeterminate nature: a 5-year follow-up of 98 conjunctival and orbital lesions. Br J Ophthalmol. 1978 Jun;62(6):381–383. [PMC free article] [PubMed]
  • Ellis JH, Banks PM, Campbell RJ, Liesegang TJ. Lymphoid tumors of the ocular adnexa. Clinical correlation with the working formulation classification and immunoperoxidase staining of paraffin sections. Ophthalmology. 1985 Oct;92(10):1311–1324. [PubMed]
  • McNally L, Jakobiec FA, Knowles DM., 2nd Clinical, morphologic, immunophenotypic, and molecular genetic analysis of bilateral ocular adnexal lymphoid neoplasms in 17 patients. Am J Ophthalmol. 1987 Apr 15;103(4):555–568. [PubMed]
  • Medeiros LJ, Harris NL. Lymphoid infiltrates of the orbit and conjunctiva. A morphologic and immunophenotypic study of 99 cases. Am J Surg Pathol. 1989 Jun;13(6):459–471. [PubMed]
  • Knowles DM, Jakobiec FA, McNally L, Burke JS. Lymphoid hyperplasia and malignant lymphoma occurring in the ocular adnexa (orbit, conjunctiva, and eyelids): a prospective multiparametric analysis of 108 cases during 1977 to 1987. Hum Pathol. 1990 Sep;21(9):959–973. [PubMed]
  • Jakobiec FA, McLean I, Font RL. Clinicopathologic characteristics of orbital lymphoid hyperplasia. Ophthalmology. 1979 May;86(5):948–966. [PubMed]
  • Hsu SM, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem. 1981 Apr;29(4):577–580. [PubMed]
  • Meekins B, Proia AD, Klintworth GK. Cutaneous T-cell lymphoma presenting as a rapidly enlarging ocular adnexal tumor. Ophthalmology. 1985 Sep;92(9):1288–1293. [PubMed]
  • Laroche L, Laroche L, Pavlakis E, Saraux H. Immunological characterization of an ocular adnexal lymphoid T tumor by monoclonal antibodies. Ophthalmologica. 1983;187(1):43–49. [PubMed]
  • Goudie RB, Macfarlane PS, Lindsay MK. Homing of lymphocytes to non-lymphoid tissues. Lancet. 1974 Feb 23;1(7852):292–293. [PubMed]
  • Pals ST, Horst E, Scheper RJ, Meijer CJ. Mechanisms of human lymphocyte migration and their role in the pathogenesis of disease. Immunol Rev. 1989 Apr;108:111–133. [PubMed]

Figures and Tables

Figure 1
(A) Photomicrograph of conjunctival MALT lymphoma, demonstrating a monotonous infiltrate of small round and small cleaved lymphocytes. The remnant of a pre-existing germinal centre has been colonised by tumour cells (large arrow) (haematoxylin and eosin ...

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