• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of brjopthalBritish Journal of OphthalmologyCurrent TOCInstructions for authors
Br J Ophthalmol. Nov 1997; 81(11): 962–964.
PMCID: PMC1722041

Endogenous cortisol profile in patients with central serous chorioretinopathy

Abstract

AIM—To study the endogenous cortisol levels in patients with central serous chorioretinopathy (CSCR).
METHODS—Endogenous cortisol levels in urine and plasma were determined in 30 patients with acute CSCR and compared with 30 age and sex matched controls.
RESULTS—The mean values of the 8 am plasma cortisol (29.97 µg/dl v 18.76 µg/dl), 11 pm plasma cortisol (22.03 µg/dl v 13.06 µg/dl), and 24 hour urine cortisol (11.01 mg/24 h v 7.39 mg/24 h) revealed significantly higher values in the patient group (p<0.001).
CONCLUSIONS—Increased levels of endogenous cortisol are present in patients with CSCR.

Full Text

The Full Text of this article is available as a PDF (70K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Guyer DR, Yannuzzi LA, Slakter JS, Sorenson JA, Ho A, Orlock D. Digital indocyanine green videoangiography of central serous chorioretinopathy. Arch Ophthalmol. 1994 Aug;112(8):1057–1062. [PubMed]
  • Diddie KR, Aronson AJ, Ernest JT. Chorioretinopathy in a case of systemic lupus erythematosus. Trans Am Ophthalmol Soc. 1977;75:122–131. [PMC free article] [PubMed]
  • Eckstein MB, Spalton DJ, Holder G. Visual loss from central serous retinopathy in systemic lupus erythematosus. Br J Ophthalmol. 1993 Sep;77(9):607–609. [PMC free article] [PubMed]
  • KLIEN BA. Macular and extramacular serous chorieretinopathy. With remarks upon the role of an extrabulbar mechanism in its pathogenesis. Am J Ophthalmol. 1961 Feb;51:231–242. [PubMed]
  • Dellaporta A. Central serous retinopathy. Trans Am Ophthalmol Soc. 1976;74:144–153. [PMC free article] [PubMed]
  • Bouzas EA, Scott MH, Mastorakos G, Chrousos GP, Kaiser-Kupfer MI. Central serous chorioretinopathy in endogenous hypercortisolism. Arch Ophthalmol. 1993 Sep;111(9):1229–1233. [PubMed]
  • Gass JD. Central serous chorioretinopathy and white subretinal exudation during pregnancy. Arch Ophthalmol. 1991 May;109(5):677–681. [PubMed]
  • Wakakura M, Ishikawa S. Central serous chorioretinopathy complicating systemic corticosteroid treatment. Br J Ophthalmol. 1984 May;68(5):329–331. [PMC free article] [PubMed]
  • Gelber GS, Schatz H. Loss of vision due to central serous chorioretinopathy following psychological stress. Am J Psychiatry. 1987 Jan;144(1):46–50. [PubMed]
  • Chumbley LC, Frank RN. Central serous retinopathy and pregnancy. Am J Ophthalmol. 1974 Feb;77(2):158–160. [PubMed]
  • Yannuzzi LA. Type-A behavior and central serous chorioretinopathy. Retina. 1987 Summer;7(2):111–131. [PubMed]
  • Chrousos GP, Gold PW. The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA. 1992 Mar 4;267(9):1244–1252. [PubMed]
  • Doe RP, Dickinson P, Zinneman HH, Seal US. Elevated nonprotein-bound cortisol (NPC) in pregnancy, during estrogen administration and in carcinoma of the prostate. J Clin Endocrinol Metab. 1969 Jun;29(6):757–766. [PubMed]
  • Luger A, Deuster PA, Kyle SB, Gallucci WT, Montgomery LC, Gold PW, Loriaux DL, Chrousos GP. Acute hypothalamic-pituitary-adrenal responses to the stress of treadmill exercise. Physiologic adaptations to physical training. N Engl J Med. 1987 May 21;316(21):1309–1315. [PubMed]
  • Nolten WE, Rueckert PA, Lindheimer MD, Oparil S, Ehrlich EN. A simple method for determining the free cortisol index in plasma: measurements in human pregnancy. J Lab Clin Med. 1979 Jan;93(1):146–153. [PubMed]
  • Williams RB, Jr, Lane JD, Kuhn CM, Melosh W, White AD, Schanberg SM. Type A behavior and elevated physiological and neuroendocrine responses to cognitive tasks. Science. 1982 Oct 29;218(4571):483–485. [PubMed]
  • Jain IS, Singh K. Maculopathy a corticosteroid side-effect. J All India Ophthalmol Soc. 1966 Dec;14(6):250–252. [PubMed]
  • Cruysberg JR, Deutman AF. Visual disturbances during pregnancy caused by central serous choroidopathy. Br J Ophthalmol. 1982 Apr;66(4):240–241. [PMC free article] [PubMed]
  • Smith TJ. Dexamethasone regulation of glycosaminoglycan synthesis in cultured human skin fibroblasts. Similar effects of glucocorticoid and thyroid hormones. J Clin Invest. 1984 Dec;74(6):2157–2163. [PMC free article] [PubMed]
  • Ehrlich HP, Tarver H, Hunt TK. Effects of vitamin A and glucocorticoids upon inflammation and collagen synthesis. Ann Surg. 1973 Feb;177(2):222–227. [PMC free article] [PubMed]
  • Pratt WB, Aronow L. The effect of glucocorticoids on protein and nucleic acid synthesis in mouse fibroblasts growing in vitro. J Biol Chem. 1966 Nov 25;241(22):5244–5250. [PubMed]
  • Cupps TR, Gerrard TL, Falkoff RJ, Whalen G, Fauci AS. Effects of in vitro corticosteroids on B cell activation, proliferation, and differentiation. J Clin Invest. 1985 Feb;75(2):754–761. [PMC free article] [PubMed]
  • Yu DT, Clements PJ, Paulus HE, Peter JB, Levy J, Barnett EV. Human lymphocyte subpopulations. Effect of corticosteroids. J Clin Invest. 1974 Feb;53(2):565–571. [PMC free article] [PubMed]
  • Rinehart JJ, Sagone AL, Balcerzak SP, Ackerman GA, LoBuglio AF. Effects of corticosteroid therapy on human monocyte function. N Engl J Med. 1975 Jan 30;292(5):236–241. [PubMed]
  • Sandle GI, McGlone F. Acute effects of dexamethasone on cation transport in colonic epithelium. Gut. 1987 Jun;28(6):701–706. [PMC free article] [PubMed]
  • Smith PR, Benos DJ. Epithelial Na+ channels. Annu Rev Physiol. 1991;53:509–530. [PubMed]

Articles from The British Journal of Ophthalmology are provided here courtesy of BMJ Group

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Compound
    Compound
    PubChem Compound links
  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...