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Antimicrob Agents Chemother. 1988 Feb; 32(2): 285–286.
PMCID: PMC172156

Chloramphenicol, gentamicin, and ciprofloxacin against murine scrub typhus.


Ciprofloxacin (120 mg/kg of body weight per day), chloramphenicol (300 mg/kg per day), and gentamicin (30 mg/kg per day) were compared with placebo in a BALB/cj mouse model of scrub typhus. All animals treated with ciprofloxacin and chloramphenicol survived. All animals treated with gentamicin or placebo died. All surviving animals showed evidence of seroconversion. Ciprofloxacin and chloramphenicol were statistically more effective in preventing death than gentamicin or placebo.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Raoult D, Gallais H, De Micco P, Casanova P. Ciprofloxacin therapy for Mediterranean spotted fever. Antimicrob Agents Chemother. 1986 Oct;30(4):606–607. [PMC free article] [PubMed]
  • Tribby II, Friis RR, Moulder JW. Effect of chloramphenicol, rifampicin, and nalidixic acid on Chlamydia psittaci growing in L cells. J Infect Dis. 1973 Feb;127(2):155–163. [PubMed]
  • Wisseman CL, Jr, Waddell AD, Walsh WT. In vitro studies of the action of antibiotics on Rickettsia prowazeki by two basic methods of cell culture. J Infect Dis. 1974 Dec;130(6):564–574. [PubMed]

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