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Logo of archdischfnArchives of Disease in Childhood - Fetal & NeonatalView this articleSubmit a manuscriptReceive email alertsContact usBMJ
Arch Dis Child Fetal Neonatal Ed. Jul 1999; 81(1): F71–F73.
PMCID: PMC1720972

Low birthweight and adult insulin resistance: the "catch-up growth" hypothesis

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Selected References

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  • Barker DJ, Winter PD, Osmond C, Margetts B, Simmonds SJ. Weight in infancy and death from ischaemic heart disease. Lancet. 1989 Sep 9;2(8663):577–580. [PubMed]
  • Law CM, Barker DJ, Bull AR, Osmond C. Maternal and fetal influences on blood pressure. Arch Dis Child. 1991 Nov;66(11):1291–1295. [PMC free article] [PubMed]
  • Robinson S, Walton RJ, Clark PM, Barker DJ, Hales CN, Osmond C. The relation of fetal growth to plasma glucose in young men. Diabetologia. 1992 May;35(5):444–446. [PubMed]
  • Barker DJ. Fetal origins of coronary heart disease. BMJ. 1995 Jul 15;311(6998):171–174. [PMC free article] [PubMed]
  • Barker DJ. Intrauterine programming of coronary heart disease and stroke. Acta Paediatr Suppl. 1997 Nov;423:178–183. [PubMed]
  • Ravelli AC, van der Meulen JH, Michels RP, Osmond C, Barker DJ, Hales CN, Bleker OP. Glucose tolerance in adults after prenatal exposure to famine. Lancet. 1998 Jan 17;351(9097):173–177. [PubMed]
  • Hales CN, Barker DJ. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia. 1992 Jul;35(7):595–601. [PubMed]
  • Hofman PL, Cutfield WS, Robinson EM, Bergman RN, Menon RK, Sperling MA, Gluckman PD. Insulin resistance in short children with intrauterine growth retardation. J Clin Endocrinol Metab. 1997 Feb;82(2):402–406. [PubMed]
  • Barker DJ, Hales CN, Fall CH, Osmond C, Phipps K, Clark PM. Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia. 1993 Jan;36(1):62–67. [PubMed]
  • Simmons RA, Gounis AS, Bangalore SA, Ogata ES. Intrauterine growth retardation: fetal glucose transport is diminished in lung but spared in brain. Pediatr Res. 1992 Jan;31(1):59–63. [PubMed]
  • Simmons RA, Flozak AS, Ogata ES. The effect of insulin and insulin-like growth factor-I on glucose transport in normal and small for gestational age fetal rats. Endocrinology. 1993 Sep;133(3):1361–1368. [PubMed]
  • Cianfarani S, Holly JM. Somatomedin-binding proteins: what role do they play in the growth process? Eur J Pediatr. 1989 Nov;149(2):76–79. [PubMed]
  • Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev. 1995 Feb;16(1):3–34. [PubMed]
  • Kim HS, Nagalla SR, Oh Y, Wilson E, Roberts CT, Jr, Rosenfeld RG. Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): characterization of connective tissue growth factor as a member of the IGFBP superfamily. Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):12981–12986. [PMC free article] [PubMed]
  • Rajaram S, Baylink DJ, Mohan S. Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions. Endocr Rev. 1997 Dec;18(6):801–831. [PubMed]
  • Lewitt MS, Denyer GS, Cooney GJ, Baxter RC. Insulin-like growth factor-binding protein-1 modulates blood glucose levels. Endocrinology. 1991 Oct;129(4):2254–2256. [PubMed]
  • Gluckman PD, Johnson-Barrett JJ, Butler JH, Edgar BW, Gunn TR. Studies of insulin-like growth factor -I and -II by specific radioligand assays in umbilical cord blood. Clin Endocrinol (Oxf) 1983 Sep;19(3):405–413. [PubMed]
  • Lassarre C, Hardouin S, Daffos F, Forestier F, Frankenne F, Binoux M. Serum insulin-like growth factors and insulin-like growth factor binding proteins in the human fetus. Relationships with growth in normal subjects and in subjects with intrauterine growth retardation. Pediatr Res. 1991 Mar;29(3):219–225. [PubMed]
  • Verhaeghe J, Van Bree R, Van Herck E, Laureys J, Bouillon R, Van Assche FA. C-peptide, insulin-like growth factors I and II, and insulin-like growth factor binding protein-1 in umbilical cord serum: correlations with birth weight. Am J Obstet Gynecol. 1993 Jul;169(1):89–97. [PubMed]
  • Giudice LC, de Zegher F, Gargosky SE, Dsupin BA, de las Fuentes L, Crystal RA, Hintz RL, Rosenfeld RG. Insulin-like growth factors and their binding proteins in the term and preterm human fetus and neonate with normal and extremes of intrauterine growth. J Clin Endocrinol Metab. 1995 May;80(5):1548–1555. [PubMed]
  • Hills FA, English J, Chard T. Circulating levels of IGF-I and IGF-binding protein-1 throughout pregnancy: relation to birthweight and maternal weight. J Endocrinol. 1996 Feb;148(2):303–309. [PubMed]
  • Liu JP, Baker J, Perkins AS, Robertson EJ, Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell. 1993 Oct 8;75(1):59–72. [PubMed]
  • Baker J, Liu JP, Robertson EJ, Efstratiadis A. Role of insulin-like growth factors in embryonic and postnatal growth. Cell. 1993 Oct 8;75(1):73–82. [PubMed]
  • Woods KA, Camacho-Hübner C, Savage MO, Clark AJ. Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene. N Engl J Med. 1996 Oct 31;335(18):1363–1367. [PubMed]
  • Langford KS, Nicolaides KH, Jones J, Abbas A, McGregor AM, Miell JP. Serum insulin-like growth factor-binding protein-3 (IGFBP-3) levels and IGFBP-3 protease activity in normal, abnormal, and multiple human pregnancy. J Clin Endocrinol Metab. 1995 Jan;80(1):21–27. [PubMed]
  • Cianfarani S, Germani D, Rossi P, Rossi L, Germani A, Ossicini C, Zuppa A, Argirò G, Holly JM, Branca F. Intrauterine growth retardation: evidence for the activation of the insulin-like growth factor (IGF)-related growth-promoting machinery and the presence of a cation-independent IGF binding protein-3 proteolytic activity by two months of life. Pediatr Res. 1998 Sep;44(3):374–380. [PubMed]
  • Leger J, Noel M, Limal JM, Czernichow P. Growth factors and intrauterine growth retardation. II. Serum growth hormone, insulin-like growth factor (IGF) I, and IGF-binding protein 3 levels in children with intrauterine growth retardation compared with normal control subjects: prospective study from birth to two years of age. Study Group of IUGR. Pediatr Res. 1996 Jul;40(1):101–107. [PubMed]
  • Karlberg J, Albertsson-Wikland K. Growth in full-term small-for-gestational-age infants: from birth to final height. Pediatr Res. 1995 Nov;38(5):733–739. [PubMed]
  • Hales CN, Desai M, Ozanne SE, Crowther NJ. Fishing in the stream of diabetes: from measuring insulin to the control of fetal organogenesis. Biochem Soc Trans. 1996 May;24(2):341–350. [PubMed]
  • Colle E, Schiff D, Andrew G, Bauer CB, Fitzhardinge P. Insulin responses during catch-up growth of infants who were small for gestational age. Pediatrics. 1976 Mar;57(3):363–371. [PubMed]
  • Yamanaka Y, Wilson EM, Rosenfeld RG, Oh Y. Inhibition of insulin receptor activation by insulin-like growth factor binding proteins. J Biol Chem. 1997 Dec 5;272(49):30729–30734. [PubMed]
  • Whitaker RC, Pepe MS, Wright JA, Seidel KD, Dietz WH. Early adiposity rebound and the risk of adult obesity. Pediatrics. 1998 Mar;101(3):E5–E5. [PubMed]
  • Rolland-Cachera MF, Deheeger M, Bellisle F, Sempé M, Guilloud-Bataille M, Patois E. Adiposity rebound in children: a simple indicator for predicting obesity. Am J Clin Nutr. 1984 Jan;39(1):129–135. [PubMed]

Articles from Archives of Disease in Childhood. Fetal and Neonatal Edition are provided here courtesy of BMJ Group


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