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Logo of archdischfnArchives of Disease in Childhood - Fetal & NeonatalView this articleSubmit a manuscriptReceive email alertsContact usBMJ
Arch Dis Child Fetal Neonatal Ed. Jul 1999; 81(1): F10–F14.
PMCID: PMC1720965

Neurodevelopmental outcome at early school age of children born to mothers with gestational diabetes


AIMS—To study the metabolic derangements in the second half of pregnancy caused by gestational diabetes, on the long term development of children.
METHODS—The neuropsychological function of 32 school age children born to 32 mothers with well controlled gestational diabetes and 57 control children matched by age, birth order, and parental socioeconomic status was studied.
RESULTS—There were no differences in head circumference and height, but the children born to diabetic mothers were heavier. The verbal IQ scores of index children below the age of 9 years were lower than those of control children. No differences were found between the groups in various sensory and motor functions and in the Touwen and Prechtl neurological test. The young index group children performed less well than controls in fine and gross motor functions, as observed on the Bruininks-Oseretzky test of motor proficiency. The scores of young children born to mothers with gestational diabetes were also lower than controls on the Pollack tapper test, and there were more index group children who scored abnormally on the parents' Conners questionnaire. No correlation was found between the performance of the index group children on various neurodevelopmental tests and the severity of perinatal complications. The differences tended to disappear with age.
CONCLUSIONS—Gestational diabetes, as a result of the metabolic abnormalities in the second half of pregnancy, induces long term minor neurological deficits which are more pronounced in younger children. There does not seem to be any direct relation between the appearance of congenital anomalies and neurodevelopmental outcome.

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Selected References

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  • Eskes TK, Mooij PN, Steegers-Theunissen RP, Lips JP, Pasker-de Jong PC. Prepregnancy care and prevention of birth defects. J Perinat Med. 1992;20(4):253–265. [PubMed]
  • Goto MP, Goldman AS. Diabetic embryopathy. Curr Opin Pediatr. 1994 Aug;6(4):486–491. [PubMed]
  • Hod M, Diamant YZ. The offspring of a diabetic mother--short- and long-range implications. Isr J Med Sci. 1992 Feb;28(2):81–86. [PubMed]
  • Miller E, Hare JW, Cloherty JP, Dunn PJ, Gleason RE, Soeldner JS, Kitzmiller JL. Elevated maternal hemoglobin A1c in early pregnancy and major congenital anomalies in infants of diabetic mothers. N Engl J Med. 1981 May 28;304(22):1331–1334. [PubMed]
  • Mills JL, Baker L, Goldman AS. Malformations in infants of diabetic mothers occur before the seventh gestational week. Implications for treatment. Diabetes. 1979 Apr;28(4):292–293. [PubMed]
  • Mills JL. Malformations in infants of diabetic mothers. Teratology. 1982 Jun;25(3):385–394. [PubMed]
  • Mills JL, Knopp RH, Simpson JL, Jovanovic-Peterson L, Metzger BE, Holmes LB, Aarons JH, Brown Z, Reed GF, Bieber FR, et al. Lack of relation of increased malformation rates in infants of diabetic mothers to glycemic control during organogenesis. N Engl J Med. 1988 Mar 17;318(11):671–676. [PubMed]
  • Miodovnik M, Mimouni F, Dignan PS, Berk MA, Ballard JL, Siddiqi TA, Khoury J, Tsang RC. Major malformations in infants of IDDM women. Vasculopathy and early first-trimester poor glycemic control. Diabetes Care. 1988 Oct;11(9):713–718. [PubMed]
  • Blumenthal SA, Abdul-Karim RW. Diagnosis, classification, and metabolic management of diabetes in pregnancy: therapeutic impact of self-monitoring of blood glucose and of newer methods of insulin delivery. Obstet Gynecol Surv. 1987 Oct;42(10):593–604. [PubMed]
  • Dobbing J, Sands J. Quantitative growth and development of human brain. Arch Dis Child. 1973 Oct;48(10):757–767. [PMC free article] [PubMed]
  • Stehbens JA, Baker GL, Kitchell M. Outcome at ages 1, 3, and 5 years of children born to diabetic women. Am J Obstet Gynecol. 1977 Feb 15;127(4):408–413. [PubMed]
  • Petersen MB, Pedersen SA, Greisen G, Pedersen JF, Mølsted-Pedersen L. Early growth delay in diabetic pregnancy: relation to psychomotor development at age 4. Br Med J (Clin Res Ed) 1988 Feb 27;296(6622):598–600. [PMC free article] [PubMed]
  • Cummins M, Norrish M. Follow-up of children of diabetic mothers. Arch Dis Child. 1980 Apr;55(4):259–264. [PMC free article] [PubMed]
  • Persson B, Gentz J. Follow-up of children of insulin-dependent and gestational diabetic mothers. Neuropsychological outcome. Acta Paediatr Scand. 1984 May;73(3):349–358. [PubMed]
  • Rizzo T, Metzger BE, Burns WJ, Burns K. Correlations between antepartum maternal metabolism and child intelligence. N Engl J Med. 1991 Sep 26;325(13):911–916. [PubMed]
  • Rizzo TA, Dooley SL, Metzger BE, Cho NH, Ogata ES, Silverman BL. Prenatal and perinatal influences on long-term psychomotor development in offspring of diabetic mothers. Am J Obstet Gynecol. 1995 Dec;173(6):1753–1758. [PubMed]
  • Ornoy A, Ratzon N, Greenbaum C, Peretz E, Soriano D, Dulitzky M. Neurobehaviour of school age children born to diabetic mothers. Arch Dis Child Fetal Neonatal Ed. 1998 Sep;79(2):F94–F99. [PMC free article] [PubMed]
  • Ornoy A, Uriel L, Tennenbaum A. Inattention, hyperactivity and speech delay at 2-4 years of age as a predictor for ADD-ADHD syndrome. Isr J Psychiatry Relat Sci. 1993;30(3):155–163. [PubMed]
  • Metzger BE, Silverman BL, Freinkel N, Dooley SL, Ogata ES, Green OC. Amniotic fluid insulin concentration as a predictor of obesity. Arch Dis Child. 1990 Oct;65(10 Spec No):1050–1052. [PMC free article] [PubMed]
  • Lambert NM, Sandoval J. The prevalence of learning disabilities in a sample of children considered hyperactive. J Abnorm Child Psychol. 1980 Mar;8(1):33–50. [PubMed]
  • Silverman BL, Landsberg L, Metzger BE. Fetal hyperinsulinism in offspring of diabetic mothers. Association with the subsequent development of childhood obesity. Ann N Y Acad Sci. 1993 Oct 29;699:36–45. [PubMed]

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