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Arch Dis Child Fetal Neonatal Ed. 1998 July; 79(1): F61–F63. | PMCID: PMC1720809 |
Nasal high frequency ventilation in neonates with moderate
respiratory insufficiency M. van der Hoeven, E. Brouwer, and C. Blanco AIM—To investigate the
efficacy of nasal high frequency ventilation (nHFV) in newborn infants
with moderate respiratory insufficiency.
METHOD—Twenty
one preterm and term neonates were treated with nHFV for respiratory
insufficiency. Criteria for starting nHFV were: deterioration on nasal
CPAP expressed by a median pH of 7.24 and pCO2 of 8.3 kPa,
or increasing FIO2. nHFV was delivered using the Infant
Star ventilator. Ventilator setting amplitude was 35cm
H2O; mean airway pressure 7 cm H2O; and
frequency 10Hz.
RESULTS—pCO2
decreased significantly from 8.3 kPa to 7.2 kPa after nHFV was started.
In five patients nHFV was discontinued after a median period of
61/2 hours due to CO2 retention
and high oxygen need, and endotracheal mechanical ventilation was started.
CONCLUSIONS—nHFV can
reduce pCO2 in neonates with moderate respiratory
insufficiency and, therefore, could be used to decrease the need for
endotracheal mechanical ventilation.
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