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Logo of archdischArchives of Disease in ChildhoodVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
Arch Dis Child. Aug 2004; 89(8): 734–735.
PMCID: PMC1720017

Effectiveness of influenza vaccine for the prevention of asthma exacerbations


Background: There is a lack of clinical evidence that annual vaccination against influenza prevents asthma exacerbations in children.

Methods: Retrospective cohort study of 800 children with asthma, where one half did, and the other half did not receive the influenza vaccine. The two groups were compared with respect to clinic visits, emergency department (ED) visits, and hospitalisations for asthma. In multivariable analyses, adjustment was made for baseline asthma severity, prior utilisation of health services, receipt of vaccine in the previous year, and demographic variables.

Results: After adjusting for other variables, the vaccine group had a significantly increased risk of asthma related clinic visits and ED visits (odds ratios 3.4 and 1.9, respectively).

Conclusion: This study failed to provide evidence that the influenza vaccine prevents paediatric asthma exacerbations.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Parkin PC, Taylor CY, Petric M, Schuh S, Goldbach M, Ipp M. Controlled study of respiratory viruses and wheezing. Arch Dis Child. 2002 Sep;87(3):221–222. [PMC free article] [PubMed]
  • Kramarz P, Destefano F, Gargiullo PM, Chen RT, Lieu TA, Davis RL, Mullooly JP, Black SB, Shinefield HR, Bohlke K, et al. Does influenza vaccination prevent asthma exacerbations in children? J Pediatr. 2001 Mar;138(3):306–310. [PubMed]
  • Neuzil KM. Influenza vaccine in children with asthma: why no progress? J Pediatr. 2001 Mar;138(3):301–303. [PubMed]

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