• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of archdischArchives of Disease in ChildhoodVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
Arch Dis Child. Feb 2001; 84(2): 138–141.
PMCID: PMC1718650

Randomised controlled trial of infantile colic treated with chiropractic spinal manipulation

Abstract

AIMS—To investigate the efficacy of chiropractic spinal manipulation in the management of infantile colic.
METHODS—One hundred infants with typical colicky pain were recruited to a randomised, blinded, placebo controlled clinical trial.
RESULTS—Nine infants were excluded because inclusion criteria were not met, and five dropped out, leaving 86 who completed the study. There was no significant effect of chiropractic spinal manipulation. Thirty two of 46 infants in the treatment group (69.9%), and 24of 40 in the control group (60.0%), showed some degree of improvement.
CONCLUSION—Chiropractic spinal manipulation is no more effective than placebo in the treatment of infantile colic. This study emphasises the need for placebo controlled and blinded studies when investigating alternative methods to treat unpredictable conditions such as infantile colic.

Full Text

The Full Text of this article is available as a PDF (104K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • WESSEL MA, COBB JC, JACKSON EB, HARRIS GS, Jr, DETWILER AC. Paroxysmal fussing in infancy, sometimes called colic. Pediatrics. 1954 Nov;14(5):421–435. [PubMed]
  • ILLINGWORTH RS. Three-months' colic. Arch Dis Child. 1954 Jun;29(145):165–174. [PMC free article] [PubMed]
  • St James-Roberts I, Halil T. Infant crying patterns in the first year: normal community and clinical findings. J Child Psychol Psychiatry. 1991 Sep;32(6):951–968. [PubMed]
  • BRAZELTON TB. Crying in infancy. Pediatrics. 1962 Apr;29:579–588. [PubMed]
  • Hunziker UA, Barr RG. Increased carrying reduces infant crying: a randomized controlled trial. Pediatrics. 1986 May;77(5):641–648. [PubMed]
  • Barr RG, Rotman A, Yaremko J, Leduc D, Francoeur TE. The crying of infants with colic: a controlled empirical description. Pediatrics. 1992 Jul;90(1 Pt 1):14–21. [PubMed]
  • James-Roberts IS, Conroy S, Wilsher K. Bases for maternal perceptions of infant crying and colic behaviour. Arch Dis Child. 1996 Nov;75(5):375–384. [PMC free article] [PubMed]
  • Miller AR, Barr RG. Infantile colic. Is it a gut issue? Pediatr Clin North Am. 1991 Dec;38(6):1407–1423. [PubMed]
  • Illingworth RS. Infantile colic revisited. Arch Dis Child. 1985 Oct;60(10):981–985. [PMC free article] [PubMed]
  • Lindberg T. Infantile colic and small intestinal function: a nutritional problem? Acta Paediatr Suppl. 1999 Aug;88(430):58–60. [PubMed]
  • Lothe L, Lindberg T. Cow's milk whey protein elicits symptoms of infantile colic in colicky formula-fed infants: a double-blind crossover study. Pediatrics. 1989 Feb;83(2):262–266. [PubMed]
  • Hill DJ, Hudson IL, Sheffield LJ, Shelton MJ, Menahem S, Hosking CS. A low allergen diet is a significant intervention in infantile colic: results of a community-based study. J Allergy Clin Immunol. 1995 Dec;96(6 Pt 1):886–892. [PubMed]
  • Forsyth BW. Colic and the effect of changing formulas: a double-blind, multiple-crossover study. J Pediatr. 1989 Oct;115(4):521–526. [PubMed]
  • Hill DJ, Hosking CS. Infantile colic and food hypersensitivity. J Pediatr Gastroenterol Nutr. 2000;30 (Suppl):S67–S76. [PubMed]
  • Haouari N, Wood C, Griffiths G, Levene M. The analgesic effect of sucrose in full term infants: a randomised controlled trial. BMJ. 1995 Jun 10;310(6993):1498–1500. [PMC free article] [PubMed]
  • UK paediatric clinical research under threat. Arch Dis Child. 1997 Jan;76(1):1–3. [PMC free article] [PubMed]
  • Grunseit F. Evaluation of the efficacy of dicyclomine hydrochloride ('Merbentyl') syrup in the treatment of infant colic. Curr Med Res Opin. 1977;5(3):258–261. [PubMed]
  • Williams J, Watkins-Jones R. Dicyclomine: worrying symptoms associated with its use in some small babies. Br Med J (Clin Res Ed) 1984 Mar 24;288(6421):901–901. [PMC free article] [PubMed]
  • Metcalf TJ, Irons TG, Sher LD, Young PC. Simethicone in the treatment of infant colic: a randomized, placebo-controlled, multicenter trial. Pediatrics. 1994 Jul;94(1):29–34. [PubMed]
  • Munck LK, Hoffmann H, Nielsen AA. Kiropraktorbehandling af børn i første leveår. Incidens og henvendelsesårsager. Ugeskr Laeger. 1988 Jul 25;150(30):1841–1844. [PubMed]
  • Klougart N, Nilsson N, Jacobsen J. Infantile colic treated by chiropractors: a prospective study of 316 cases. J Manipulative Physiol Ther. 1989 Aug;12(4):281–288. [PubMed]
  • Wiberg JM, Nordsteen J, Nilsson N. The short-term effect of spinal manipulation in the treatment of infantile colic: a randomized controlled clinical trial with a blinded observer. J Manipulative Physiol Ther. 1999 Oct;22(8):517–522. [PubMed]
  • Dihigo SK. New strategies for the treatment of colic: modifying the parent/infant interaction. J Pediatr Health Care. 1998 Sep-Oct;12(5):256–262. [PubMed]
  • Taubman B. Clinical trial of the treatment of colic by modification of parent-infant interaction. Pediatrics. 1984 Dec;74(6):998–1003. [PubMed]
  • Giles LG, Müller R. Chronic spinal pain syndromes: a clinical pilot trial comparing acupuncture, a nonsteroidal anti-inflammatory drug, and spinal manipulation. J Manipulative Physiol Ther. 1999 Jul-Aug;22(6):376–381. [PubMed]
  • Balon J, Aker PD, Crowther ER, Danielson C, Cox PG, O'Shaughnessy D, Walker C, Goldsmith CH, Duku E, Sears MR. A comparison of active and simulated chiropractic manipulation as adjunctive treatment for childhood asthma. N Engl J Med. 1998 Oct 8;339(15):1013–1020. [PubMed]
  • Sawyer CE, Evans RL, Boline PD, Branson R, Spicer A. A feasibility study of chiropractic spinal manipulation versus sham spinal manipulation for chronic otitis media with effusion in children. J Manipulative Physiol Ther. 1999 Jun;22(5):292–298. [PubMed]
  • Ståhlberg MR. Infantile colic: occurrence and risk factors. Eur J Pediatr. 1984 Dec;143(2):108–111. [PubMed]
  • Alvarez M, St James-Roberts I. Infant fussing and crying patterns in the first year in an urban community in Denmark. Acta Paediatr. 1996 Apr;85(4):463–466. [PubMed]
  • Canivet C, Hagander B, Jakobsson I, Lanke J. Infantile colic--less common than previously estimated? Acta Paediatr. 1996 Apr;85(4):454–458. [PubMed]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Group

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Cited in Books
    Cited in Books
    PubMed Central articles cited in books
  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...