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Antimicrob Agents Chemother. May 1990; 34(5): 904–905.
PMCID: PMC171716

Serum sickness-like illness associated with ciprofloxacin.


Serum sickness is a systemic hypersensitivity reaction initially reported in children receiving horse serum. Drugs such as penicillins, cephalosporins, and sulfonamides are now noted to be the most common etiologic agents of serum sickness-like reactions. This case report describes a serum sickness-like reaction temporally related to ciprofloxacin, a previously unreported adverse effect of this drug or any of the other quinolones.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Alanis A, Weinstein AJ. Adverse reactions associated with the use of oral penicillins and cephalosporins. Med Clin North Am. 1983 Jan;67(1):113–129. [PubMed]
  • Choe U, Rothschild BM, Laitman L. Ciprofloxacin-induced vasculitis. N Engl J Med. 1989 Jan 26;320(4):257–258. [PubMed]
  • Davis H, McGoodwin E, Reed TG. Anaphylactoid reactions reported after treatment with ciprofloxacin. Ann Intern Med. 1989 Dec 15;111(12):1041–1043. [PubMed]
  • Hooper DC, Wolfson JS. The fluoroquinolones: pharmacology, clinical uses, and toxicities in humans. Antimicrob Agents Chemother. 1985 Nov;28(5):716–721. [PMC free article] [PubMed]
  • Hootkins R, Fenves AZ, Stephens MK. Acute renal failure secondary to oral ciprofloxacin therapy: a presentation of three cases and a review of the literature. Clin Nephrol. 1989 Aug;32(2):75–78. [PubMed]
  • Lawley TJ, Bielory L, Gascon P, Yancey KB, Young NS, Frank MM. A prospective clinical and immunologic analysis of patients with serum sickness. N Engl J Med. 1984 Nov 29;311(22):1407–1413. [PubMed]
  • Lin RY. Serum sickness syndrome. Am Fam Physician. 1986 Jan;33(1):157–162. [PubMed]
  • Platt R, Dreis MW, Kennedy DL, Kuritsky JN. Serum sickness-like reactions to amoxicillin, cefaclor, cephalexin, and trimethoprim-sulfamethoxazole. J Infect Dis. 1988 Aug;158(2):474–477. [PubMed]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)


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