• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of ajhgLink to Publisher's site
Am J Hum Genet. Sep 1997; 61(3): 497–504.
PMCID: PMC1715964

HLA and mate choice in humans.

Abstract

Evidence from studies in rodents suggests that mate selection is influenced by major-histocompatibility-complex haplotypes, with preferences for dissimilar partners. This study was initiated to determine whether avoidance of a mate with the same HLA haplotype as one's own might be occurring in the Hutterites, a North American reproductive isolate of European ancestry, notable for their large sibships, communal lifestyle, and limited number of five-locus HLA haplotypes (HLA-A, -B, -C, -DR, and -DQ). HLA haplotypes were known for 411 Hutterite couples. The number of couples expected to match for a haplotype was calculated in two ways: first, from population genotype frequencies, with account being taken of the nonrandom mating pattern with respect to colony lineages, and, second, from computer simulations using conservative founder assumptions and the exact genealogy of the 411 couples. We observed fewer matches for HLA haplotypes between spouses than expected (first method, P = .005; second method, P = .020-.067). Among couples who did match for a haplotype, the matched haplotype was inherited from the mother in 29 cases and from the father in 50 cases (P = .018). These results are consistent with the conclusion that Hutterite mate choice is influenced by HLA haplotypes, with an avoidance of spouses with haplotypes that are the same as one's own.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.3M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Beauchamp GK, Yamazaki K, Wysocki CJ, Slotnick BM, Thomas L, Boyse EA. Chemosensory recognition of mouse major histocompatibility types by another species. Proc Natl Acad Sci U S A. 1985 Jun;82(12):4186–4188. [PMC free article] [PubMed]
  • Gilbert AN, Yamazaki K, Beauchamp GK, Thomas L. Olfactory discrimination of mouse strains (Mus musculus) and major histocompatibility types by humans (Homo sapiens). J Comp Psychol. 1986 Sep;100(3):262–265. [PubMed]
  • Kostyu DD, Dawson DV, Elias S, Ober C. Deficit of HLA homozygotes in a Caucasian isolate. Hum Immunol. 1993 Jul;37(3):135–142. [PubMed]
  • Kostyu DD, Ober CL, Dawson DV, Ghanayem M, Elias S, Martin AO. Genetic analysis of HLA in the U.S. Schmiedenleut Hutterites. Am J Hum Genet. 1989 Aug;45(2):261–269. [PMC free article] [PubMed]
  • MANGE AP. GROWTH AND INBREEDING OF A HUMAN ISOLATE. Hum Biol. 1964 May;36:104–133. [PubMed]
  • Martin AO. The founder effect in a human isolate: evolutionary implications. Am J Phys Anthropol. 1970 May;32(3):351–367. [PubMed]
  • Ober C. Current topic: HLA and reproduction: lessons from studies in the Hutterites. Placenta. 1995 Oct;16(7):569–577. [PubMed]
  • Ober C, Elias S, Kostyu DD, Hauck WW. Decreased fecundability in Hutterite couples sharing HLA-DR. Am J Hum Genet. 1992 Jan;50(1):6–14. [PMC free article] [PubMed]
  • Pollack MS, Wysocki CJ, Beauchamp GK, Braun D, Jr, Callaway C, Dupont B. Absence of HLA association or linkage for variations in sensitivity to the odor of androstenone. Immunogenetics. 1982;15(6):579–589. [PubMed]
  • Potts WK, Manning CJ, Wakeland EK. Mating patterns in seminatural populations of mice influenced by MHC genotype. Nature. 1991 Aug 15;352(6336):619–621. [PubMed]
  • Rosenberg LT, Cooperman D, Payne R. HLA and mate selection. Immunogenetics. 1983;17(1):89–93. [PubMed]
  • Wedekind C, Seebeck T, Bettens F, Paepke AJ. MHC-dependent mate preferences in humans. Proc Biol Sci. 1995 Jun 22;260(1359):245–249. [PubMed]
  • Yamaguchi M, Yamazaki K, Beauchamp GK, Bard J, Thomas L, Boyse EA. Distinctive urinary odors governed by the major histocompatibility locus of the mouse. Proc Natl Acad Sci U S A. 1981 Sep;78(9):5817–5820. [PMC free article] [PubMed]
  • Yamazaki K, Beauchamp GK, Kupniewski D, Bard J, Thomas L, Boyse EA. Familial imprinting determines H-2 selective mating preferences. Science. 1988 Jun 3;240(4857):1331–1332. [PubMed]
  • Yamazaki K, Boyse EA, Miké V, Thaler HT, Mathieson BJ, Abbott J, Boyse J, Zayas ZA, Thomas L. Control of mating preferences in mice by genes in the major histocompatibility complex. J Exp Med. 1976 Nov 2;144(5):1324–1335. [PMC free article] [PubMed]
  • Yamazaki K, Yamaguchi M, Baranoski L, Bard J, Boyse EA, Thomas L. Recognition among mice. Evidence from the use of a Y-maze differentially scented by congenic mice of different major histocompatibility types. J Exp Med. 1979 Oct 1;150(4):755–760. [PMC free article] [PubMed]

Articles from American Journal of Human Genetics are provided here courtesy of American Society of Human Genetics

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Cited in Books
    Cited in Books
    PubMed Central articles cited in books
  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...