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Am J Hum Genet. 1988 March; 42(3): 516–520. | PMCID: PMC1715161 |
Glucose 6-phosphate dehydrogenase deficiency and incidence of hematologic malignancy. A M Ferraris, G Broccia, T Meloni, G Forteleoni, and G F Gaetani Division of Hematology, University of Genova, Italy. Abstract We have evaluated the hypothesis of a negative association between glucose 6-phosphate dehydrogenase (G6PD) deficiency and cancer in a cohort of 481 Sardinian males with hematological malignancies. The frequency of G6PD deficiency in the patients was not different from the incidence in a group of 16,219 controls. The same conclusion resulted from the comparison of the frequency of expression of the GdB gene in 23 heterozygous women having a clonal hematologic disease and a control group of 37 healthy heterozygotes. Therefore at present there is no evidence that G6PD deficiency has a protective effect against development of hematologic neoplasms. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (740K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. These references are in PubMed. This may not be the complete list of references from this article. - Arnold A, Cossman J, Bakhshi A, Jaffe ES, Waldmann TA, Korsmeyer SJ. Immunoglobulin-gene rearrangements as unique clonal markers in human lymphoid neoplasms. N Engl J Med. 1983 Dec 29;309(26):1593–1599. [PubMed]
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