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Clin Exp Immunol. 1970 August; 7(2): 133–137. | PMCID: PMC1712843 |
Sub-units of the first complement component in immunologic deficiency syndromes: independence of C1s and C1q R. M. Stroud, K. Nagaki, R. J. Pickering, H. Gewurz, R. A. Good, and M. D. Cooper Abstract Normal concentrations of C1 esterase, C1s, have been found in nineteen individuals with a variety of immunologic deficiency syndromes. C1q levels are markedly low in patients with lymphopenic hypogammaglobulinaemia. The lack of correlation of serum concentrations of C1s with C1q in several patients suggests a separate mode of synthesis or catabolism for these C1 subunits. Furthermore, the extreme C1q deficiency in lymphopenic hypogammaglobulinaemic patients may play a role in their serious prognosis; however the normal C1s concentrations would allow some complement mediated functions. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (564K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. These references are in PubMed. This may not be the complete list of references from this article. - Colten HR, Gordon JM, Borsos T, Rapp HJ. Synthesis of the first component of human complement in vitro. J Exp Med. 1968 Oct 1;128(4):595–604. [PubMed]
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