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Am J Hum Genet. Feb 1997; 60(2): 265–271.
PMCID: PMC1712416

Polymorphisms in drug-metabolizing enzymes: what is their clinical relevance and why do they exist?

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  • Ambrosone CB, Freudenheim JL, Graham S, Marshall JR, Vena JE, Brasure JR, Michalek AM, Laughlin R, Nemoto T, Gillenwater KA, et al. Cigarette smoking, N-acetyltransferase 2 genetic polymorphisms, and breast cancer risk. JAMA. 1996 Nov 13;276(18):1494–1501. [PubMed]
  • Berenbaum M, Feeny P. Toxicity of angular furanocoumarins to swallowtail butterflies: escalation in a coevolutionary arms race? Science. 1981 May 22;212(4497):927–929. [PubMed]
  • Bigelow SW, Collins AC, Nebert DW. Selective mouse breeding for short ethanol sleep time has led to high levels of hepatic aromatic hydrocarbon (Ah) receptor. Biochem Pharmacol. 1989 Oct 15;38(20):3565–3572. [PubMed]
  • Bryant JP, Wieland GD, Reichardt PB, Lewis VE, McCarthy MC. Pinosylvin methyl ether deters snowshoe hare feeding on green alder. Science. 1983 Dec 2;222(4627):1023–1025. [PubMed]
  • Byers JA. Bark beetle conversion of a plant compound to a sex-specific inhibitor of pheromone attraction. Science. 1983 May 6;220(4597):624–626. [PubMed]
  • Cairns J, Overbaugh J, Miller S. The origin of mutants. Nature. 1988 Sep 8;335(6186):142–145. [PubMed]
  • Daly AK, Brockmöller J, Broly F, Eichelbaum M, Evans WE, Gonzalez FJ, Huang JD, Idle JR, Ingelman-Sundberg M, Ishizaki T, et al. Nomenclature for human CYP2D6 alleles. Pharmacogenetics. 1996 Jun;6(3):193–201. [PubMed]
  • Diamond JM. Causes of death before birth. Nature. 1987 Oct 8;329(6139):487–488. [PubMed]
  • di Tomaso E, Beltramo M, Piomelli D. Brain cannabinoids in chocolate. Nature. 1996 Aug 22;382(6593):677–678. [PubMed]
  • Gonzalez FJ, Idle JR. Pharmacogenetic phenotyping and genotyping. Present status and future potential. Clin Pharmacokinet. 1994 Jan;26(1):59–70. [PubMed]
  • Gonzalez FJ, Nebert DW. Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation. Trends Genet. 1990 Jun;6(6):182–186. [PubMed]
  • Hinkle G, Wetterer JK, Schultz TR, Sogin ML. Phylogeny of the attine ant fungi based on analysis of small subunit ribosomal RNA gene sequences. Science. 1994 Dec 9;266(5191):1695–1697. [PubMed]
  • Idle JR, Smith RL. Polymorphisms of oxidation at carbon centers of drugs and their clinical significance. Drug Metab Rev. 1979;9(2):301–317. [PubMed]
  • Lewalter J, Korallus U. Blood protein conjugates and acetylation of aromatic amines. New findings on biological monitoring. Int Arch Occup Environ Health. 1985;56(3):179–196. [PubMed]
  • Ma R, Cohen MB, Berenbaum MR, Schuler MA. Black swallowtail (Papilio polyxenes) alleles encode cytochrome P450s that selectively metabolize linear furanocoumarins. Arch Biochem Biophys. 1994 May 1;310(2):332–340. [PubMed]
  • Metcalf RL, Lampman RL. Evolution of diabroticite rootworm beetle (Chrysomelidae) receptors for Cucurbita blossom volatiles. Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1869–1872. [PMC free article] [PubMed]
  • Meyer UA. Pharmacogenetics: the slow, the rapid, and the ultrarapid. Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):1983–1984. [PMC free article] [PubMed]
  • Nebert DW. Drug metabolism. Growth signal pathways. Nature. 1990 Oct 25;347(6295):709–710. [PubMed]
  • Nebert DW, McKinnon RA. Cytochrome P450: evolution and functional diversity. Prog Liver Dis. 1994;12:63–97. [PubMed]
  • Nebert DW, McKinnon RA, Puga A. Human drug-metabolizing enzyme polymorphisms: effects on risk of toxicity and cancer. DNA Cell Biol. 1996 Apr;15(4):273–280. [PubMed]
  • Nei M, Saitou N. Genetic relationship of human populations and ethnic differences in reaction to drugs and food. Prog Clin Biol Res. 1986;214:21–37. [PubMed]
  • Nelson DR, Koymans L, Kamataki T, Stegeman JJ, Feyereisen R, Waxman DJ, Waterman MR, Gotoh O, Coon MJ, Estabrook RW, et al. P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics. 1996 Feb;6(1):1–42. [PubMed]
  • Parker LS. Bioethics for human geneticists: models for reasoning and methods for teaching. Am J Hum Genet. 1994 Jan;54(1):137–147. [PMC free article] [PubMed]
  • Petranyi G, Ryder NS, Stütz A. Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase. Science. 1984 Jun 15;224(4654):1239–1241. [PubMed]
  • Rotter JI, Diamond JM. What maintains the frequencies of human genetic diseases? Nature. 1987 Sep 24;329(6137):289–290. [PubMed]
  • Sachse C, Brockmöller J, Bauer S, Roots I. Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am J Hum Genet. 1997 Feb;60(2):284–295. [PMC free article] [PubMed]
  • Vatsis KP, Weber WW, Bell DA, Dupret JM, Evans DA, Grant DM, Hein DW, Lin HJ, Meyer UA, Relling MV, et al. Nomenclature for N-acetyltransferases. Pharmacogenetics. 1995 Feb;5(1):1–17. [PubMed]

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