Logo of cdliPermissionsJournals.ASM.orgAEM ArticleJournal InfoAuthorsReviewers
Clin Diagn Lab Immunol. Mar 1995; 2(2): 246–248.
PMCID: PMC170138

Methods for detection of an intestinal secretory immunoglobulin A response to Candida spp. and their preliminary application in human immunodeficiency virus-infected patients with chronic diarrhea.


Six of 11 human immunodeficiency virus (HIV)-infected patients with chronic diarrhea, shedding only Candida spp. in their stools, elicited a Candida-specific secretory immunoglobulin A response. Similar responses were identified in only 1 of 10 HIV-positive patients with chronic diarrhea but without Candida spp. and in none of 10 HIV-negative subjects without diarrhea. Candida spp. may play a role in the etiology of chronic diarrhea associated with HIV infection.

Full Text

The Full Text of this article is available as a PDF (152K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Coogan MM, Sweet SP, Challacombe SJ. Immunoglobulin A (IgA), IgA1, and IgA2 antibodies to Candida albicans in whole and parotid saliva in human immunodeficiency virus infection and AIDS. Infect Immun. 1994 Mar;62(3):892–896. [PMC free article] [PubMed]
  • Cooper TW. Secretory diarrhea and candidal overgrowth: cause and effect? J Infect Dis. 1991 Oct;164(4):823–824. [PubMed]
  • Danna PL, Urban C, Bellin E, Rahal JJ. Role of candida in pathogenesis of antibiotic-associated diarrhoea in elderly inpatients. Lancet. 1991 Mar 2;337(8740):511–514. [PubMed]
  • Gupta TP, Ehrinpreis MN. Candida-associated diarrhea in hospitalized patients. Gastroenterology. 1990 Mar;98(3):780–785. [PubMed]
  • Jayagopal S, Cervia JS. Colitis due to Candida albicans in a patient with AIDS. Clin Infect Dis. 1992 Sep;15(3):555–555. [PubMed]
  • Jiang ZD, Nelson AC, Mathewson JJ, Ericsson CD, DuPont HL. Intestinal secretory immune response to infection with Aeromonas species and Plesiomonas shigelloides among students from the United States in Mexico. J Infect Dis. 1991 Nov;164(5):979–982. [PubMed]
  • Klingspor L, Stitzing G, Johansen K, Murtaza A, Holmberg K. Infantile diarrhoea and malnutrition associated with Candida in a developing community. Mycoses. 1993 Jan-Feb;36(1-2):19–24. [PubMed]
  • Mathewson JJ, Jiang ZD, DuPont HL, Chintu C, Luo N, Zumla A. Intestinal secretory IgA immune response against human immunodeficiency virus among infected patients with acute and chronic diarrhea. J Infect Dis. 1994 Mar;169(3):614–617. [PubMed]
  • Sanderson PJ, Bukhari SS. Candida spp. and Clostridium difficile toxin-negative antibiotic-associated diarrhoea. J Hosp Infect. 1991 Oct;19(2):142–143. [PubMed]
  • Smith PD, Quinn TC, Strober W, Janoff EN, Masur H. NIH conference. Gastrointestinal infections in AIDS. Ann Intern Med. 1992 Jan 1;116(1):63–77. [PubMed]
  • Therizol-Ferly PM, Tagliante-Saracino J, Kone M, Konan A, Ouhon J, Assoumou A, Aka K, Assale G. Diarrhées chroniques et parasitoses chez des adultes suspectés de SIDA en Côte-d'Ivoire. Bull Soc Pathol Exot Filiales. 1989;82(5):690–693. [PubMed]
  • Ullrich R, Heise W, Bergs C, L'age M, Riecken EO, Zeitz M. Gastrointestinal symptoms in patients infected with human immunodeficiency virus: relevance of infective agents isolated from gastrointestinal tract. Gut. 1992 Aug;33(8):1080–1084. [PMC free article] [PubMed]
  • Waldman RH, Cruz JM, Rowe DS. Immunoglobulin levels and antibody to Candida albicans in human cervicovaginal secretions. Clin Exp Immunol. 1972 Mar;10(3):427–434. [PMC free article] [PubMed]
  • Winsor DK, Jr, Mathewson JJ, DuPont HL. Western blot analysis of intestinal secretory immunoglobulin A response to Campylobacter jejuni antigens in patients with naturally acquired Campylobacter enteritis. Gastroenterology. 1986 May;90(5 Pt 1):1217–1222. [PubMed]
  • Winsor DK, Jr, Mathewson JJ, DuPont HL. Comparison of serum and fecal antibody responses of patients with naturally acquired Shigella sonnei infection. J Infect Dis. 1988 Nov;158(5):1108–1112. [PubMed]
  • Wray D, Felix DH, Cumming CG. Alteration of humoral responses to Candida in HIV infection. Br Dent J. 1990 Apr 21;168(8):326–329. [PubMed]

Articles from Clinical and Diagnostic Laboratory Immunology are provided here courtesy of American Society for Microbiology (ASM)


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC


Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...