• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of procbhomepageaboutsubmitalertseditorial board
Proc Biol Sci. May 22, 2004; 271(1543): 1065–1072.
PMCID: PMC1691687

Evolution of the human ABO polymorphism by two complementary selective pressures.

Abstract

The best-known example of terminal-glycan variation is the ABO histo-blood group polymorphism in humans. We model two selective forces acting on histo-blood group antigens that may account for this polymorphism. The first is generated by the invasion of opportunistic bacterial or other pathogens that interact with the epithelial-mucosal surfaces. The bacteria adapt to the microenvironments of common host phenotypes and so create frequency-dependent selection for rarer host alleles. The second is generated by intracellular viruses, and accounts for the observed differentials between the ABO-phenotype frequencies. It is thought that viruses acquire histo-blood group structures as part of their envelope from their previous host. The presence of host antigens on the viral envelope causes differential transmission of the virus between host types owing to the asymmetric action of ABO natural antibodies. Our model simulations show that these two forces acting together can account for the major features of the ABO polymorphism in humans.

Full Text

The Full Text of this article is available as a PDF (397K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Aho K, Pyhälä R, Visakorpi R. ABO associated genetic determinant in H1N1 influenza. Tissue Antigens. 1980 Oct;16(4):310–313. [PubMed]
  • Appelmelk BJ, Shiberu B, Trinks C, Tapsi N, Zheng PY, Verboom T, Maaskant J, Hokke CH, Schiphorst WE, Blanchard D, et al. Phase variation in Helicobacter pylori lipopolysaccharide. Infect Immun. 1998 Jan;66(1):70–76. [PMC free article] [PubMed]
  • Arendrup M, Hansen JE, Clausen H, Nielsen C, Mathiesen LR, Nielsen JO. Antibody to histo-blood group A antigen neutralizes HIV produced by lymphocytes from blood group A donors but not from blood group B or O donors. AIDS. 1991 Apr;5(4):441–444. [PubMed]
  • Balanzino LE, Barra JL, Monferran CG, Cumar FA. Differential interaction of Escherichia coli heat-labile toxin and cholera toxin with pig intestinal brush border glycoproteins depending on their ABH and related blood group antigenic determinants. Infect Immun. 1994 Apr;62(4):1460–1464. [PMC free article] [PubMed]
  • Berger SA, Young NA, Edberg SC. Relationship between infectious diseases and human blood type. Eur J Clin Microbiol Infect Dis. 1989 Aug;8(8):681–689. [PubMed]
  • Björkholm B, Lundin A, Sillén A, Guillemin K, Salama N, Rubio C, Gordon JI, Falk P, Engstrand L. Comparison of genetic divergence and fitness between two subclones of Helicobacter pylori. Infect Immun. 2001 Dec;69(12):7832–7838. [PMC free article] [PubMed]
  • Blackwell C Caroline, Dundas Stephanie, James Valerie S, Mackenzie Doris A C, Braun Jan M, Alkout Abdulhamid M, Todd W T Andrew, Elton Robert A, Weir Donald M. Blood group and susceptibility to disease caused by Escherichia coli O157. J Infect Dis. 2002 Feb 1;185(3):393–396. [PubMed]
  • Fischer C, Jock B, Vogel F. Interplay between humans and infective agents: a population genetic study. Hum Genet. 1998 Apr;102(4):415–422. [PubMed]
  • Gagneux P, Varki A. Evolutionary considerations in relating oligosaccharide diversity to biological function. Glycobiology. 1999 Aug;9(8):747–755. [PubMed]
  • Glass RI, Holmgren J, Haley CE, Khan MR, Svennerholm AM, Stoll BJ, Belayet Hossain KM, Black RE, Yunus M, Barua D. Predisposition for cholera of individuals with O blood group. Possible evolutionary significance. Am J Epidemiol. 1985 Jun;121(6):791–796. [PubMed]
  • Henry SM. Molecular diversity in the biosynthesis of GI tract glycoconjugates. A blood-group-related chart of microorganism receptors. Transfus Clin Biol. 2001 Jun;8(3):226–230. [PubMed]
  • Henry S, Oriol R, Samuelsson B. Lewis histo-blood group system and associated secretory phenotypes. Vox Sang. 1995;69(3):166–182. [PubMed]
  • Hutson Anne M, Atmar Robert L, Marcus Donald M, Estes Mary K. Norwalk virus-like particle hemagglutination by binding to h histo-blood group antigens. J Virol. 2003 Jan;77(1):405–415. [PMC free article] [PubMed]
  • Karlsson KA. Meaning and therapeutic potential of microbial recognition of host glycoconjugates. Mol Microbiol. 1998 Jul;29(1):1–11. [PubMed]
  • Lindesmith Lisa, Moe Christine, Marionneau Severine, Ruvoen Nathalie, Jiang Xi, Lindblad Lauren, Stewart Paul, LePendu Jacques, Baric Ralph. Human susceptibility and resistance to Norwalk virus infection. Nat Med. 2003 May;9(5):548–553. [PubMed]
  • Marionneau S, Cailleau-Thomas A, Rocher J, Le Moullac-Vaidye B, Ruvoën N, Clément M, Le Pendu J. ABH and Lewis histo-blood group antigens, a model for the meaning of oligosaccharide diversity in the face of a changing world. Biochimie. 2001 Jul;83(7):565–573. [PubMed]
  • Moran AP, Prendergast MM, Appelmelk BJ. Molecular mimicry of host structures by bacterial lipopolysaccharides and its contribution to disease. FEMS Immunol Med Microbiol. 1996 Dec 1;16(2):105–115. [PubMed]
  • Mourant AE. Recent advances in the study of associations between infection and genetic markers. FEMS Microbiol Immunol. 1989 Jun;1(6-7):317–319. [PubMed]
  • Naikhin AN, Katorgina LG, Tsaritsyna IM, Kim TN, Reznik VN, Trusov NV, Denisov GM. Pokazateli kollektivnogo immuniteta k grippu v zavisimosti ot gruppi krovi i pola obsleduemogo naseleniia. Vopr Virusol. 1989 Jul-Aug;34(4):419–423. [PubMed]
  • Oriol R, Candelier JJ, Taniguchi S, Balanzino L, Peters L, Niekrasz M, Hammer C, Cooper DK. Major carbohydrate epitopes in tissues of domestic and African wild animals of potential interest for xenotransplantation research. Xenotransplantation. 1999 May;6(2):79–89. [PubMed]
  • Pfennig KS. Evolution of pathogen virulence: the role of variation in host phenotype. Proc Biol Sci. 2001 Apr 7;268(1468):755–760. [PMC free article] [PubMed]
  • Preece Andrew F, Strahan Karen M, Devitt James, Yamamoto Fumi-ichiro, Gustafsson Kenth. Expression of ABO or related antigenic carbohydrates on viral envelopes leads to neutralization in the presence of serum containing specific natural antibodies and complement. Blood. 2002 Apr 1;99(7):2477–2482. [PubMed]
  • Prizont R, Reed WP. Differences in blood group B-specific mucinase activity between virulent and avirulent Shigella flexneri 2a strains. Microb Pathog. 1991 Aug;11(2):129–135. [PubMed]
  • Rad Roland, Gerhard Markus, Lang Roland, Schöniger Martin, Rösch Thomas, Schepp Wolfgang, Becker Ingrid, Wagner Hermann, Prinz Christian. The Helicobacter pylori blood group antigen-binding adhesin facilitates bacterial colonization and augments a nonspecific immune response. J Immunol. 2002 Mar 15;168(6):3033–3041. [PubMed]
  • Ravn V, Dabelsteen E. Tissue distribution of histo-blood group antigens. APMIS. 2000 Jan;108(1):1–28. [PubMed]
  • Sinha AK, Bhattacharya SK, Sen D, Dutta P, Dutta D, Bhattacharya MK, Pal SC. Blood group and shigellosis. J Assoc Physicians India. 1991 Jun;39(6):452–453. [PubMed]
  • SPRINGER GF. Influenza virus vaccine and blood group A-like substances. Transfusion. 1963 May-Jun;3:233–236. [PubMed]
  • Springer GF, Horton RE. Blood group isoantibody stimulation in man by feeding blood group-active bacteria. J Clin Invest. 1969 Jul;48(7):1280–1291. [PMC free article] [PubMed]
  • SPRINGER GF, SCHUSTER R. BLUTGRUPPEN A-AEHNLICHE FORSSMAN-ANTIGENE IN HUEHNEREI GEZUECHTETEN MYXOVIREN: IHRE MOEGLICHE PATHOGENETISCHE BEDEUTUNG IN IMPFSTOFFEN. Klin Wochenschr. 1964 Aug 15;42:821–823. [PubMed]
  • Swerdlow DL, Mintz ED, Rodriguez M, Tejada E, Ocampo C, Espejo L, Barrett TJ, Petzelt J, Bean NH, Seminario L, et al. Severe life-threatening cholera associated with blood group O in Peru: implications for the Latin American epidemic. J Infect Dis. 1994 Aug;170(2):468–472. [PubMed]
  • Takeuchi Y, Porter CD, Strahan KM, Preece AF, Gustafsson K, Cosset FL, Weiss RA, Collins MK. Sensitization of cells and retroviruses to human serum by (alpha 1-3) galactosyltransferase. Nature. 1996 Jan 4;379(6560):85–88. [PubMed]
  • Takeuchi Y, Liong SH, Bieniasz PD, Jäger U, Porter CD, Friedman T, McClure MO, Weiss RA. Sensitization of rhabdo-, lenti-, and spumaviruses to human serum by galactosyl(alpha1-3)galactosylation. J Virol. 1997 Aug;71(8):6174–6178. [PMC free article] [PubMed]
  • Yamamoto F, Clausen H, White T, Marken J, Hakomori S. Molecular genetic basis of the histo-blood group ABO system. Nature. 1990 May 17;345(6272):229–233. [PubMed]
  • Zweibaum A, Bouhou E. Studies of digestive groups. I. The A alloantigen-alloantibody system in rabbits. Transplantation. 1973 Mar;15(3):291–293. [PubMed]
  • Zweibaum A, Oriol R, Feingold N, Dussaulx E, Rousset M, Chevalier G. Studies on canine secretory alloantigens (CSA). Tissue Antigens. 1974;4(2):115–129. [PubMed]

Articles from Proceedings of the Royal Society B: Biological Sciences are provided here courtesy of The Royal Society

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...