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Proc Biol Sci. 2003 Jan 7; 270(1510): 99–103.
PMCID: PMC1691209

Genetic diversity within honeybee colonies prevents severe infections and promotes colony growth.


Multiple mating by social insect queens increases the genetic diversity among colony members, thereby reducing intracolony relatedness and lowering the potential inclusive fitness gains of altruistic workers. Increased genetic diversity may be adaptive, however, by reducing the prevalence of disease within a nest. Honeybees, whose queens have the highest levels of multiple mating among social insects, were investigated to determine whether genetic variation helps to prevent chronic infections. I instrumentally inseminated honeybee queens with semen that was either genetically similar (from one male) or genetically diverse (from multiple males), and then inoculated their colonies with spores of Ascosphaera apis, a fungal pathogen that kills developing brood. I show that genetically diverse colonies had a lower variance in disease prevalence than genetically similar colonies, which suggests that genetic diversity may benefit colonies by preventing severe infections.

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Selected References

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  • Arnqvist G, Nilsson T. The evolution of polyandry: multiple mating and female fitness in insects. Anim Behav. 2000 Aug;60(2):145–164. [PubMed]
  • Baer B, Schmid-Hempel P. Unexpected consequences of polyandry for parasitism and fitness in the bumblebee, Bombus terrestris. Evolution. 2001 Aug;55(8):1639–1643. [PubMed]
  • Baer B, Morgan ED, Schmid-Hempel P. A nonspecific fatty acid within the bumblebee mating plug prevents females from remating. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3926–3928. [PMC free article] [PubMed]
  • Beshers SN, Fewell JH. Models of division of labor in social insects. Annu Rev Entomol. 2001;46:413–440. [PubMed]
  • Cole BJ, Wiernasz DC. The selective advantage of low relatedness . Science. 1999 Aug 6;285(5429):891–893. [PubMed]
  • Duvoisin N, Baer B, Schmid-Hempel P. Sperm transfer and male competition in a bumblebee. Anim Behav. 1999 Oct;58(4):743–749. [PubMed]
  • Hamilton WD. The genetical evolution of social behaviour. II. J Theor Biol. 1964 Jul;7(1):17–52. [PubMed]
  • Hopper KR. Risk-spreading and bet-hedging in insect population biology. Annu Rev Entomol. 1999;44:535–560. [PubMed]
  • Jennions MD, Petrie M. Why do females mate multiply? A review of the genetic benefits. Biol Rev Camb Philos Soc. 2000 Feb;75(1):21–64. [PubMed]
  • Møller AP, Jennions MD. How important are direct fitness benefits of sexual selection? Naturwissenschaften. 2001 Oct;88(10):401–415. [PubMed]
  • Page RE., Jr The evolution of multiple mating behavior by honey bee queens (Apis mellifera L.). Genetics. 1980 Sep;96(1):263–273. [PMC free article] [PubMed]
  • Peters JM, Queller DC, Imperatriz-Fonseca VL, Roubik DW, Strassmann JE. Mate number, kin selection and social conflicts in stingless bees and honeybees. Proc Biol Sci. 1999 Feb 22;266(1417):379–379. [PMC free article]
  • Sauter A, Brown MJ, Baer B, Schmid-Hempel P. Males of social insects can prevent queens from multiple mating. Proc Biol Sci. 2001 Jul 22;268(1475):1449–1454. [PMC free article] [PubMed]
  • Schmid-Hempel P. Ployandry versus polygyny versus parasites. Philos Trans R Soc Lond B Biol Sci. 1999 Feb 28;354(1382):507–515. [PMC free article]

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