• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of procbhomepageaboutsubmitalertseditorial board
Proc Biol Sci. May 22, 2000; 267(1447): 985–990.
PMCID: PMC1690632

Evolution of parasite virulence against qualitative or quantitative host resistance.

Abstract

We analysed the effects of two different modes of host resistance on the evolution of parasite virulence. Hosts can either adopt an all-or-nothing qualitative response (i.e. resistant hosts cannot be infected) or a quantitative form of resistance (i.e. which reduces the within-host growth rate of the parasite). We show that the mode of host resistance greatly affects the evolutionary outcome. Specifically, a qualitative form of resistance reduces parasite virulence, while a quantitative form of resistance generally selects for higher virulence.

Full Text

The Full Text of this article is available as a PDF (197K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Anderson RM, May RM. Coevolution of hosts and parasites. Parasitology. 1982 Oct;85(Pt 2):411–426. [PubMed]
  • Anderson RM, May RM. Immunisation and herd immunity. Lancet. 1990 Mar 17;335(8690):641–645. [PubMed]
  • Bremermann HJ, Pickering J. A game-theoretical model of parasite virulence. J Theor Biol. 1983 Feb 7;100(3):411–426. [PubMed]
  • Ebert D. Experimental evolution of parasites. Science. 1998 Nov 20;282(5393):1432–1435. [PubMed]
  • Fenner F. The Florey lecture, 1983. Biological control, as exemplified by smallpox eradication and myxomatosis. Proc R Soc Lond B Biol Sci. 1983 Jun 22;218(1212):259–285. [PubMed]
  • Frank SA. Dispersal polymorphisms in subdivided populations. J Theor Biol. 1986 Oct 7;122(3):303–309. [PubMed]
  • Frank SA. A kin selection model for the evolution of virulence. Proc Biol Sci. 1992 Dec 22;250(1329):195–197. [PubMed]
  • Frank SA. Kin selection and virulence in the evolution of protocells and parasites. Proc Biol Sci. 1994 Nov 22;258(1352):153–161. [PubMed]
  • Frank SA. Models of parasite virulence. Q Rev Biol. 1996 Mar;71(1):37–78. [PubMed]
  • Gandon S. The curse of the pharaoh hypothesis. Proc Biol Sci. 1998 Aug 22;265(1405):1545–1552. [PMC free article] [PubMed]
  • Mackinnon MJ, Read AF. Selection for high and low virulence in the malaria parasite Plasmodium chabaudi. Proc Biol Sci. 1999 Apr 7;266(1420):741–748. [PMC free article] [PubMed]
  • May RM, Nowak MA. Superinfection, metapopulation dynamics, and the evolution of diversity. J Theor Biol. 1994 Sep 7;170(1):95–114. [PubMed]
  • May RM, Nowak MA. Coinfection and the evolution of parasite virulence. Proc Biol Sci. 1995 Aug 22;261(1361):209–215. [PubMed]
  • Nowak MA, May RM. Superinfection and the evolution of parasite virulence. Proc Biol Sci. 1994 Jan 22;255(1342):81–89. [PubMed]
  • Taylor PD, Frank SA. How to make a kin selection model. J Theor Biol. 1996 May 7;180(1):27–37. [PubMed]
  • van Baalen M. Coevolution of recovery ability and virulence. Proc Biol Sci. 1998 Feb 22;265(1393):317–325. [PMC free article] [PubMed]

Articles from Proceedings of the Royal Society B: Biological Sciences are provided here courtesy of The Royal Society

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...