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Proc Biol Sci. Aug 22, 1998; 265(1405): 1553–1558.
PMCID: PMC1689323

Trade-off associated with selection for increased ability to resist parasitoid attack in Drosophila melanogaster.


Costs of resistance are widely assumed to be important in the evolution of parasite and pathogen defence in animals, but they have been demonstrated experimentally on very few occasions. Endoparasitoids are insects whose larvae develop inside the bodies of other insects where they defend themselves from attack by their hosts' immune systems (especially cellular encapsulation). Working with Drosophila melanogaster and its endoparasitoid Leptopilina boulardi, we selected for increased resistance in four replicate populations of flies. The percentage of flies surviving attack increased from about 0.5% to between 40% and 50% in five generations, revealing substantial additive genetic variation in resistance in the field population from which our culture was established. In comparison with four control lines, flies from selected lines suffered from lower larval survival under conditions of moderate to severe intraspecific competition.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Carton Y, Frey F, Nappi A. Genetic determinism of the cellular immune reaction in Drosophila melanogaster. Heredity (Edinb) 1992 Nov;69(Pt 5):393–399. [PubMed]
  • Dupas S, Brehelin M, Frey F, Carton Y. Immune suppressive virus-like particles in a Drosophila parasitoid: significance of their intraspecific morphological variations. Parasitology. 1996 Sep;113(Pt 3):207–212. [PubMed]
  • Edson KM, Vinson SB, Stoltz DB, Summers MD. Virus in a parasitoid wasp: suppression of the cellular immune response in the parasitoid's host. Science. 1981 Feb 6;211(4482):582–583. [PubMed]
  • Kraaijeveld AR, Godfray HC. Trade-off between parasitoid resistance and larval competitive ability in Drosophila melanogaster. Nature. 1997 Sep 18;389(6648):278–280. [PubMed]
  • Nappi AJ, Vass E, Frey F, Carton Y. Superoxide anion generation in Drosophila during melanotic encapsulation of parasites. Eur J Cell Biol. 1995 Dec;68(4):450–456. [PubMed]
  • Rizki RM, Rizki TM. Parasitoid virus-like particles destroy Drosophila cellular immunity. Proc Natl Acad Sci U S A. 1990 Nov;87(21):8388–8392. [PMC free article] [PubMed]
  • Santos M, Fowler K, Partridge L. On the use of tester stocks to predict the competitive ability of genotypes. Heredity (Edinb) 1992 Dec;69(Pt 6):489–495. [PubMed]
  • Strand MR. Microplitis demolitor polydnavirus infects and expresses in specific morphotypes of Pseudoplusia includens haemocytes. J Gen Virol. 1994 Nov;75(Pt 11):3007–3020. [PubMed]
  • Strand MR, Pech LL. Immunological basis for compatibility in parasitoid-host relationships. Annu Rev Entomol. 1995;40:31–56. [PubMed]

Articles from Proceedings of the Royal Society B: Biological Sciences are provided here courtesy of The Royal Society


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