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Journal List > Br Med J > v.2(6033); Aug 21, 1976

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Br Med J. 1976 August 21; 2(6033): 453–455.
PMCID: PMC1687593
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Effect of atenolol on ventilatory and cardiac function in asthma.
J S Vilsvik and J Schaanning
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Abstract
The effects on ventilatory and cardiac function of atenolol, a new cardioselective beta-adrenoceptor blocking agent, were compared with those of practolol in a double-blind trial in 12 patients with asthma. Both drugs impaired ventilatory function--atenolol insignificantly and practolol significantly. Atenolol was if anything more cardioselective than practolol. Neither drug interfered significantly with the bronchodilator response to inhaled isoprenaline. Atenolol is suitable for use in patients for whom practolol would formerly have been chosen because of its cardioselectivity.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
  • Macdonald AG, McNeill RS. A comparison of the effect on airway resistance of a new beta blocking drug, ICI.50,172 and propranolol. Br J Anaesth. 1968 Jul;40(7):508–510. [PubMed]
  • Powles R, Shinebourne E, Hamer J. Selective cardiac sympathetic blockade as an adjunct to bronchodilator therapy. Thorax. 1969 Sep;24(5):616–618. [PubMed]
  • Schaanning J, Vilsvik JS. Beta1-blocker (practolol) and exercise in patients with chronic obstructive lung disease. Acta Med Scand. 1976;199(1-2):61–64. [PubMed]
  • Conway FJ, Fitzgerald JD, McAinsh J, Rowlands DJ, Simpson WT. Human pharmacokinetic and pharmacodynamic studies on the atenolo (ICI 66,082), a new cardioselective beta-adrenoceptor blocking drug. Br J Clin Pharmacol. 1976 Apr;3(2):267–272. [PubMed]
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  • Formgren H. Practolol in the treatment of tachyarrhythmias in patients with bronchial asthma. Am Heart J. 1972 Nov;84(5):710–712. [PubMed]
  • Jones RS. Significance of effect of beta blockade on ventilatory function in normal and asthmatic subjects. Thorax. 1972 Sep;27(5):572–576. [PubMed]
  • Marlin GE, Kumana CR, Kaye CM, Smith DM, Turner P. An investigation into the cardiac and pulmonary beta-adrenoceptor blocking activity of ICI 66,082 in man. Br J Clin Pharmacol. 1975 Apr;2(2):151–157. [PubMed]
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