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Am J Hum Genet. May 1982; 34(3): 395–401.
PMCID: PMC1685324

Evidence for a major dominance component in the variation of serum pepsinogen I levels


We report here a variance component analysis of the distribution of serum pepsinogen I levels in normal individuals, using a maximum-likelihood method on entire pedigrees. The results indicate a broad heritability of 91%, with some 74% being attributed to a dominance component. This is consistent with the hypothesis that the pepsinogen I level in normals is principally determined by the action of major genes, as also seems to be the case for duodenal ulcer patients and families.

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Selected References

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  • Rotter JI, Sones JQ, Samloff IM, Richardson CT, Gursky JM, Walsh JH, Rimoin DL. Duodenal-ulcer disease associated with elevated serum pepsinogen I: an inherited autosomal dominant disorder. N Engl J Med. 1979 Jan 11;300(2):63–66. [PubMed]
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