• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of ajhgLink to Publisher's site
Am J Hum Genet. Aug 1990; 47(2): 247–254.
PMCID: PMC1683708

A multivariate method for detecting genetic linkage, with application to a pedigree with an adverse lipoprotein phenotype.

Abstract

The robust or model-free method for detecting linkage developed by Haseman and Elston for data from sib pairs is extended to incorporate observations of multiple traits on each individual. A method is proposed that estimates the linear function that results in the strongest correlation between the squared pair differences in the trait measurements and identity by descent at a marker locus. The method is illustrated by the study of apolipoprotein and cholesterol levels in individuals from a large family that had many members diagnosed with coronary heart disease.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.3M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Albers JJ, Utermann G. Genetic control of lecithin-cholesterol acyltransferase (LCAT): measurement of LCAT mass in a large kindred with LCAT deficiency. Am J Hum Genet. 1981 Sep;33(5):702–708. [PMC free article] [PubMed]
  • Amos CI, Elston RC, Srinivasan SR, Wilson AF, Cresanta JL, Ward LJ, Berenson GS. Linkage and segregation analyses of apolipoproteins A1 and B, and lipoprotein cholesterol levels in a large pedigree with excess coronary heart disease: the Bogalusa Heart Study. Genet Epidemiol. 1987;4(2):115–128. [PubMed]
  • Amos CI, Elston RC, Wilson AF, Bailey-Wilson JE. A more powerful robust sib-pair test of linkage for quantitative traits. Genet Epidemiol. 1989;6(3):435–449. [PubMed]
  • Amos CI, Wilson AF, Rosenbaum PA, Srinivasan SR, Webber LS, Elston RC, Berenson GS. An approach to the multivariate analysis of high-density-lipoprotein cholesterol in a large kindred: the Bogalusa Heart Study. Genet Epidemiol. 1986;3(4):255–267. [PubMed]
  • Bailey-Wilson JE, Elston RC, Wilson AF, Amos CI. A comparison of some sib-pair linkage methods and multiple locus extensions. Prog Clin Biol Res. 1989;329:129–134. [PubMed]
  • Bonney GE. On the statistical determination of major gene mechanisms in continuous human traits: regressive models. Am J Med Genet. 1984 Aug;18(4):731–749. [PubMed]
  • Bonney GE, Lathrop GM, Lalouel JM. Combined linkage and segregation analysis using regressive models. Am J Hum Genet. 1988 Jul;43(1):29–37. [PMC free article] [PubMed]
  • Elston RC, Namboodiri KK, Glueck CJ, Fallat R, Tsang R, Leuba V. Study of the genetic transmission of hypercholesterolemia and hypertriglyceridemia in a 195 member kindred. Ann Hum Genet. 1975 Jul;39(1):67–87. [PubMed]
  • Faust RA, Cheung MC, Albers JJ. Secretion of cholesteryl ester transfer protein-lipoprotein complexes by human HepG2 hepatocytes. Atherosclerosis. 1989 May;77(1):77–82. [PubMed]
  • Goldin LR, Elston RC, Graham JB, Miller CH. Genetic analysis of von Willebrand's disease in two large pedigrees: a multivariate approach. Am J Med Genet. 1980;6(4):279–293. [PubMed]
  • Haseman JK, Elston RC. The investigation of linkage between a quantitative trait and a marker locus. Behav Genet. 1972 Mar;2(1):3–19. [PubMed]
  • Hill AP. Quantitative linkage: a statistical procedure for its detection and estimation. Ann Hum Genet. 1975 May;38(4):439–449. [PubMed]
  • Jayakar SD. On the detection and estimation of linkage between a locus influencing a quantitative character and a marker locus. Biometrics. 1970 Sep;26(3):451–464. [PubMed]
  • Kidd KK, Kidd JR, Castiglione CM, Pakstis AJ, Sparkes RS. Progress toward resolving the possible linkage of multiple endocrine neoplasia type 2A to haptoglobin and group-specific loci: use of restriction fragment length polymorphisms extends exclusion region. Genet Epidemiol. 1986;3(3):195–200. [PubMed]
  • Lange K, Boehnke M. Extensions to pedigree analysis. IV. Covariance components models for multivariate traits. Am J Med Genet. 1983 Mar;14(3):513–524. [PubMed]
  • LOWRY DC, SHULTZ FT. Testing association of metric traits and marker genes. Ann Hum Genet. 1959 Apr;23(2):83–90. [PubMed]
  • Lusis AJ, Zollman S, Sparkes RS, Klisak I, Mohandas T, Drayna D, Lawn RM. Assignment of the human gene for cholesteryl ester transfer protein to chromosome 16q12-16q21. Genomics. 1987 Nov;1(3):232–235. [PubMed]
  • Namboodiri KK, Elston RC, Glueck CJ, Fallat R, Buncher CR, Tsang R. Bivariate analyses of cholesterol and triglyceride levels in families in which probands have type IIb lipoprotein phenotype. Am J Hum Genet. 1975 Jul;27(4):454–471. [PMC free article] [PubMed]
  • Risch N. Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs. Am J Hum Genet. 1990 Feb;46(2):242–253. [PMC free article] [PubMed]
  • Rosenbaum PA, Amos CI, Shear CL, Elston RC, Sellers TA, Srinivasan SR, Berenson GS. Description of a large pedigree with an adverse lipoprotein cholesterol phenotype: the Bogalusa Heart Study. Genet Epidemiol. 1986;3(4):241–253. [PubMed]
  • Teisberg P, Gjone E, Olaisen B. Genetics of LCAT (lecithin: cholesterol acyltransferase) deficiency. Ann Hum Genet. 1975 Jan;38(3):327–331. [PubMed]
  • Zlotnik LH, Elston RC, Namboodiri KK. Pedigree discriminant analysis: a method to identify monogenic segregation. Am J Med Genet. 1983 Jun;15(2):307–313. [PubMed]

Articles from American Journal of Human Genetics are provided here courtesy of American Society of Human Genetics

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...