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Mol Syst Biol. 2006; 2: 2006.0017.
Published online May 2, 2006. doi:  10.1038/msb4100059
PMCID: PMC1681491

Core transcriptional regulatory circuitry in human hepatocytes

Abstract

We mapped the transcriptional regulatory circuitry for six master regulators in human hepatocytes using chromatin immunoprecipitation and high-resolution promoter microarrays. The results show that these regulators form a highly interconnected core circuitry, and reveal the local regulatory network motifs created by regulator–gene interactions. Autoregulation was a prominent theme among these regulators. We found that hepatocyte master regulators tend to bind promoter regions combinatorially and that the number of transcription factors bound to a promoter corresponds with observed gene expression. Our studies reveal portions of the core circuitry of human hepatocytes.

Keywords: autoregulation, hepatocyte, transcriptional regulation, regulatory hierarchy, chromatin immunoprecipitation

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