Logo of bmjLink to Publisher's site
BMJ. 1993 Oct 16; 307(6910): 988–990.
PMCID: PMC1679213

Adverse reactions to influenza vaccine in elderly people: randomised double blind placebo controlled trial.

Abstract

OBJECTIVE--To assess the frequency and type of side effects after influenza vaccination in elderly people. DESIGN--Randomised double blind placebo controlled study. SETTING--15 general practices in the southern Netherlands. SUBJECTS--1806 patients aged 60 or older, of whom 904 received influenza vaccine and 902 placebo. MAIN OUTCOME MEASURES--Adverse reactions reported on postal questionnaire completed four weeks after vaccination. RESULTS--210 (23%) patients given vaccine reported one or more adverse reactions compared with 127 (14%) given placebo. The frequency of local adverse reactions were 17.5% in the vaccine group and 7.3% in the placebo group (p < 0.001). There was no difference in systemic adverse reactions (11% v 9.4%; p = 0.34). In general, men reported fewer side effects than women. CONCLUSION--Only local side effects were more common in vaccinated patients and all side effects were mild.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (652K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Helliwell BE, Drummond MF. The costs and benefits of preventing influenza in Ontario's elderly. Can J Public Health. 1988 May-Jun;79(3):175–180. [PubMed]
  • Nichol KL, Lofgren RP, Gapinski J. Influenza vaccination. Knowledge, attitudes, and behavior among high-risk outpatients. Arch Intern Med. 1992 Jan;152(1):106–110. [PubMed]
  • Eraker SA, Kirscht JP, Becker MH. Understanding and improving patient compliance. Ann Intern Med. 1984 Feb;100(2):258–268. [PubMed]
  • Ganguly R, Schler S, Vargas L, Cameron D, Chmel H, Benhke RH. Reasons for nonimmunization against influenza in the aged. J Am Geriatr Soc. 1989 Apr;37(4):387–387. [PubMed]
  • Mostow SR, Schoenbaum SC, Dowdle WR, Coleman MT, Kaye HS. Studies with inactivated influenza vaccines purified by zonal centrifugation. 1. Adverse reactions and serological responses. Bull World Health Organ. 1969;41(3):525–530. [PMC free article] [PubMed]
  • Ruben FL, Jackson GG. A new subunit influenza vaccine: acceptability compared with standard vaccines and effect of dose on antigenicity. J Infect Dis. 1972 Jun;125(6):656–664. [PubMed]
  • Mostow SR, Eickhoff TC, Chelgren GA, Retailliau HF, Castle M. Studies of inactivated influenza virus vaccines in hospital employees: reactogenicity and absenteeism. J Infect Dis. 1977 Dec;136 (Suppl):S533–S538. [PubMed]
  • Margolis KL, Nichol KL, Poland GA, Pluhar RE. Frequency of adverse reactions to influenza vaccine in the elderly. A randomized, placebo-controlled trial. JAMA. 1990 Sep 5;264(9):1139–1141. [PubMed]
  • Margolis KL, Poland GA, Nichol KL, MacPherson DS, Meyer JD, Korn JE, Lofgren RP. Frequency of adverse reactions after influenza vaccination. Am J Med. 1990 Jan;88(1):27–30. [PubMed]
  • Scheifele DW, Bjornson G, Johnston J. Evaluation of adverse events after influenza vaccination in hospital personnel. CMAJ. 1990 Jan 15;142(2):127–130. [PMC free article] [PubMed]
  • Barker WH, Mullooly JP. Impact of epidemic type A influenza in a defined adult population. Am J Epidemiol. 1980 Dec;112(6):798–811. [PubMed]
  • Barker WH, Mullooly JP. Pneumonia and influenza deaths during epidemics: implications for prevention. Arch Intern Med. 1982 Jan;142(1):85–89. [PubMed]
  • Sprenger MJ, Desmyter J, Masurel N. Minderheidsstandpunt over influenzavaccinatie bij ouderen. Ned Tijdschr Geneeskd. 1991 Nov 23;135(47):2208–2210. [PubMed]
  • La Montagne JR, Noble GR, Quinnan GV, Curlin GT, Blackwelder WC, Smith JI, Ennis FA, Bozeman FM. Summary of clinical trials of inactivated influenza vaccine - 1978. Rev Infect Dis. 1983 Jul-Aug;5(4):723–736. [PubMed]
  • Masurel N, Laufer J. A one-year study of trivalent influenza vaccines in primed and unprimed volunteers: immunogenicity, clinical reactions and protection. J Hyg (Lond) 1984 Jun;92(3):263–276. [PMC free article] [PubMed]
  • Gomm PJ, Osselton MD, Broster CG, Johnson NM, Upton K. Study into the ability of patients with impaired lung function to use breath alcohol testing devices. Med Sci Law. 1991 Jul;31(3):221–225. [PubMed]

Articles from BMJ : British Medical Journal are provided here courtesy of BMJ Group

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Cited in Books
    Cited in Books
    PubMed Central articles cited in books
  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...