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Br Med J. Nov 29, 1975; 4(5995): 496–498.
PMCID: PMC1675654

Histological evidence of carcinoma in a hepatic tumour associated with oral contraceptives.

Abstract

A primary hepatic tumour occurred in a 21-year-old woman who had been taking oral contraceptives for two years; she was treated by partial hepatectomy. Part of the neoplasm showed features suggestive of focal nodular hyperplasia, while the remainder had the histological characteristics of a well-differentiated hepatocellular carcinoma. This is the first report of malignant transformation of a tumour in a patient taking oral contraceptives.

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Selected References

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  • Knapp WA, Ruebner BH. Letter: Hepatomas and oral contraceptives. Lancet. 1974 Feb 16;1(7851):270–271. [PubMed]
  • Kelso DR. Letter: Benign hepatomas and oral contraceptives. Lancet. 1974 Feb 23;1(7852):315–316. [PubMed]
  • O'Sullivan JP, Wilding RP. Liver hamartomas in patients on oral contraceptives. Br Med J. 1974 Jul 6;3(5922):7–10. [PMC free article] [PubMed]
  • Tountas C, Paraskevas G, Deligeorgi H. Letter: Benign hepatoma and oral contraceptives. Lancet. 1974 Jun 29;1(7870):1351–1352. [PubMed]
  • Mays ET, Christopherson WM, Barrows GH. Focal nodular hyperplasia of the liver. Possible relationship to oral contraceptives. Am J Clin Pathol. 1974 Jun;61(6):735–746. [PubMed]
  • Berg JW, Ketalaar RJ, Rose EF, Vernon RG. Letter: Hepatomas and oral contraceptives. Lancet. 1974 Aug 10;2(7876):349–350. [PubMed]
  • Mdel DG, Fox JA, Jones RW. Letter: Multiple hepatic adenomas associated with an oral contraceptive. Lancet. 1975 Apr 12;1(7911):865–865. [PubMed]
  • YANOFF M, RAWSON AJ. PELIOSIS HEPATIS. AN ANATOMIC STUDY WITH DEMONSTRATION OF TWO VARIETIES. Arch Pathol. 1964 Feb;77:159–165. [PubMed]

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