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Journal List > Br Med J > v.4(5990); Oct 25, 1975

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Br Med J. 1975 October 25; 4(5990): 203–204.
PMCID: PMC1674965
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Observations on the systemic effect of topical clobetasol propionate (Dermovate).
J A Carruthers, P J August, and R C Staughton
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Abstract
Topical application of clobetasol propionate in a strength of 0-05% in cream or ointment (Dermovate) suppressed the hypothalamic-pituitary-adrenal axis in both normal people and patients with diseased skin. In normal people the 9 am serum cortisol level was suppressed when between 45 and 90 g was applied weekly. Insulin stress test results in patients with diseased skin showed an abnormally small response after long-term application of similar amounts. We conclude that long-term administration should be restricted to less than 50 g a week.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
  • Sparkes CG, Wilson L. The clinical evaluation of a new topical corticosteroid, clobetasol propionate. An international controlled trial. Br J Dermatol. 1974 Feb;90(2):197–203. [PubMed]
  • Staughton RC, August PJ. Cushing's syndrome and pituitary-adrenal suppression due to clobetasol propionate. Br Med J. 1975 May 24;2(5968):419–421. [PubMed]
  • Tan RS. Pustular psoriasis with adrenal suppression following topical corticosteroids. Proc R Soc Med. 1974 Aug;67(8):719–720. [PubMed]
  • Feiwel M, Kelly WF. Letter: Adrenal unresponsiveness associated with clobetasol propionate. Lancet. 1974 Jul 13;2(7872):112–113. [PubMed]
  • Ortega E, Burdick KH, Segre EJ. Letter: Adrenal suppression by clobetasol propionate. Lancet. 1975 May 24;1(7917):1200. [PubMed]
  • Boxley JD, Dawber RP, Summerly R. Generalized pustular psoriasis on withdrawal of clobetasol propionate ointment. Br Med J. 1975 May 3;2(5965):255–256. [PubMed]
  • Baker H, Ryan TJ. Generalized pustular psoriasis. A clinical and epidemiological study of 104 cases. Br J Dermatol. 1968 Dec;80(12):771–793. [PubMed]
  • Murphy BE. Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. J Clin Endocrinol Metab. 1967 Jul;27(7):973–990. [PubMed]
  • LANDON J, WYNN V, JAMES VH. THE ADRENOCORTICAL RESPONSE TO INSULIN-INDUCED HYPOGLYCAEMIA. J Endocrinol. 1963 Nov;27:183–192. [PubMed]
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