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Journal List > Br Med J > v.3(5980); Aug 16, 1975

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Br Med J. 1975 August 16; 3(5980): 413–414.
PMCID: PMC1673852
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Value of prednisone in combination chemotherapy of stage IV Hodgkin's disease. Report from the British National Lymphoma Investigation.
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Abstract
A combination of mustine, vincristine (Oncovin), procarbazine, and prednisione (MOPP) and the same combination without prednisone (MOP) were compared in the treatment of stage IV Hodgkin's disease in a prospective randomized trial. The complete remission rates were 80% with MOPP and 44% with MOP; the difference was highly significant. Prednisone seems to be an important component of the MOPP combination in the management of stage IV Hodgkin's disease.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
  • Devita VT, Jr, Serpick AA, Carbone PP. Combination chemotherapy in the treatment of advanced Hodgkin's disease. Ann Intern Med. 1970 Dec;73(6):881–895. [PubMed]
  • RANNEY HM, GELLHORN A. The effect of massive prednisone and prednisolone therapy on acute leukemia and malignant lymphomas. Am J Med. 1957 Mar;22(3):405–413. [PubMed]
  • JELLIFFE AM, NABARRO JD. Corticosteroids in the treatment of the reticuloses. Br J Radiol. 1961 Sep;34:577–580. [PubMed]
  • MOLONEY WC, DAVIS S, HIEBER RD. The use of steroid hormones in the management of hematologic disorders. GP. 1961 Jul;24:101–106. [PubMed]
  • ROSENBERG SA, DIAMOND HD, JASLOWITZ B, CRAVER LF. Lymphosarcoma: a review of 1269 cases. Medicine (Baltimore). 1961 Feb;40:31–84. [PubMed]
  • Hall TC, Choi OS, Abadi A, Krant MJ. High-dose corticoid therapy in Hodgkin's disease and other lymphomas. Ann Intern Med. 1967 Jun;66(6):1144–1153. [PubMed]
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