• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of bmjLink to Publisher's site
BMJ. Jun 1, 1991; 302(6788): 1302–1305.
PMCID: PMC1670011

Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.

Abstract

OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (927K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Perez-Perez GI, Taylor DN, Bodhidatta L, Wongsrichanalai J, Baze WB, Dunn BE, Echeverria PD, Blaser MJ. Seroprevalence of Helicobacter pylori infections in Thailand. J Infect Dis. 1990 Jun;161(6):1237–1241. [PubMed]
  • Fox JG, Correa P, Taylor NS, Zavala D, Fontham E, Janney F, Rodriguez E, Hunter F, Diavolitsis S. Campylobacter pylori-associated gastritis and immune response in a population at increased risk of gastric carcinoma. Am J Gastroenterol. 1989 Jul;84(7):775–781. [PubMed]
  • Forman D, Sitas F, Newell DG, Stacey AR, Boreham J, Peto R, Campbell TC, Li J, Chen J. Geographic association of Helicobacter pylori antibody prevalence and gastric cancer mortality in rural China. Int J Cancer. 1990 Oct 15;46(4):608–611. [PubMed]
  • Robey-Cafferty SS, Ro JY, Cleary KR. The prevalence of Campylobacter pylori in gastric biopsies from cancer patients. Mod Pathol. 1989 Sep;2(5):473–476. [PubMed]
  • Feng YY, Wang Y. Campylobacter pylori in patients with gastritis, peptic ulcer, and carcinoma of the stomach in Lanzhou, China. Lancet. 1988 May 7;1(8593):1055–1055. [PubMed]
  • Jaskiewicz K, Louwrens HD, Woodroof CW, van Wyk MJ, Price SK. The association of Campylobacter pylori with mucosal pathological changes in a population at risk for gastric cancer. S Afr Med J. 1989 May 6;75(9):417–419. [PubMed]
  • Wald N, Idle M, Boreham J, Bailey A. Low serum-vitamin-A and subsequent risk of cancer. Preliminary results of a prospective study. Lancet. 1980 Oct 18;2(8199):813–815. [PubMed]
  • Kwa HG, Cleton F, Wang DY, Bulbrook RD, Bulstrode JC, Hayward JL, Millis RR, Cuzick J. A prospective study of plasma prolactin levels and subsequent risk of breast cancer. Int J Cancer. 1981 Dec;28(6):673–676. [PubMed]
  • Yang PC, Davis S. Epidemiological characteristics of adenocarcinoma of the gastric cardia and distal stomach in the United States, 1973-1982. Int J Epidemiol. 1988 Jun;17(2):293–297. [PubMed]
  • Howson CP, Hiyama T, Wynder EL. The decline in gastric cancer: epidemiology of an unplanned triumph. Epidemiol Rev. 1986;8:1–27. [PubMed]
  • Barker DJ, Coggon D, Osmond C, Wickham C. Poor housing in childhood and high rates of stomach cancer in England and Wales. Br J Cancer. 1990 Apr;61(4):575–578. [PMC free article] [PubMed]
  • Siurala M, Sipponen P, Kekki M. Campylobacter pylori in a sample of Finnish population: relations to morphology and functions of the gastric mucosa. Gut. 1988 Jul;29(7):909–915. [PMC free article] [PubMed]
  • Sitas F, Forman D, Yarnell JW, Burr ML, Elwood PC, Pedley S, Marks KJ. Helicobacter pylori infection rates in relation to age and social class in a population of Welsh men. Gut. 1991 Jan;32(1):25–28. [PMC free article] [PubMed]
  • Marshall BJ. Campylobacter pylori: its link to gastritis and peptic ulcer disease. Rev Infect Dis. 1990 Jan-Feb;12 (Suppl 1):S87–S93. [PubMed]

Articles from BMJ : British Medical Journal are provided here courtesy of BMJ Group

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...