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Br J Pharmacol. 1976 Apr; 56(4): 399–402.
PMCID: PMC1666891

Lithium orotate, carbonate and chloride: pharmacokinetics, polyuria in rats.


1 The pharmacokinetics of the lithium ion administered as lithium orotate were studied in rats. Parallel studies were carried out with lithium carbonate and lithium chloride. 2 No differences in the uptake, distribution and excretion of the lithium ion were observed between lithium orotate, lithium carbonate and lithium chloride after single intraperitoneal, subcutaneous or intragastric injections (0.5-1.0 mEq lithium/kg) or after administration of the lithium salts for 20 days in the food. 3 The findings oppose the notion that the pharmacokinetics of the lithium ion given as lithium orotate differ from lithium chloride or lithium carbonate. 4 Polyuria and polydipsia developed more slowly in rats given lithium orotate than in those given lithium carbonate or lithium chloride, perhaps due to an effect of the orotate anion.

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Selected References

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  • Birch NJ, Hullin RP. The distribution and binding of lithium following its long-term administration. Life Sci II. 1972 Nov 22;11(22):1095–1099. [PubMed]
  • Ebadi MS, Simmons VJ, Hendrickson MJ, Lacy PS. Pharmacokinetics of lithium and its regional distribution in rat brain. Eur J Pharmacol. 1974 Aug;27(3):324–329. [PubMed]
  • Morrison JM, Jr, Pritchard HD, Braude MC, D'Aguanno W. Plasma and brain lithium levels after lithium carbonate and lithium chloride administration by different routes in rats. Proc Soc Exp Biol Med. 1971 Jul;137(3):889–892. [PubMed]
  • Nieper A. Recalcification of bone metastases by calcium diorotate. Agressologie. 1970;11(6):495–500. [PubMed]
  • Nieper HA. The clinical applications of lithium orotate. A two years study. Agressologie. 1973;14(6):407–411. [PubMed]

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