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BMJ. Apr 14, 1990; 300(6730): 967–972.
PMCID: PMC1662695

The Kenyan Luo migration study: observations on the initiation of a rise in blood pressure.

Abstract

OBJECTIVE--To demonstrate the magnitude, timing, and cause of changes in blood pressure that occur in migrants from a low blood pressure population on moving to an urban area. DESIGN--A controlled longitudinal observational study of migrants as soon after migration as possible and follow up at three, six, 12, 18, and 24 months after migration. A cohort of controls living in a rural area who were matched for age, sex, and locality were also observed at the same periods. SETTING--35 Villages on the northern shores of Lake Victoria in western Kenya and Nairobi. PARTICIPANTS--325 Members of the Luo tribe aged 15 to 34 years who had migrated to Nairobi and 267 controls living in villages. The numbers of both groups reduced during follow up such that only 63 migrants and 143 controls were followed up for two years. MAIN OUTCOME MEASURES--A medical questionnaire and three 24 hour diet histories were completed by migrants and controls. Height, weight, pulse, and blood pressure were measured. Three 12 hour overnight urine samples were collected from all participants and analysed for sodium, potassium, and creatinine concentrations. RESULTS--The mean systolic blood pressure of migrants was significantly higher than that of controls throughout the study, and the distribution of blood pressure was shifted to the right compared with controls. The mean diastolic blood pressure of the two groups diverged over time. Blood pressure differences were not due to selective migration. The migrants' mean urinary sodium:potassium ratio was higher than that of controls (p less than 0.001) throughout, and weight and pulse rate were also higher among migrants, although differences diminished with time. CONCLUSIONS--Urinary sodium:potassium ratio, pulse rate, and weight are important predictors of increased blood pressure among migrants from a low blood pressure community and may also be implicated in the initiation of essential hypertension.

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Selected References

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  • Kannel WB. Some lessons in cardiovascular epidemiology from Framingham. Am J Cardiol. 1976 Feb;37(2):269–282. [PubMed]
  • Kannel WB, Neaton JD, Wentworth D, Thomas HE, Stamler J, Hulley SB, Kjelsberg MO. Overall and coronary heart disease mortality rates in relation to major risk factors in 325,348 men screened for the MRFIT. Multiple Risk Factor Intervention Trial. Am Heart J. 1986 Oct;112(4):825–836. [PubMed]
  • Sinnett PF, Whyte HM. Epidemiological studies in a total highland population, Tukisenta, New Guinea. Cardiovascular disease and relevant clinical, electrocardiographic, radiological and biochemical findings. J Chronic Dis. 1973 May;26(5):265–290. [PubMed]
  • Truswell AS, Kennelly BM, Hansen JD, Lee RB. Blood pressures of Kung bushmen in Northern Botswana. Am Heart J. 1972 Jul;84(1):5–12. [PubMed]
  • Shaper AG, Wright DH, Kyobe J. Blood pressure and body build in three nomadic tribes of northern Kenya. East Afr Med J. 1969 May;46(5):273–281. [PubMed]
  • Shaper AG, Leonard PJ, Jones KW, Jones M. Environmental effects on the body build, blood pressure and blood chemistry of nomadic warriors serving in the army in Kenya. East Afr Med J. 1969 May;46(5):282–289. [PubMed]
  • Sever PS, Gordon D, Peart WS, Beighton P. Blood-pressure and its correlates in urban and tribal Africa. Lancet. 1980 Jul 12;2(8185):60–64. [PubMed]
  • CRUZ-COKE R, ETCHEVERRY R, NAGEL R. INFLUENCE OF MIGRATION ON BLOOD-PRESSURE OF EASTER ISLANDERS. Lancet. 1964 Mar 28;1(7335):697–699. [PubMed]
  • Poulter N, Khaw KT, Hopwood BE, Mugambi M, Peart WS, Rose G, Sever PS. Blood pressure and its correlates in an African tribe in urban and rural environments. J Epidemiol Community Health. 1984 Sep;38(3):181–185. [PMC free article] [PubMed]
  • Poulter NR, Lury JD, Thompson AV. Blood pressures higher in the home than in the clinic in rural Kenya. J Epidemiol Community Health. 1986 Jun;40(2):186–187. [PMC free article] [PubMed]
  • Rose G. Strategy of prevention: lessons from cardiovascular disease. Br Med J (Clin Res Ed) 1981 Jun 6;282(6279):1847–1851. [PMC free article] [PubMed]
  • Meneely GR, Battarbee HD. High sodium-low potassium environment and hypertension. Am J Cardiol. 1976 Nov 23;38(6):768–785. [PubMed]
  • Langford HG. Dietary potassium and hypertension: epidemiologic data. Ann Intern Med. 1983 May;98(5 Pt 2):770–772. [PubMed]
  • Khaw KT, Rose G. Population study of blood pressure and associated factors in St Lucia, West Indies. Int J Epidemiol. 1982 Dec;11(4):372–377. [PubMed]
  • Rikimaru T, Fujita Y, Okuda T, Kajiwara N, Miyatani S, Alpers MP, Koishi H. Responses of sodium balance, blood pressure, and other variables to sodium loading in Papua New Guinea highlanders. Am J Clin Nutr. 1988 Mar;47(3):502–508. [PubMed]
  • SCOTCH NA, GEIGER HJ. THE EPIDEMIOLOGY OF ESSENTIAL HYPERTENSION. A REVIEW WITH SPECIAL ATTENTION TO PSYCHOLOGIC AND SOCIOCULTURAL FACTORS. II. PSYCHOLOGIC AND SOCIO- CULTURAL FACTORS IN ETIOLOGY. J Chronic Dis. 1963 Nov;16:1183–1213. [PubMed]
  • London DR. Male infertility. Br Med J. 1972 Mar 4;1(5800):609–611. [PMC free article] [PubMed]
  • Koepke JP, DiBona GF. High sodium intake enhances renal nerve and antinatriuretic responses to stress in spontaneously hypertensive rats. Hypertension. 1985 May-Jun;7(3 Pt 1):357–363. [PubMed]
  • Light KC, Koepke JP, Obrist PA, Willis PW., 4th Psychological stress induces sodium and fluid retention in men at high risk for hypertension. Science. 1983 Apr 22;220(4595):429–431. [PubMed]
  • Staessen J, Bulpitt CJ, Thijs L, Fagard R, Joossens JV, Van Hoof R, Amery A. Sympathetic tone and relation between sodium intake and blood pressure in the general population. BMJ. 1989 Dec 16;299(6714):1502–1503. [PMC free article] [PubMed]
  • FOLKOW B, GRIMBY G, THULESIUS O. Adaptive structural changes of the vascular walls in hypertension and their relation to the control of the peripheral resistance. Acta Physiol Scand. 1958 Dec 15;44(3-4):255–272. [PubMed]
  • Lever AF. Slow pressor mechanisms in hypertension: a role for hypertrophy of resistance vessels? J Hypertens. 1986 Oct;4(5):515–524. [PubMed]
  • Klatsky AL, Friedman GD, Siegelaub AB, Gérard MJ. Alcohol consumption and blood pressure Kaiser-Permanente Multiphasic Health Examination data. N Engl J Med. 1977 May 26;296(21):1194–1200. [PubMed]
  • Carvalho JJ, Baruzzi RG, Howard PF, Poulter N, Alpers MP, Franco LJ, Marcopito LF, Spooner VJ, Dyer AR, Elliott P, et al. Blood pressure in four remote populations in the INTERSALT Study. Hypertension. 1989 Sep;14(3):238–246. [PubMed]

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