• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of bmjBMJ helping doctors make better decisionsSearch bmj.comLatest content
BMJ. Mar 3, 1990; 300(6724): 563–565.
PMCID: PMC1662343

Prevalence of vertebral compression fractures due to osteoporosis in ankylosing spondylitis.

Abstract

OBJECTIVE--To determine the prevalence of vertebral compression fractures due to osteoporosis in patients with ankylosing spondylitis. DESIGN--Prospective study of 111 consecutive patients; patients with vertebral compression fractures were entered into a case-control study. SETTING--Outpatient clinic at the centre for rheumatic diseases, Glasgow. PATIENTS--111 Consecutive patients with ankylosing spondylitis. Patients with compression fractures were matched for age and sex with two controls selected from the rest of the group. Patients with biconcave vertebral fractures were also studied. MAIN OUTCOME MEASURES--Assessments of spinal deformity and mobility and analysis of lateral radiographs of spines for presence of syndesmophytes. RESULTS--Fifteen patients with compression fractures and five with biconcave fractures were studied. Compared with the controls the patients with compression fractures had increased formation of syndesmophytes in the lumbar spine, whereas those with biconcave fractures had increased formation throughout the spine. Patients with compression fractures also had a greater degree of spinal deformity (distance from wall to tragus 24.5 cm v 12.7 cm in controls), less spinal mobility (20 v 45.6 degrees of flexion), and reduced chest expansion (2 cm v 3cm). CONCLUSION--Vertebral compression fractures due to osteoporosis are a common but frequently unrecognised complication of ankylosing spondylitis and may contribute to the pathogenesis of spinal deformity and back pain.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.0M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Spencer DG, Park WM, Dick HM, Papazoglou SN, Buchanan WW. Radiological manifestations in 200 patients with ankylosing spondylitis: correlation with clinical features and HLA B27. J Rheumatol. 1979 May-Jun;6(3):305–315. [PubMed]
  • POLLEY HF. The diagnosis and treatment of rheumatoid spondylitis. Med Clin North Am. 1955 Mar;12:509–528. [PubMed]
  • Hunter T, Dubo HI. Spinal fractures complicating ankylosing spondylitis. A long-term followup study. Arthritis Rheum. 1983 Jun;26(6):751–759. [PubMed]
  • WILKINSON M, BYWATERS EG. Clinical features and course of ankylosing spondylitis; as seen in a follow-up of 222 hospital referred cases. Ann Rheum Dis. 1958 Jun;17(2):209–228. [PMC free article] [PubMed]
  • Hurxthal LM. Measurement of anterior vertebral compressions and biconcave vertebrae. Am J Roentgenol Radium Ther Nucl Med. 1968 Jul;103(3):635–644. [PubMed]
  • BARNETT E, NORDIN BE. The radiological diagnosis of osteoporosis: a new approach. Clin Radiol. 1960 Jul;11:166–174. [PubMed]
  • Macrae IF, Haslock DI, Wright V. Grading of films for sacro-iliitis in population studies. Ann Rheum Dis. 1971 Jan;30(1):58–66. [PMC free article] [PubMed]
  • DILSEN N. ROMATIZMAL HASTALIKLARDA VERTEBRAL OSTEOPOROZ HAKKINDA. Turk Tip Cemiy Mecm. 1964 Jun;30:362–370. [PubMed]
  • Raisz LG. Local and systemic factors in the pathogenesis of osteoporosis. N Engl J Med. 1988 Mar 31;318(13):818–828. [PubMed]
  • Murby B, Fogelman I. Bone mineral measurements in clinical practice. Br J Hosp Med. 1987 May;37(5):453–458. [PubMed]
  • Reid DM, Nicoll JJ, Kennedy NS, Smith MA, Tothill P, Nuki G. Bone mass in ankylosing spondylitis. J Rheumatol. 1986 Oct;13(5):932–935. [PubMed]

Articles from BMJ : British Medical Journal are provided here courtesy of BMJ Group

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...