• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of bmjBMJ helping doctors make better decisionsSearch bmj.comLatest content
BMJ. Feb 3, 1990; 300(6720): 278–284.
PMCID: PMC1661907

Non-steroidal anti-inflammatory drugs and peptic ulcers.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.6M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Ehsanullah RS, Page MC, Tildesley G, Wood JR. Prevention of gastroduodenal damage induced by non-steroidal anti-inflammatory drugs: controlled trial of ranitidine. BMJ. 1988 Oct 22;297(6655):1017–1021. [PMC free article] [PubMed]
  • Graham DY, Agrawal NM, Roth SH. Prevention of NSAID-induced gastric ulcer with misoprostol: multicentre, double-blind, placebo-controlled trial. Lancet. 1988 Dec 3;2(8623):1277–1280. [PubMed]
  • Coggon D, Lambert P, Langman MJ. 20 years of hospital admissions for peptic ulcer in England and Wales. Lancet. 1981 Jun 13;1(8233):1302–1304. [PubMed]
  • Jolobe OM, Montgomery RD. Changing clinical pattern of gastric ulcer: are anti-inflammatory drugs involved? Digestion. 1984;29(3):164–170. [PubMed]
  • Walt R, Katschinski B, Logan R, Ashley J, Langman M. Rising frequency of ulcer perforation in elderly people in the United Kingdom. Lancet. 1986 Mar 1;1(8479):489–492. [PubMed]
  • Rossi AC, Hsu JP, Faich GA. Ulcerogenicity of piroxicam: an analysis of spontaneously reported data. Br Med J (Clin Res Ed) 1987 Jan 17;294(6565):147–150. [PMC free article] [PubMed]
  • Levy M. Aspirin use in patients with major upper gastrointestinal bleeding and peptic-ulcer disease. A report from the Boston Collaborative Drug Surveillance Program, Boston University Medical Center. N Engl J Med. 1974 May 23;290(21):1158–1162. [PubMed]
  • Piper DW, McIntosh JH, Ariotti DE, Fenton BH, MacLennan R. Analgesic ingestion and chronic peptic ulcer. Gastroenterology. 1981 Mar;80(3):427–432. [PubMed]
  • Clinch D, Banerjee AK, Ostick G, Levy DW. Non-steroidal anti-inflammatory drugs and gastrointestinal adverse effects. J R Coll Physicians Lond. 1983 Oct;17(4):228–230. [PubMed]
  • McIntosh JH, Byth K, Piper DW. Environmental factors in aetiology of chronic gastric ulcer: a case control study of exposure variables before the first symptoms. Gut. 1985 Aug;26(8):789–798. [PMC free article] [PubMed]
  • Duggan JM, Dobson AJ, Johnson H, Fahey P. Peptic ulcer and non-steroidal anti-inflammatory agents. Gut. 1986 Aug;27(8):929–933. [PMC free article] [PubMed]
  • Coggon D, Langman MJ, Spiegelhalter D. Aspirin, paracetamol, and haematemesis and melaena. Gut. 1982 Apr;23(4):340–344. [PMC free article] [PubMed]
  • Somerville K, Faulkner G, Langman M. Non-steroidal anti-inflammatory drugs and bleeding peptic ulcer. Lancet. 1986 Mar 1;1(8479):462–464. [PubMed]
  • Armstrong CP, Blower AL. Non-steroidal anti-inflammatory drugs and life threatening complications of peptic ulceration. Gut. 1987 May;28(5):527–532. [PMC free article] [PubMed]
  • Carson JL, Strom BL, Soper KA, West SL, Morse ML. The association of nonsteroidal anti-inflammatory drugs with upper gastrointestinal tract bleeding. Arch Intern Med. 1987 Jan;147(1):85–88. [PubMed]
  • Beard K, Walker AM, Perera DR, Jick H. Nonsteroidal anti-inflammatory drugs and hospitalization for gastroesophageal bleeding in the elderly. Arch Intern Med. 1987 Sep;147(9):1621–1623. [PubMed]
  • Levy M, Miller DR, Kaufman DW, Siskind V, Schwingl P, Rosenberg L, Strom B, Shapiro S. Major upper gastrointestinal tract bleeding. Relation to the use of aspirin and other nonnarcotic analgesics. Arch Intern Med. 1988 Feb;148(2):281–285. [PubMed]
  • Faulkner G, Prichard P, Somerville K, Langman MJ. Aspirin and bleeding peptic ulcers in the elderly. BMJ. 1988 Nov 19;297(6659):1311–1313. [PMC free article] [PubMed]
  • Griffin MR, Ray WA, Schaffner W. Nonsteroidal anti-inflammatory drug use and death from peptic ulcer in elderly persons. Ann Intern Med. 1988 Sep 1;109(5):359–363. [PubMed]
  • Thompson MR. Indomethacin and perforated duodenal ulcer. Br Med J. 1980 Feb 16;280(6212):448–448. [PMC free article] [PubMed]
  • Collier DS, Pain JA. Non-steroidal anti-inflammatory drugs and peptic ulcer perforation. Gut. 1985 Apr;26(4):359–363. [PMC free article] [PubMed]
  • Jick SS, Perera DR, Walker AM, Jick H. Non-steroidal anti-inflammatory drugs and hospital admission for perforated peptic ulcer. Lancet. 1987 Aug 15;2(8555):380–382. [PubMed]
  • Sun DC, Roth SH, Mitchell CS, Englund DW. Upper gastrointestinal disease in rheumatoid arthritis. Am J Dig Dis. 1974 May;19(5):405–410. [PubMed]
  • Silvoso GR, Ivey KJ, Butt JH, Lockard OO, Holt SD, Sisk C, Baskin WN, Mackercher PA, Hewett J. Incidence of gastric lesions in patients with rheumatic disease on chronic aspirin therapy. Ann Intern Med. 1979 Oct;91(4):517–520. [PubMed]
  • Collins AJ, Du Toit JA. Upper gastrointestinal findings and faecal occult blood in patients with rheumatic diseases taking nonsteroidal anti-inflammatory drugs. Br J Rheumatol. 1987 Aug;26(4):295–298. [PubMed]
  • Larkai EN, Smith JL, Lidsky MD, Graham DY. Gastroduodenal mucosa and dyspeptic symptoms in arthritic patients during chronic nonsteroidal anti-inflammatory drug use. Am J Gastroenterol. 1987 Nov;82(11):1153–1158. [PubMed]
  • Farah D, Sturrock RD, Russell RI. Peptic ulcer in rheumatoid arthritis. Ann Rheum Dis. 1988 Jun;47(6):478–480. [PMC free article] [PubMed]
  • Caruso I, Bianchi Porro G. Gastroscopic evaluation of anti-inflammatory agents. Br Med J. 1980 Jan 12;280(6207):75–78. [PMC free article] [PubMed]
  • MANTEL N, HAENSZEL W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959 Apr;22(4):719–748. [PubMed]
  • Miettinen O. Estimability and estimation in case-referent studies. Am J Epidemiol. 1976 Feb;103(2):226–235. [PubMed]
  • McIntosh JH, Fung CS, Berry G, Piper DW. Smoking, nonsteroidal anti-inflammatory drugs, and acetaminophen in gastric ulcer. A study of associations and of the effects of previous diagnosis on exposure patterns. Am J Epidemiol. 1988 Oct;128(4):761–770. [PubMed]
  • Whittle BJ, Kauffman GL, Jr, Moncada S. Hemostatic mechanisms, independent of platelet aggregation, arrest gastric mucosal bleeding. Proc Natl Acad Sci U S A. 1986 Aug;83(15):5683–5687. [PMC free article] [PubMed]
  • Benowitz NL. Clinical pharmacology of nicotine. Annu Rev Med. 1986;37:21–32. [PubMed]
  • Lassila R, Seyberth HW, Haapanen A, Schweer H, Koskenvuo M, Laustiola KE. Vasoactive and atherogenic effects of cigarette smoking: a study of monozygotic twins discordant for smoking. BMJ. 1988 Oct 15;297(6654):955–957. [PMC free article] [PubMed]
  • Ihamäki T, Varis K, Siurala M. Morphological, functional and immunological state of the gastric mucosa in gastric carcinoma families. Comparison with a computer-matched family sample. Scand J Gastroenterol. 1979;14(7):801–812. [PubMed]
  • Kawai K. Screening for gastric cancer in Japan. Clin Gastroenterol. 1978 Sep;7(3):605–622. [PubMed]
  • Araki S, Goto Y. Peptic ulcer in male factory workers: a survey of prevalence, incidence, and aetiological factors. J Epidemiol Community Health. 1985 Mar;39(1):82–85. [PMC free article] [PubMed]
  • SEGI M, FUJISAKU S, KURIHARA M. Mortality for gastric and duodenal ulcer in countries and its geographical correlation to mortality for gastric and intestinal cancer. Schweiz Z Pathol Bakteriol. 1959;22:777–784. [PubMed]
  • Jorde R, Burhol PG. Asymptomatic peptic ulcer disease. Scand J Gastroenterol. 1987 Mar;22(2):129–134. [PubMed]
  • Skander MP, Ryan FP. Non-steroidal anti-inflammatory drugs and pain free peptic ulceration in the elderly. BMJ. 1988 Oct 1;297(6652):833–834. [PMC free article] [PubMed]
  • Graham DY, Smith JL, Spjut HJ, Torres E. Gastric adaptation. Studies in humans during continuous aspirin administration. Gastroenterology. 1988 Aug;95(2):327–333. [PubMed]
  • Roth SH, Bennett RE, Mitchell CS, Hartman RJ. Cimetidine therapy in nonsteroidal anti-inflammatory drug gastropathy. Double-blind long-term evaluation. Arch Intern Med. 1987 Oct;147(10):1798–1801. [PubMed]
  • Roth SH, Bennett RE. Nonsteroidal anti-inflammatory drug gastropathy. Recognition and response. Arch Intern Med. 1987 Dec;147(12):2093–2100. [PubMed]

Articles from BMJ : British Medical Journal are provided here courtesy of BMJ Group


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


  • PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...