Cardiovascular Disease: Folic acid, homocysteine, and cardiovascular disease: judging causality in the face of inconclusive trial evidence

Journal List > BMJ > v.333(7578); Nov 25, 2006

BMJ. 2006 November 25; 333(7578): 1114–1117.

doi: 10.1136/bmj.39000.486701.68.

PMCID: PMC1661741

Copyright © BMJ Publishing Group Ltd 2006

Cardiovascular Disease

Folic acid, homocysteine, and cardiovascular disease: judging causality in the face of inconclusive trial evidence

David S Wald, senior lecturer and consultant cardiologist, Nicholas J Wald, professor of epidemiology and preventive medicine, Joan K Morris, reader in medical statistics, and Malcolm Law, professor of environmental and preventive medicine

¹Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and The London, Queen Mary's School of Medicine and Dentistry, London EC1M 6BQ

Correspondence to: D S Wald Email: d.s.wald/at/qmul.ac.uk

Accepted September 21, 2006.

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Increasing intake of folic acid would be a relatively cheap and simple way of reducing heart disease, if it works. Can we draw a definitive conclusion from the current evidence?

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