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Am J Public Health. 1982 January; 72(1): 65–68.
PMCID: PMC1649756

The decreasing incidence of endometrial cancer: public health implications.


The incidence of endometrial cancer in the San Francisco area between 1969 and 1979 is compared to trends in estrogen sales and prescriptions. Both estrogen use and endometrial cancer incidence increased steadily until 1975 and then decreased significantly. The data support the previously documented association between endometrial cancer and estrogen use, but suggest that short-term usage may carry only slightly increased risk which can be eliminating entirely upon termination of therapy.

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Selected References

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  • Austin DF, Roe KM. Increase in cancer of the corpus uteri in the San Francisco-Oakland standard metropolitan statistical area, 1960--75. J Natl Cancer Inst. 1979 Jan;62(1):13–16. [PubMed]
  • Weiss NS, Szekely DR, Austin DF. Increasing incidence of endometrial cancer in the United States. N Engl J Med. 1976 Jun 3;294(23):1259–1262. [PubMed]
  • Smith DC, Prentice R, Thompson DJ, Herrmann WL. Association of exogenous estrogen and endometrial carcinoma. N Engl J Med. 1975 Dec 4;293(23):1164–1167. [PubMed]
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  • Jelovsek FR, Hammond CB, Woodard BH, Draffin R, Lee KL, Creasman WT, Parker RT. Risk of exogenous estrogen therapy and endometrial cancer. Am J Obstet Gynecol. 1980 May 1;137(1):85–91. [PubMed]
  • Hulka BS, Fowler WC, Jr, Kaufman DG, Grimson RC, Greenberg BG, Hogue CJ, Berger GS, Pulliam CC. Estrogen and endometrial cancer: cases and two control groups from North Carolina. Am J Obstet Gynecol. 1980 May 1;137(1):92–101. [PubMed]
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