• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of aacPermissionsJournals.ASM.orgJournalAAC ArticleJournal InfoAuthorsReviewers
Antimicrob Agents Chemother. Nov 1997; 41(11): 2321–2325.
PMCID: PMC164122

Why are antibiotic resistance genes so resistant to elimination?

Full Text

The Full Text of this article is available as a PDF (217K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Amábile-Cuevas CF, Chicurel ME. A possible role for plasmids in mediating the cell-cell proximity required for gene flux. J Theor Biol. 1996 Aug 7;181(3):237–243. [PubMed]
  • Andersen SR, Sandaa RA. Distribution of tetracycline resistance determinants among gram-negative bacteria isolated from polluted and unpolluted marine sediments. Appl Environ Microbiol. 1994 Mar;60(3):908–912. [PMC free article] [PubMed]
  • Ankenbauer RG. Reassessing forty years of genetic doctrine: retrotransfer and conjugation. Genetics. 1997 Mar;145(3):543–549. [PMC free article] [PubMed]
  • Boe L, Marinus MG. Role of plasmid multimers in mutation to tetracycline resistance. Mol Microbiol. 1991 Oct;5(10):2541–2545. [PubMed]
  • Calva JJ, Sifuentes-Osornio J, Cerón C. Antimicrobial resistance in fecal flora: longitudinal community-based surveillance of children from urban Mexico. Antimicrob Agents Chemother. 1996 Jul;40(7):1699–1702. [PMC free article] [PubMed]
  • Courvalin P. Transfer of antibiotic resistance genes between gram-positive and gram-negative bacteria. Antimicrob Agents Chemother. 1994 Jul;38(7):1447–1451. [PMC free article] [PubMed]
  • Doucet-Populaire F, Trieu-Cuot P, Andremont A, Courvalin P. Conjugal transfer of plasmid DNA from Enterococcus faecalis to Escherichia coli in digestive tracts of gnotobiotic mice. Antimicrob Agents Chemother. 1992 Feb;36(2):502–504. [PMC free article] [PubMed]
  • Gerding DN, Larson TA, Hughes RA, Weiler M, Shanholtzer C, Peterson LR. Aminoglycoside resistance and aminoglycoside usage: ten years of experience in one hospital. Antimicrob Agents Chemother. 1991 Jul;35(7):1284–1290. [PMC free article] [PubMed]
  • Götz A, Pukall R, Smit E, Tietze E, Prager R, Tschäpe H, van Elsas JD, Smalla K. Detection and characterization of broad-host-range plasmids in environmental bacteria by PCR. Appl Environ Microbiol. 1996 Jul;62(7):2621–2628. [PMC free article] [PubMed]
  • Hall RM, Collis CM. Mobile gene cassettes and integrons: capture and spread of genes by site-specific recombination. Mol Microbiol. 1995 Feb;15(4):593–600. [PubMed]
  • Lenski RE, Simpson SC, Nguyen TT. Genetic analysis of a plasmid-encoded, host genotype-specific enhancement of bacterial fitness. J Bacteriol. 1994 Jun;176(11):3140–3147. [PMC free article] [PubMed]
  • Nowak R. Hungary sees an improvement in penicillin resistance. Science. 1994 Apr 15;264(5157):364–364. [PubMed]
  • Roberts MC, Chung WO, Roe DE. Characterization of tetracycline and erythromycin resistance determinants in Treponema denticola. Antimicrob Agents Chemother. 1996 Jul;40(7):1690–1694. [PMC free article] [PubMed]
  • Salyers AA, Shoemaker NB, Stevens AM, Li LY. Conjugative transposons: an unusual and diverse set of integrated gene transfer elements. Microbiol Rev. 1995 Dec;59(4):579–590. [PMC free article] [PubMed]
  • Salyers AA, Shoemaker NB. Resistance gene transfer in anaerobes: new insights, new problems. Clin Infect Dis. 1996 Dec;23 (Suppl 1):S36–S43. [PubMed]
  • Sia EA, Kuehner DM, Figurski DH. Mechanism of retrotransfer in conjugation: prior transfer of the conjugative plasmid is required. J Bacteriol. 1996 Mar;178(5):1457–1464. [PMC free article] [PubMed]
  • Smith CJ, Parker AC. Identification of a circular intermediate in the transfer and transposition of Tn4555, a mobilizable transposon from Bacteroides spp. J Bacteriol. 1993 May;175(9):2682–2691. [PMC free article] [PubMed]
  • Summers AO, Wireman J, Vimy MJ, Lorscheider FL, Marshall B, Levy SB, Bennett S, Billard L. Mercury released from dental "silver" fillings provokes an increase in mercury- and antibiotic-resistant bacteria in oral and intestinal floras of primates. Antimicrob Agents Chemother. 1993 Apr;37(4):825–834. [PMC free article] [PubMed]
  • Top E, De Smet I, Verstraete W, Dijkmans R, Mergeay M. Exogenous isolation of mobilizing plasmids from polluted soils and sludges. Appl Environ Microbiol. 1994 Mar;60(3):831–839. [PMC free article] [PubMed]
  • van der Bij AJ, de Weger LA, Tucker WT, Lugtenberg B. Plasmid Stability in Pseudomonas fluorescens in the Rhizosphere. Appl Environ Microbiol. 1996 Mar;62(3):1076–1080. [PMC free article] [PubMed]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


  • Cited in Books
    Cited in Books
    PubMed Central articles cited in books
  • PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...