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HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-γc-/- (RAG-hu) mouse model
Bradford K Berges, William H Wheat, Brent E Palmer, Elizabeth Connick, Ramesh Akkina
Retrovirology. 2006; 3: 76. Published online 2006 November 1. doi: 10.1186/1742-4690-3-76
PMCID:
PMC1635423
Abstract Full Text PDF–1.3M
 Is Cited by the Following 29 Articles in this Archive:
The utility of the new generation of humanized mice to study HIV-1 infection: transmission, prevention, pathogenesis, and treatment
Bradford K Berges, Mark R Rowan
Retrovirology. 2011; 8: 65. Published online 2011 August 11. doi: 10.1186/1742-4690-8-65
PMCID:
PMC3170263
Abstract Full Text PDF–504K
Humanized Rag1−/−γc−/− Mice Support Multilineage Hematopoiesis and Are Susceptible to HIV-1 Infection via Systemic and Vaginal Routes
Ramesh Akkina, Bradford K. Berges, Brent E. Palmer, Leila Remling, C. Preston Neff, Jes Kuruvilla, Elizabeth Connick, Joy Folkvord, Kathy Gagliardi, Afework Kassu, Sarah R. Akkina
PLoS One. 2011; 6(6): e20169. Published online 2011 June 14. doi: 10.1371/journal.pone.0020169
PMCID:
PMC3114781
Abstract Full Text PDF–2.9M
A Topical Microbicide Gel Formulation of CCR5 Antagonist Maraviroc Prevents HIV-1 Vaginal Transmission in Humanized RAG-hu Mice
C. Preston Neff, Theresa Kurisu, Thomas Ndolo, Kami Fox, Ramesh Akkina
PLoS One. 2011; 6(6): e20209. Published online 2011 June 1. doi: 10.1371/journal.pone.0020209
PMCID:
PMC3105981
Abstract Full Text PDF–201K
An Aptamer-siRNA Chimera Suppresses HIV-1 Viral Loads and Protects from Helper CD4+ T Cell Decline in Humanized Mice
Charles Preston Neff, Jiehua Zhou, Leila Remling, Jes Kuruvilla, Jane Zhang, Haitang Li, David D. Smith, Piotr Swiderski, John J. Rossi, Ramesh Akkina
Sci Transl Med. Author manuscript; available in PMC 2011 July 18.
Published in final edited form as: Sci Transl Med. 2011 January 19; 3(66): 66ra6. doi: 10.1126/scitranslmed.3001581
PMCID:
PMC3138523
Abstract Full Text PDF–1.2M Supplementary Material
Oral Pre-Exposure Prophylaxis by Anti-Retrovirals Raltegravir and Maraviroc Protects against HIV-1 Vaginal Transmission in a Humanized Mouse Model
C. Preston Neff, Thomas Ndolo, Apurva Tandon, Yuichiro Habu, Ramesh Akkina
PLoS One. 2010; 5(12): e15257. Published online 2010 December 21. doi: 10.1371/journal.pone.0015257
PMCID:
PMC3006206
Abstract Full Text PDF–289K
Zinc finger nuclease-mediated CCR5 knockout hematopoietic stem cell transplantation controls HIV-1 in vivo
Nathalia Holt, Jianbin Wang, Kenneth Kim, Geoffrey Friedman, Xingchao Wang, Vanessa Taupin, Gay M. Crooks, Donald B. Kohn, Philip D. Gregory, Michael C. Holmes, Paula M. Cannon
Nat Biotechnol. Author manuscript; available in PMC 2011 April 21.
Published in final edited form as: Nat Biotechnol. 2010 August; 28(8): 839–847. Published online 2010 July 2. doi: 10.1038/nbt.1663
PMCID:
PMC3080757
Abstract Full Text PDF–2.1M Supplementary Material
Highly Active Antiretroviral Therapy Potently Suppresses HIV Infection in Humanized Rag2-/-γc-/- Mice
Kaori Sango, Aviva Joseph, Mahesh Patel, Kristin Osiecki, Monica Dutta, Harris Goldstein
AIDS Res Hum Retroviruses. 2010 July; 26(7): 735–746. doi: 10.1089/aid.2009.0136
PMCID:
PMC2932557
Abstract Full Text PDF–459K
Inadequate Clearance of Translocated Bacterial Products in HIV-Infected Humanized Mice
Ursula Hofer, Erika Schlaepfer, Stefan Baenziger, Marc Nischang, Stephan Regenass, Reto Schwendener, Werner Kempf, David Nadal, Roberto F. Speck
PLoS Pathog. 2010 April; 6(4): e1000867. Published online 2010 April 29. doi: 10.1371/journal.ppat.1000867
PMCID:
PMC2861703
Abstract Full Text PDF–545K Supplementary Material
Th1 and Th17 Immunocompetence in Humanized NOD/SCID/γC-KO mice
Deepika Rajesh, Ying Zhou, Ewa Jankowska-Gan, Drew Allan Ronneburg, Melanie M Dart, Jose Torrealba, William J Burlingham
Hum Immunol. Author manuscript; available in PMC 2011 June 1.
Published in final edited form as: Hum Immunol. 2010 June; 71(6): 551–559. Published online 2010 March 26. doi: 10.1016/j.humimm.2010.02.019
PMCID:
PMC2875879
Abstract Full Text PDF–5.2M
Evolution of the HIV-1 env Gene in the Rag2−/− γC−/− Humanized Mouse Model
William L. Ince, Liguo Zhang, Qi Jiang, Kathryn Arrildt, Lishan Su, Ronald Swanstrom
J Virol. 2010 March; 84(6): 2740–2752. Published online 2009 December 30. doi: 10.1128/JVI.02180-09
PMCID:
PMC2826074
Abstract Full Text PDF–560K
RNAi-mediated CCR5 Silencing by LFA-1-targeted Nanoparticles Prevents HIV Infection in BLT Mice
Sang-Soo Kim, Dan Peer, Priti Kumar, Sandesh Subramanya, Huaquan Wu, Deshratan Asthana, Katsuyoshi Habiro, Yong-Guang Yang, N Manjunath, Motomu Shimaoka, Premlata Shankar
Mol Ther. 2010 February; 18(2): 370–376. Published online 2009 December 8. doi: 10.1038/mt.2009.271
PMCID:
PMC2839291
Abstract Full Text PDF–283K
Protection of Stem Cell-Derived Lymphocytes in a Primate AIDS Gene Therapy Model after In Vivo Selection
Grant D. Trobridge, Robert A. Wu, Brian C. Beard, Sum Ying Chiu, Nina M. Muñoz, Dorothee von Laer, John J. Rossi, Hans-Peter Kiem
PLoS One. 2009; 4(11): e7693. Published online 2009 November 2. doi: 10.1371/journal.pone.0007693
PMCID:
PMC2765621
Abstract Full Text PDF–331K
Melanoma-initiating cells: a compass needed
Yosef Refaeli, Anindita Bhoumik, Dennis R Roop, Ze'ev A Ronai
EMBO Rep. 2009 September; 10(9): 965–972. Published online 2009 August 14. doi: 10.1038/embor.2009.184
PMCID:
PMC2750051
Abstract Full Text PDF–387K
The utilization of humanized mouse models for the study of human retroviral infections
Rachel Van Duyne, Caitlin Pedati, Irene Guendel, Lawrence Carpio, Kylene Kehn-Hall, Mohammed Saifuddin, Fatah Kashanchi
Retrovirology. 2009; 6: 76. Published online 2009 August 12. doi: 10.1186/1742-4690-6-76
PMCID:
PMC2743631
Abstract Full Text PDF–1.4M
Mucosal Innate and Adaptive Immune Responses against Herpes Simplex Virus Type 2 in a Humanized Mouse Model
Amanda Kwant-Mitchell, Ali A. Ashkar, Kenneth L. Rosenthal
J Virol. 2009 October; 83(20): 10664–10676. Published online 2009 August 5. doi: 10.1128/JVI.02584-08
PMCID:
PMC2753120
Abstract Full Text PDF–2.5M
Suppression of Human Immunodeficiency Virus Type 1 (HIV-1) Viremia with Reverse Transcriptase and Integrase Inhibitors, CD4+ T-Cell Recovery, and Viral Rebound upon Interruption of Therapy in a New Model for HIV Treatment in the Humanized Rag2−/−γc−/− Mouse
Shailesh K. Choudhary, Naser L. Rezk, William L. Ince, Manzoor Cheema, Liguo Zhang, Lishan Su, Ronald Swanstrom, Angela D. M. Kashuba, David M. Margolis
J Virol. 2009 August; 83(16): 8254–8258. Published online 2009 June 3. doi: 10.1128/JVI.00580-09
PMCID:
PMC2715775
Abstract Full Text PDF–1.8M Supplementary Material
Induction of Robust Cellular and Humoral Virus-Specific Adaptive Immune Responses in Human Immunodeficiency Virus-Infected Humanized BLT Mice
Diana M. Brainard, Edward Seung, Nicole Frahm, Annaiah Cariappa, Charles C. Bailey, William K. Hart, Hae-Sook Shin, Sarah F. Brooks, Heather L. Knight, Quentin Eichbaum, Yong-Guang Yang, Megan Sykes, Bruce D. Walker, Gordon J. Freeman, Shiv Pillai, Susan V. Westmoreland, Christian Brander, Andrew D. Luster, Andrew M. Tager
J Virol. 2009 July; 83(14): 7305–7321. Published online 2009 May 6. doi: 10.1128/JVI.02207-08
PMCID:
PMC2704767
Abstract Full Text PDF–4.4M
H-index, mentoring-index, highly-cited and highly-accessed: how to evaluate scientists?
Kuan-Teh Jeang
Retrovirology. 2008; 5: 106. Published online 2008 November 25. doi: 10.1186/1742-4690-5-106
PMCID:
PMC2607307
Abstract Full Text PDF–203K
RAG2−/−γc−/− Mice Transplanted with CD34+ Cells from Human Cord Blood Show Low Levels of Intestinal Engraftment and Are Resistant to Rectal Transmission of Human Immunodeficiency Virus
Ursula Hofer, Stefan Baenziger, Mathias Heikenwalder, Erika Schlaepfer, Nadine Gehre, Stephan Regenass, Thomas Brunner, Roberto F. Speck
J Virol. 2008 December; 82(24): 12145–12153. Published online 2008 October 8. doi: 10.1128/JVI.01105-08
PMCID:
PMC2593344
Abstract Full Text PDF–1.3M
FoxP3+CD4+ regulatory T cells play an important role in acute HIV-1 infection in humanized Rag2−/−γC−/− mice in vivo
Qi Jiang, Liguo Zhang, Rui Wang, Jerry Jeffrey, Michael L. Washburn, Dedeke Brouwer, Selena Barbour, Grigoriy I. Kovalev, Derya Unutmaz, Lishan Su
Blood. 2008 October 1; 112(7): 2858–2868. Prepublished online 2008 June 10. doi: 10.1182/blood-2008-03-145946
PMCID:
PMC2556621
Abstract Full Text Supplementary Material
T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice
Priti Kumar, Hong-Seok Ban, Sang-Soo Kim, Haoquan Wu, Todd Pearson, Dale. L. Greiner, Amale Laouar, Jiahong Yao, Viraga Haridas, Katsuyoshi Habiro, Yong-Guang Yang, Ji-Hoon Jeong, Kuen-Yong Lee, Yong-Hee Kim, Sung Wan Kim, Matthias Peipp, Georg H. Fey, N Manjunath, Leonard D. Shultz, Sang-Kyung Lee, Premlata Shankar
Cell. Author manuscript; available in PMC 2010 September 21.
Published in final edited form as: Cell. 2008 August 22; 134(4): 577–586. Published online 2008 August 7. doi: 10.1016/j.cell.2008.06.034
PMCID:
PMC2943428
Abstract Full Text PDF–1.0M Supplementary Material
Establishing humanized mice using stem cells: maximizing the potential
D Bernard, M Peakman, A C Hayday
Clin Exp Immunol. 2008 June; 152(3): 406–414. doi: 10.1111/j.1365-2249.2008.03659.x
PMCID:
PMC2453213
Abstract Full Text PDF–449K
Summary of presentations at the NIH/NIAID New Humanized Rodent Models 2007 Workshop
Harris Goldstein
AIDS Res Ther. 2008; 5: 3. Published online 2008 January 31. doi: 10.1186/1742-6405-5-3
PMCID:
PMC2276217
Abstract Full Text PDF–274K
Vaginal and rectal mucosal transmission of R5 and X4 tropic HIV-1 in humanized Rag2−/−γc−/− (RAG-hu) mice
Bradford K. Berges, Sarah R. Akkina, Joy M. Folkvord, Elizabeth Connick, Ramesh Akkina
Virology. Author manuscript; available in PMC 2011 May 11.
Published in final edited form as: Virology. 2008 April 10; 373(2): 342–351. Published online 2008 January 18. doi: 10.1016/j.virol.2007.11.020
PMCID:
PMC3092740
Abstract Full Text PDF–1.1M
Humanized NOD/SCID/IL2Rγnull Mice Transplanted with Hematopoietic Stem Cells under Nonmyeloablative Conditions Show Prolonged Life Spans and Allow Detailed Analysis of Human Immunodeficiency Virus Type 1 Pathogenesis
Satoru Watanabe, Shinrai Ohta, Misako Yajima, Kazuo Terashima, Mamoru Ito, Hideo Mugishima, Shigeyoshi Fujiwara, Kazufumi Shimizu, Mitsuo Honda, Norio Shimizu, Naoki Yamamoto
J Virol. 2007 December; 81(23): 13259–13264. Published online 2007 September 19. doi: 10.1128/JVI.01353-07
PMCID:
PMC2169100
Abstract Full Text PDF–420K
Validation of the SCID-hu Thy/Liv Mouse Model with Four Classes of Licensed Antiretrovirals
Cheryl A. Stoddart, Cheryl A. Bales, Jennifer C. Bare, George Chkhenkeli, Sofiya A. Galkina, April N. Kinkade, Mary E. Moreno, José M. Rivera, Rollie E. Ronquillo, Barbara Sloan, Paul L. Black
PLoS ONE. 2007; 2(8): e655. Published online 2007 August 1. doi: 10.1371/journal.pone.0000655
PMCID:
PMC1925140
Abstract Full Text PDF–767K
Multiple Restrictions of Human Immunodeficiency Virus Type 1 in Feline Cells
Carsten Münk, Jörg Zielonka, Hannelore Constabel, Björn-Philipp Kloke, Benjamin Rengstl, Marion Battenberg, Francesca Bonci, Mauro Pistello, Martin Löchelt, Klaus Cichutek
J Virol. 2007 July; 81(13): 7048–7060. Published online 2007 April 25. doi: 10.1128/JVI.02714-06
PMCID:
PMC1933292
Abstract Full Text PDF–538K
Use of a Novel Chimeric Mouse Model with a Functionally Active Human Immune System To Study Human Immunodeficiency Virus Type 1 Infection
Dong Sung An, Betty Poon, Raphael Ho Tsong Fang, Kees Weijer, Bianca Blom, Hergen Spits, Irvin S. Y. Chen, Christel H. Uittenbogaart
Clin Vaccine Immunol. 2007 April; 14(4): 391–396. Published online 2007 February 21. doi: 10.1128/CVI.00403-06
PMCID:
PMC1865603
Abstract Full Text PDF–138K
Novel In Vivo Model for the Study of Human Immunodeficiency Virus Type 1 Transcription Inhibitors: Evaluation of New 6-Desfluoroquinolone Derivatives
Miguel Stevens, Michela Pollicita, Christophe Pannecouque, Erik Verbeken, Oriana Tabarrini, Violetta Cecchetti, Stefano Aquaro, Carlo Federico Perno, Arnaldo Fravolini, Erik De Clercq, Dominique Schols, Jan Balzarini
Antimicrob Agents Chemother. 2007 April; 51(4): 1407–1413. Published online 2007 January 22. doi: 10.1128/AAC.01251-06
PMCID:
PMC1855509
Abstract Full Text PDF–517K
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