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Antimicrob Agents Chemother. Nov 2006; 50(11): 3953–3955.
Published online Sep 5, 2006. doi:  10.1128/AAC.00915-06
PMCID: PMC1635235

Prevalence in the United States of aac(6)-Ib-cr Encoding a Ciprofloxacin-Modifying Enzyme


Among 313 Enterobacteriaceae from the United States with a ciprofloxacin MIC of ≥0.25 μg/ml and reduced susceptibility to ceftazidime, aac(6)-Ib was present in 50.5% of isolates, and of these, 28% carried the cr variant responsible for low-level ciprofloxacin resistance. aac(6)-Ib-cr was geographically widespread, stable over time, most common in Escherichia coli, equally prevalent in ciprofloxacin-susceptible and -resistant strains, and not associated with qnr genes.

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